Comprehensive analysis of autophagy-related clusters and individual risk model for immunotherapy response prediction in gastric cancer

Yao, Yanxin; Hu, Xin; Ma, Junfu; Wu, Liuxing; Chen, Kexin; Liu, Ben

doi:10.3389/fonc.2023.1105778

Cited by 3 publications

(2 citation statements)

References 66 publications

(53 reference statements)

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“…who performed a genetic screening on several cancer cell lines treated with Bispecific T-cell engagers and revealed that a change of autophagy-related genes is involved in their limited anti-tumor effect [ 204 ]. They and others also demonstrate how autophagy pathways could be shaped by tumor cells following therapies, for example, predisposing the generation of a cold tumor microenvironment [ 205 – 207 ].…”

Section: Potential Clinical Application For Adoptive Cell-therapymentioning

confidence: 99%

Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies

Giansanti,

Theinert,

Boeing

et al. 2023

Mol Cancer

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Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to viral infection, playing a key role in human health and disease. At present, a growing number of evidence suggests a role of autophagy as a primitive innate immune form of defense for eukaryotic cells, interacting with components of innate immune signaling pathways and regulating thymic selection, antigen presentation, cytokine production and T/NK cell homeostasis. In cancer, autophagy is intimately involved in the immunological control of tumor progression and response to therapy. However, very little is known about the role and impact of autophagy in T and NK cells, the main players in the active fight against infections and tumors. Important questions are emerging: what role does autophagy play on T/NK cells? Could its modulation lead to any advantages? Could specific targeting of autophagy on tumor cells (blocking) and T/NK cells (activation) be a new intervention strategy? In this review, we debate preclinical studies that have identified autophagy as a key regulator of immune responses by modulating the functions of different immune cells and discuss the redundancy or diversity among the subpopulations of both T and NK cells in physiologic context and in cancer.

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Section: Potential Clinical Application For Adoptive Cell-therapymentioning

confidence: 99%

Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies

Giansanti,

Theinert,

Boeing

et al. 2023

Mol Cancer

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show abstract

“…Additionally, it is well-recognized that oxidative stress can initiate autophagy. Yao et al attempted to investigate novel autophagy-related clusters and create a multi-gene signature for GC that could predict prognosis and immunotherapy response [184]. Using consensus clustering, a total of 1505 individuals from eight GC cohorts were divided into two subgroups.…”

Section: Gastric Cancermentioning

confidence: 99%

Redox Signaling Modulates Activity of Immune Checkpoint Inhibitors in Cancer Patients

et al. 2023

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Although immunotherapy is already a staple of cancer care, many patients may not benefit from these cutting-edge treatments. A crucial field of research now focuses on figuring out how to improve treatment efficacy and assess the resistance mechanisms underlying this uneven response. For a good response, immune-based treatments, in particular immune checkpoint inhibitors, rely on a strong infiltration of T cells into the tumour microenvironment. The severe metabolic environment that immune cells must endure can drastically reduce effector activity. These immune dysregulation-related tumour-mediated perturbations include oxidative stress, which can encourage lipid peroxidation, ER stress, and T regulatory cells dysfunction. In this review, we have made an effort to characterize the status of immunological checkpoints, the degree of oxidative stress, and the part that latter plays in determining the therapeutic impact of immunological check point inhibitors in different neoplastic diseases. In the second section of the review, we will make an effort to assess new therapeutic possibilities that, by affecting redox signalling, may modify the effectiveness of immunological treatment.

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Identification of an autophagy- and macropinocytosis-related prognostic signature for the prediction of prognosis and therapeutic response in gastric cancer

Shi,

Qiu,

Cui

et al. 2024

Genes Genom

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Comprehensive analysis of autophagy-related clusters and individual risk model for immunotherapy response prediction in gastric cancer

Cited by 3 publications

References 66 publications

Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies

Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies

Redox Signaling Modulates Activity of Immune Checkpoint Inhibitors in Cancer Patients

Identification of an autophagy- and macropinocytosis-related prognostic signature for the prediction of prognosis and therapeutic response in gastric cancer

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