Comprehensive analysis of common polymers using hyphenated TGA-FTIR-GC/MS and Raman spectroscopy towards a database for micro- and nanoplastics identification, characterization, and quantitation

Jung, Sung-Yoon; Raghavendra, Achyut J.; Patri, Anil K.

doi:10.1016/j.impact.2023.100467

Cited by 8 publications

(4 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notwithstanding these correction strategies, only the relative levels of the target plastic are obtained, not the absolute values. Confirmation by more specific (and expensive) methodologies such as thermogravimetric Fourier transformation infrared spectroscopy or pyrolysis GC-MS spectrometry would be required (Jung et al, 2023). Based on the following: (signal of other plastics /signal target plastic) x 100 for the same quantity of plastic (50 ug/mL).…”

Section: Resultsmentioning

confidence: 99%

Plastic analysis with a plasmonic nano-gold sensor coated with plastic binding peptides.

Gagné,

Gauthier,

André

2024

Preprint

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Plastic analysis with a plasmonic nano-gold sensor coated with plastic binding peptides.

Gagné,

Gauthier,

André

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Notwithstanding these correction strategies, only the relative levels of the target plastic could be obtained, not the absolute values. Confirmation by additional methodologies such as thermogravimetric Fourier transformation infrared spectroscopy (TG-IR) or pyrolysis gas chromatography-mass spectrometry (Py-GC-MS) would be required [25]. The peptides could be used together to coat the nAu sensor and provide a 'total' measurement of plastics (PS, PP, PE, and PET).…”

Section: Resultsmentioning

confidence: 99%

Plastic Analysis with a Plasmonic Nano-Gold Sensor Coated with Plastic-Binding Peptides

Gagné,

Gauthier,

André

2024

JoX

View full text Add to dashboard Cite

Contamination with plastics of small dimensions (<1 µm) represents a health concern for many terrestrial and aquatic organisms. This study examined the use of plastic-binding peptides as a coating probe to detect various types of plastic using a plasmon nano-gold sensor. Plastic-binding peptides were selected for polyethylene (PE), polyethylene terephthalate (PET), polypropylene (PP), and polystyrene (PS) based on the reported literature. Using nAu with each of these peptides to test the target plastics revealed high signal, at 525/630 nm, suggesting that the target plastic limited HCl-induced nAu aggregation. Testing with other plastics revealed some lack of specificity but the signal was always lower than that of the target plastic. This suggests that these peptides, although reacting mainly with their target plastic, show partial reactivity with the other target plastics. By using a multiple regression model, the relative levels of a given plastic could be corrected by the presence of other plastics. This approach was tested in freshwater mussels caged for 3 months at sites suspected to release plastic materials: in rainfall overflow discharges, downstream a largely populated city, and in a municipal effluent dispersion plume. The data revealed that the digestive glands of the mussels contained higher levels of PP, PE, and PET plastic particles at the rainfall overflow and downstream city sites compared to the treated municipal effluent site. This corroborated earlier findings that wastewater treatment could remove nanoparticles, at least in part. A quick and inexpensive screening test for plastic nanoparticles in biological samples with plasmonic nAu-peptides is proposed.

show abstract

“…Recognizing the need for sound analytical methods to detect and characterize MPs and NPs in human food, the FDA has performed method development in its own laboratories with the focus on characterization. For example, FDA conducted research to aid in the identification and quantification of the most common polymers documented in the environment . This research utilized hyphenated thermogravimetric analysis–Fourier-transformed infrared spectroscopy–gas chromatography–mass spectrometry (TGA-FTIR-GC-MS) and corresponding Raman spectral data for the 35 most common polymers to develop a baseline reference database for the identification and quantitation of MPs and NPs.…”

Section: Deploying Mp and Np Analysis Methods To Support Regulatory S...mentioning

confidence: 99%

“…For example, FDA conducted research to aid in the identification and quantification of the most common polymers documented in the environment. 207 This research utilized hyphenated thermogravimetric analysis−Fourier-transformed infrared spectroscopy−gas chromatography−mass spectrometry (TGA-FTIR-GC-MS) and corresponding Raman spectral data for the 35 most common polymers to develop a baseline reference database for the identification and quantitation of MPs and NPs. Nevertheless, because novel techniques, instrumentation, and method development are often initiated outside the agency as fundamental research, FDA's regulatory scientists are attuned to advances in basic measurement science that originate from academia; industry; and other federal, state, and local agencies.…”

Section: Support Regulatory Sciencementioning

confidence: 99%

Regulatory Science Perspective on the Analysis of Microplastics and Nanoplastics in Human Food

Duncan,

Khan,

Patri

et al. 2024

Anal. Chem.

Self Cite

View full text Add to dashboard Cite

Microplastics are increasingly reported, not only in the environment but also in a wide range of food commodities. While studies on microplastics in food abound, the current state of science is limited in its application to regulatory risk assessment by a continued lack of standardized definitions, reference materials, sample collection and preparation procedures, fit-for purpose analytical methods for real-world and environmentally relevant plastic mixtures, and appropriate quality controls. This is particularly the case for nanoplastics. These methodological challenges hinder robust, quantitative exposure assessments of microplastic and nanoplastic mixtures from food consumption. Furthermore, limited toxicological studies on whether microplastics and nanoplastics adversely impact human health are also impeded by methodology challenges. Food safety regulatory agencies must consider both the exposure and the risk of contaminants of emerging concern to ascertain potential harm. Foundational to this effort is access to and application of analytical methods with the capability to quantify and characterize micro-and nanoscale sized polymers in complex food matrices. However, the early stages of method development and application of early stage methods to study the distribution and potential health effects of microplastics and nanoplastics in food have largely been done without consideration of the stringent requirements of methods to inform regulatory activities. We provide regulatory science perspectives on the state of knowledge regarding the occurrence of microplastics and nanoplastics in food and present our general approach for developing, validating, and implementing analytical methods for regulatory purposes.

show abstract

Comprehensive analysis of common polymers using hyphenated TGA-FTIR-GC/MS and Raman spectroscopy towards a database for micro- and nanoplastics identification, characterization, and quantitation

Cited by 8 publications

References 63 publications

Plastic analysis with a plasmonic nano-gold sensor coated with plastic binding peptides.

Plastic analysis with a plasmonic nano-gold sensor coated with plastic binding peptides.

Plastic Analysis with a Plasmonic Nano-Gold Sensor Coated with Plastic-Binding Peptides

Regulatory Science Perspective on the Analysis of Microplastics and Nanoplastics in Human Food

Contact Info

Product

Resources

About