Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention

Guo, Mingwei; Qiu, Jin; Shen, Fei; Wang, Sainan; Yu, Jian; Zuo, Hui; Yao, Jing; Xu, Sainan; Hu, Tianhui; Wang, Dongmei; Zhao, Yu; Hu, Yepeng; Shen, Feixia; Ma, Xinran; Lü, Jian; Gu, Xuejiang; Xu, Lingyan

doi:10.18632/aging.102932

Cited by 24 publications

(19 citation statements)

References 51 publications

(47 reference statements)

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“…One recent study reported that circLMO7 regulates myoblast differentiation and survival via miR-378a-3p [ 30 ]. circBBS9 is suggested to play active roles in muscle aging by mediating the benefits of aerobic training intervention [ 31 ]. Interestingly, circRNA FUT10 has been reported to promote proliferation and inhibit cell differentiation [ 11 ], as well as to reduce proliferation and facilitate myoblast differentiation [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9

Zhu

Lian

Chen

et al. 2021

Aging

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Skeletal muscle is capable of repairing itself after injury to maintain the stability of its own tissue, but this ability declines with aging. Circular RNAs (circRNAs) are involved in cell aging. However, there is little research into their role and underlying mechanisms, especially in skeletal muscle stem cells (SkMSCs). In this study, we assessed circRNA FUT10 expression in aged and adult SkMSCs. We observed that circRNA FUT10 was upregulated in aged SkMSCs compared with that in adult SkMSCs. Furthermore, we identified putative miR-365-3p binding sites on circRNA FUT10, suggesting that this circRNA sponges miR-365a-3p. We also found that HOXA9 is a downstream target of miR-365a-3p and confirmed that miR-365a-3p can bind to circRNA FUT10 and the 3′-untranslated region of HOXA9 mRNA. This finding indicated that miR-365a-3p might serve as a “bridge” between circRNA FUT10 and HOXA9. Finally, we found that the circRNA FUT10/miR365a-3p/HOXA9 axis is involved in SkMSC aging. Collectively, our results show that the circRNA FUT10/miR365a-3p/HOXA9 axis is a promising therapeutic target and are expected to facilitate the development of therapeutic strategies to improve the prognosis of degenerative muscle disease.

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Section: Discussionmentioning

confidence: 99%

CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9

Zhu

Lian

Chen

et al. 2021

Aging

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“… 120 Additionally, a recent study found that circular Bardet-Biedl syndrome 9 (circBBS9) (decreased in aging) was elevated after exercise. 121 Bioinformatic analysis has also found that circular Bardet-Biedl syndrome 9 ( circBBS9 ) may play a positive role in muscle aging. Collectively, these results implicate both local and circulating ncRNAs in exercise-induced cardioprotection ( Fig.…”

Section: Epigenetic Landscape Of Exercise-induced Cardiac Protectionmentioning

confidence: 99%

The epigenetic landscape of exercise in cardiac health and disease

Zhang

Gao

2021

Journal of Sport and Health Science

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Highlights Exercise induces a profound alteration in epigenetics, which mediates the beneficial effects of exercise. Exercise not only modifies epigenetics in the heart to promote cardiac health, but also modifies epigenetics in other tissues, which reduces risks of cardiac disease or affords cardioprotection through exerkines. Exercise-modulated circulating non-coding RNAs are secreted from multiple tissues and shuttled by exosomes, acting as a new kind of exerkine that plays an important role in cardioprotection.

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“…Circular RNAs (circRNAs) are widely distributed in organisms and represent a type of ncRNA with a cyclic covalent structure that has a high degree of evolutionary conservation and tissue cell expression specificity [ 180 , 181 ]. circRNAs are more stable than linear RNAs due to their resistance to ribonuclease digestion [ 182 ].…”

Section: Epigenetic Modifications In Dental-derived Mscsmentioning

confidence: 99%

Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells

Chen

Zheng

Rao

et al. 2021

Stem Cells International

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As a novel research hotspot in tissue regeneration, dental-derived mesenchymal stromal cells (MSCs) are famous for their accessibility, multipotent differentiation ability, and high proliferation. However, cellular heterogeneity is a major obstacle to the clinical application of dental-derived MSCs. Here, we reviewed the heterogeneity of dental-derived MSCs firstly and then discussed the key markers and epigenetic modifications related to the proliferation, differentiation, immunomodulation, and aging of dental-derived MSCs. These messages help to control the composition and function of dental-derived MSCs and thus accelerate the translation of cell therapy into clinical practice.

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Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention

Cited by 24 publications

References 51 publications

CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9

CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9

The epigenetic landscape of exercise in cardiac health and disease

Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells

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