Comprehensive Analysis of Cell Cycle-Related Genes in Patients With Prostate Cancer

Liu, Zehua; Pan, Rongfang; Li, Wenxian; Li, Yanjiang

doi:10.3389/fonc.2021.796795

Cited by 4 publications

(2 citation statements)

References 62 publications

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“…EME2 interacts with MUS81 preferentially during the S-phase of the cell cycle, and MUS81-EME2 plays a crucial role in repairing DNA damage and maintaining genomic integrity ( 44 ). Furthermore, previous studies reported that EME2 is overexpressed in tumor tissue and was identified as poor prognosis-associated with prostate cancer ( 45 ) and gastric cancer ( 46 ). MSH4 is a meiosis-specific MutS homolog.…”

Section: Discussionmentioning

confidence: 99%

Construction of a DDR-related signature for predicting of prognosis in metastatic colorectal carcinoma

Wei

Su²,

Zhang³

et al. 2023

Front. Oncol.

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BackgroundColorectal cancer (CRC) is the third most prevalent malignancy and the one of most lethal cancer. Metastatic CRC (mCRC) is the third most common cause of cancer deaths worldwide. DNA damage response (DDR) genes are closely associated with the tumorigenesis and development of CRC. In this study, we aimed to construct a DDR-related gene signature for predicting the prognosis of mCRC patients.MethodsThe gene expression and corresponding clinical information data of CRC/mCRC patients were obtained from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. A prognostic model was obtained and termed DDRScore by the multivariate Cox proportional hazards regression in the patients with mCRC. The Kaplan-Meier (K-M) and Receiver Operating Characteristic (ROC) curves were employed to validate the predictive ability of the prognostic model. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were performed for patients between the high-DDRscore and low-DDRscore groups.ResultsWe constructed a prognostic model consisting of four DDR-related genes (EME2, MSH4, MLH3, and SPO11). Survival analysis showed that patients in the high-DDRscore group had a significantly worse OS than those in the low-DDRscore group. The area under the curve (AUC) value of the ROC curve of the predictive model is 0.763 in the training cohort GSE72970, 0.659 in the stage III/IV colorectal cancer (CRC) patients from The Cancer Genome Atlas (TCGA) data portal, and 0.639 in another validation cohort GSE39582, respectively. GSEA functional analysis revealed that the most significantly enriched pathways focused on nucleotide excision repair, base excision repair, homologous recombination, cytokine receptor interaction, chemokine signal pathway, cell adhesion molecules cams, ECM-receptor interaction, and focal adhesion.ConclusionThe DDRscore was identified as an independent prognostic and therapy response predictor, and the DDR-related genes may be potential diagnosis or prognosis biomarkers for mCRC patients.

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Section: Discussionmentioning

confidence: 99%

Construction of a DDR-related signature for predicting of prognosis in metastatic colorectal carcinoma

Wei

Su²,

Zhang³

et al. 2023

Front. Oncol.

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“…[ 37 ] Complementary analyses included sourcing NCS1 expression data from the Human Protein Atlas (HPA). [ 38 ] and conducting real‐time quantitative PCR (rt‐qPCR) to quantify TOP mRNA in sarcoma cell lines HT‐1080 and SW‐982. Statistical integrity was maintained through ANOVA and nonparametric testing, linking clinicopathological parameters with co‐expression patterns.…”

Section: Methodsmentioning

confidence: 99%

Genomic Insights into the Role of TOP Gene Family in Soft‐Tissue Sarcomas: Implications for Prognosis and Therapy

Wang,

Gan,

Chen

et al. 2024

Advanced Biology

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This study focuses on the role of topoisomerases (TOPs) in sarcomas (SARCs), highlighting TOPs' influence on sarcoma prognosis through mRNA expression, genetic mutations, immune infiltration, and DNA methylation analysis using transcriptase sequencing and other techniques. The findings indicate that TOP gene mutations correlate with increased inflammation, immune cell infiltration, DNA repair abnormalities, and mitochondrial fusion genes alterations, all of which negatively affect sarcoma prognosis. Abnormal TOP expression may independently affect sarcoma patients' survival. Cutting‐edge genomic tools such as Oncomine, gene expression profiling interactive analysis (GEPIA), and cBio Cancer Genomics Portal (cBioPortal) are utilized to explore the TOP gene family (TOP1/1MT/2A/2B/3A/3B) in soft‐tissue sarcomas (STSs). This in‐depth analysis reveals a notable upregulation of TOP mRNA in STS patients arcoss various SARC subtypes, French Federation Nationale des Centres de Lutte Contre le Cancer classification (FNCLCC) grades, and specific molecular profiles correlating with poorer clinical outcomes. Furthermore, this investigation identifies distinct patterns of immune cell infiltration, genetic mutations, and somatic copy number variations linked to TOP genes that inversely affect patient survival rates. These findings underscore the diagnostic and therapeutic relevance of the TOP gene suite in STSs.

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Research Progress of the Function of CDCA5 and Its Role in Cancer Progression

范

2023

ACM

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Comprehensive Analysis of Cell Cycle-Related Genes in Patients With Prostate Cancer

Cited by 4 publications

References 62 publications

Construction of a DDR-related signature for predicting of prognosis in metastatic colorectal carcinoma

Construction of a DDR-related signature for predicting of prognosis in metastatic colorectal carcinoma

Genomic Insights into the Role of TOP Gene Family in Soft‐Tissue Sarcomas: Implications for Prognosis and Therapy

Research Progress of the Function of CDCA5 and Its Role in Cancer Progression

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