Comprehensive Analyses of Prognostic Values and Immune Infiltration of KDM3 Gene Family in Hepatocellular Carcinoma

Lin, Gang-Hua; Wu, Shu-Hsien; Ko, Yu-Chun; Lin, Chien-Hua; Liao, Guo‐Shiou; Chen, Teng-Wei; Chen, Yen-Ju; Hsu, Kuo–Feng

doi:10.1007/s12033-022-00568-z

Cited by 1 publication

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of publicly available RNA-sequencing and clinical tissue sample data shows that KDM3B is overexpressed in liver tissues of HCC patients compared to the matched normal tissues [ 18 , 33 ]. Knockout of KDM3B hampers cell cycle progression and proliferation of HCC cells [ 18 ].…”

Section: The Role Of Kdm3b In Tumorigenesismentioning

confidence: 99%

“…Inhibition of KDM3B expression in HCC by miR-1307 promotes hepatocarcinogenesis by enhancing the expression of endoplasmic-reticulum-related gene, CALR , disrupting the normal functioning of endoplasmic-reticulum [ 36 ]. While other studies highlight the role of KDM3B in HCC, one study undermines the role of KDM3B in HCC tumorigenesis, as there seems to be no significant correlation between KDM3B expression levels and HCC patient survival rates [ 33 ]. These results indicate that further studies need to be conducted to solidify the function of KDM3B in HCC.…”

Section: The Role Of Kdm3b In Tumorigenesismentioning

confidence: 99%

See 1 more Smart Citation

Epigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications

Yoo,

Kim,

Jeon

et al. 2024

Cell Death Dis

View full text Add to dashboard Cite

Advances in functional studies on epigenetic regulators have disclosed the vital roles played by diverse histone lysine demethylases (KDMs), ranging from normal development to tumorigenesis. Most of the KDMs are Jumonji C domain-containing (JMJD) proteins. Many of these KDMs remove methyl groups from histone tails to regulate gene transcription. There are more than 30 known KDM proteins, which fall into different subfamilies. Of the many KDM subfamilies, KDM3 (JMJD1) proteins specifically remove dimethyl and monomethyl marks from lysine 9 on histone H3 and other non-histone proteins. Dysregulation of KDM3 proteins leads to infertility, obesity, metabolic syndromes, heart diseases, and cancers. Among the KDM3 proteins, KDM3A has been largely studied in cancers. However, despite a number of studies pointing out their importance in tumorigenesis, KDM3B and KDM3C are relatively overlooked. KDM3B and KDM3C show context-dependent functions, showing pro- or anti-tumorigenic abilities in different cancers. Thus, this review provides a thorough understanding of the involvement of KDM3B and KDMC in oncology that should be helpful in determining the role of KDM3 proteins in preclinical studies for development of novel pharmacological methods to overcome cancer.

show abstract

Section: The Role Of Kdm3b In Tumorigenesismentioning

confidence: 99%

Section: The Role Of Kdm3b In Tumorigenesismentioning

confidence: 99%