“…However, a strong association was detected between the Cys326Cys risk genotype and cardiovascular mortality. Although in comparison to studies that have examined the possible association between the OGG1-rs1052133 polymorphism and cancer [18][19][20][21][22][23][24][25][26][27][28][29][30][31] , very few have examined its association with cardiovascular disease [33][34][35]54 , studies in animal models on OGG1 function strongly support this association 32,59,60 . Thus, in a study by Tumurkhuu et al 32 in Ogg1(-/-) mice, the authors observed a more atherogenic profile of the different markers analyzed in comparison with mice with a normal Ogg1 gene expression.…”