Comprehensive analysis and experimental verification of LINC01314 as a tumor suppressor in hepatoblastoma

Lv, Benji; Zhang, Lianhai; Miao, Runchen; Xiang, Xiaohong; Dong, Shunbin; Lin, Ting; Li, Ké; Qu, Kai

doi:10.1016/j.biopha.2018.01.013

Cited by 26 publications

(21 citation statements)

References 29 publications

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“…In many of these situations, lack of availability of the actual Yale-Penn lead SNPs in other samples likely diminished the statistical significance of the final meta-analyzed results. Overexpression of LINC01314 was recently shown to act as a tumor suppressor in hepatoblastoma, possibly through the Hippo-YAP signaling pathway 42 . This pathway has been previously implicated in psychiatric conditions such as schizophrenia and anxiety through one of its key effectors, the “Nitric Oxide Synthase 1 Adaptor Protein” ( NOS1AP) .…”

Section: Discussionmentioning

confidence: 99%

Genetic associations with suicide attempt severity and genetic overlap with major depression

et al. 2019

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In 2015, ~800,000 people died by suicide worldwide. For every death by suicide there are as many as 25 suicide attempts, which can result in serious injury even when not fatal. Despite this large impact on morbidity and mortality, the genetic influences on suicide attempt are poorly understood. We performed a genome-wide association study (GWAS) of severity of suicide attempts to investigate genetic influences. A discovery GWAS was performed in Yale-Penn sample cohorts of European Americans (EAs, n = 2,439) and African Americans (AAs, n = 3,881). We found one genome-wide significant (GWS) signal in EAs near the gene LDHB (rs1677091, p = 1.07 × 10−8) and three GWS associations in AAs: ARNTL2 on chromosome 12 (rs683813, p = 2.07 × 10−8), FAH on chromosome 15 (rs72740082, p = 2.36 × 10−8), and on chromosome 18 (rs11876255, p = 4.61 × 10−8) in the Yale-Penn discovery sample. We conducted a limited replication analysis in the completely independent Army-STARRS cohorts. rs1677091 replicated in Latinos (LAT, p = 6.52 × 10−3). A variant in LD with FAH rs72740082 (rs72740088; r2 = 0.68) was replicated in AAs (STARRS AA p = 5.23 × 10−3; AA meta, 1.51 × 10−9). When combined for a trans-population meta-analysis, the final sample size included n = 20,153 individuals. Finally, we found significant genetic overlap with major depressive disorder (MDD) using polygenic risk scores from a large GWAS (r2 = 0.007, p = 6.42 × 10−5). To our knowledge, this is the first GWAS of suicide attempt severity. We identified GWS associations near genes involved in anaerobic energy production (LDHB), circadian clock regulation (ARNTL2), and catabolism of tyrosine (FAH). These findings provide evidence of genetic risk factors for suicide attempt severity, providing new information regarding the molecular mechanisms involved.

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Section: Discussionmentioning

confidence: 99%

Genetic associations with suicide attempt severity and genetic overlap with major depression

et al. 2019

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“…To find the gene modules associated with our risk scores, we construct a co-expression network using the R package “WGCNA” according to our previous reports [ 28 ]. The soft thresholding power was selected to 9 to produce a weighted network.…”

Section: Methodsmentioning

confidence: 99%

A seven-long noncoding RNA signature predicts overall survival for patients with early stage non-small cell lung cancer

Lin

Zhang

et al. 2018

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Non-small cell lung cancer (NSCLC) is the most common cancer and cause of cancer-related mortality globally. Increasing evidence suggested that the long non-coding RNAs (lncRNAs) were involved in cancer-related death. To explore the possible prognostic lncRNA biomarkers for NSCLC patients, in the present study, we conducted a comprehensive lncRNA profiling analysis based on 1902 patients from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets. In the discovery phase, we employed 682 patients from the combination of four GEO datasets (GSE30219, GSE31546, GSE33745 and GSE50081) and conducted a seven-lncRNA formula to predict overall survival (OS). Next, we validated our risk-score formula in two independent datasets, TCGA (n=994) and GSE31210 (n=226). Stratified analysis revealed that the seven-lncRNA signature was significantly associated with OS in stage I patients from both discovery and validation groups (all P<0.001). Additionally, the prognostic value of the seven-lncRNA signature was also found to be favorable in patients carrying wild-type KRAS or EGFR. Bioinformatical analysis suggested that the seven-lncRNA signature affected patients’ prognosis by influencing cell cycle-related pathways. In summary, our findings revealed a seven-lncRNA signature that predicted OS of NSCLC patients, especially in those with early tumor stage and carrying wild-type KRAS or EGFR.

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“…The annotation of noncoding RNA transcripts, including 8240 lncRNA transcripts, was obtained according to our previous study. 14 We selected HB samples carrying CTNNB1 mutation for WGCNA. 15 The clinical features included race, age, gender, HB subtype, Cairo Classification, tumor stage and histology, and prognostic characteristics.…”

Section: Weighted Correlation Network Analysis (Wgcna)mentioning

confidence: 99%

“…Previous studies have demonstrated that the above three features affected patients' prognosis. 14 The highly coexpressed genes in the purple module have potential biological significance in CTNNB1-mutated HB. Therefore, we selected the genes in MEpurple module for further investigations.…”

Section: Identification Of Differentially Expressed Genes That Were Amentioning

confidence: 99%

<p>TUG1 Promoted Tumor Progression by Sponging miR-335-5p and Regulating CXCR4-Mediated Infiltration of Pro-Tumor Immunocytes in CTNNB1-Mutated Hepatoblastoma</p>

Xie

Zhang

Yao

et al. 2020

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Introduction: HB presents with the highest frequency of CTNNB1 mutations, resulting in activation of Wnt signaling pathway. A number of studies have demonstrated CTNNB1 mutation contributed to the development of HB. However, limited research explored the function of lncRNAs in HB with CTNNB1 mutation. Methods: We screened lncRNA expression profiles in CTNNB1-mutated HB samples and identified lncRNAs associated with malignant phenotype in HB. The association between lncRNA and immune microenvironment was investigated. The biological function of lncRNA was further explored using in vitro experiments. Results: TUG1 was identified as onco-lncRNA in CTNNB1-mutated HB. TUG1 was shown to be associated with the infiltration of pro-tumor immunocytes via regulating the expression of CXCR4, a chemokine receptor playing a critical role in regulation of immune microenvironment. Inhibiting TUG1 could increase endogenous levels of miR-335-5p and consequently downregulating CXCR4, a direct target of miR-335-5p. Conclusion: Our findings provide evidence for TUG1 mediating infiltration of pro-tumor immunocytes in HB patients carrying CTNNB1 mutation. TUG1-miR-335-5p-CXCR4 axis might be a promising immunological target for the treatment of HB patients.

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Comprehensive analysis and experimental verification of LINC01314 as a tumor suppressor in hepatoblastoma

Cited by 26 publications

References 29 publications

Genetic associations with suicide attempt severity and genetic overlap with major depression

Genetic associations with suicide attempt severity and genetic overlap with major depression

A seven-long noncoding RNA signature predicts overall survival for patients with early stage non-small cell lung cancer

<p>TUG1 Promoted Tumor Progression by Sponging miR-335-5p and Regulating CXCR4-Mediated Infiltration of Pro-Tumor Immunocytes in CTNNB1-Mutated Hepatoblastoma</p>

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