Comprehending the role of LPS in Gram-negative bacterial vaginosis: ogling into the causes of unfulfilled child-wish

Deb, Kaushik; Chaturvedi, Madan M.; Jaiswal, Yogesh K.

doi:10.1007/s00404-004-0623-0

Cited by 49 publications

(40 citation statements)

References 73 publications

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“…LPS is the most potent antigenic component of the gramnegative bacterial cell wall. Genital tract infection/ vaginitis caused by Gram-negative bacteria is one of the major causes of gynecologic morbidity, such as infertility, ectopic pregnancy, preterm labor and chronic pelvic pain [3,4]. Beside this, systemic gram-negative bacterial infections like typhoid fever caused by Salmonella typhi, during pregnancy can cause several perinatal complications and preterm labor.…”

Section: Introductionmentioning

confidence: 99%

Gram‐Negative Bacterial LPS Induced Poor Uterine Receptivity andImplantation Failure in Mouse: Alterations in IL‐1β Expression in the Preimplantation Embryo and Uterine Horns

Deb

Chaturvedi

Jaiswal

2005

Infectious Diseases in Obstetrics and Gynecology

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Genito-urinary tract or systemic infections of the gram-negative bacteria in pregnant women, causes abortions, preterm labor, and several other perinatal complications. LPS is the most potent antigenic component of the gram-negative bacterial cell wall and is known to modulate the expression of various proinflammatory cytokines. Here we investigate the role of the soluble form of IL-1 i.e., IL-1beta in the 'minimum dose' of LPS induced pregnancy loss in mice. Uterine cross-sections on each day of the preimplantation period of pregnancy were examined histopathologically for finding out LPS induced changes in the uterine preparation for embryo implantation. The expression of IL-1beta in the various stages of the preimplantation period of pregnancy was studied by RT-PCR in the embryos and the uterine horns of the LPS treated and normal pregnant mice. We found that LPS significantly alters the proliferation of the glandular epithelium, luminal epithelium and stroma during the preimplantation period. We also found large infiltration of macrophages into the uterine horns of the LPS treated animals. The level and pattern of IL-1beta expression in the preimplantation embryos and uterine horns were also altered in LPS treated animals. These observations indicate that LPS can alter the uterine preparation for blastocyst implantation, which could be due to the change in the IL-1beta expression in the uterine horns. However, a change in the expression pattern of IL-1beta in the preimplantation embryos underlines the significance of this molecule in LPS induced pregnancy loss or implantation failure in mouse.

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Section: Introductionmentioning

confidence: 99%

Gram‐Negative Bacterial LPS Induced Poor Uterine Receptivity andImplantation Failure in Mouse: Alterations in IL‐1β Expression in the Preimplantation Embryo and Uterine Horns

Deb

Chaturvedi

Jaiswal

2005

Infectious Diseases in Obstetrics and Gynecology

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“…Lipopolysaccharide (LPS) is a component of the outer membrane of gram-negative bacteria, exhibits a variety of toxic and proinflammatory activities related to the pathogenesis of gramnegative bacterial infection (7)(8)(9)(10)(11)(12)(13)(14), and is associated with adverse developmental outcome including embryonic resorption and preterm delivery (7,15). We established a gram-negative bacterial infection model in the mouse in which the intraperitoneal injection of LPS (250 mg/kg body weight on day 0.5 of pregnancy) causes embryonic cell death (16) and leads to implantation failure on day 5.5 of pregnancy (17).…”

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confidence: 99%

Lipopolysaccharide induces alterations in ovaries and serum level of progesterone and 17β-estradiol in the mouse

Agrawal

Jaiswal

2011

Fertility and Sterility

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“…5 The bacterial flora that characterise bacterial vaginosis have been recovered from the endometria and salpinges of women with pelvic inflammatory disease (PID). 19 We found the presence of bacterial vaginosis was associated with testing positive for other infections. In our study women testing positive for bacterial vaginosis were twice as likely to have trichomoniasis, chlamydia and/ or gonorrhea.…”

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confidence: 73%

Reproductive tract infections associated with vaginal discharge and their socio-demographic and reproductive determinants among clinic attendees in Bangladesh

Rahman

Currie

Breiman

et al. 2013

SE Asia J. Pub. Health

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Abnormal vaginal discharge is frequently associated with common sexually and non-sexually transmitted reproductive tract infections (RTIs) and the resultant poor reproductive health outcomes. However, there is scarce information concerning the prevalence and etiologies of these infections in women in Bangladesh. The aim of study was to determine the rates of, and socio-demographic and reproductive characteristics associated with, common RTIs in urban public health clinics in Dhaka, Bangladesh. An urban clinic-based sample of 1309 currently married women of reproductive age presenting with abnormal vaginal discharge was recruited. Consenting women were interviewed and tested for Candida, bacterial vaginosis, Trichomonas vaginalis, Neisseria gonorrhoeae and Chlamydia trachomatis during a speculum examination. Approximately 53% (673/1309) of the participants had laboratory evidence of RTIs. The prevalence of Candida, bacterial vaginosis, T. vaginalis, N. gonorrhoeae and C. trachomatis were 32.4%, 22.4%, 3.1%, 2.1 %, 1.9% respectively. Age, education, living in a slum, working outside the home, polygamous marriage and suspecting infidelity were independently associated with vaginal and cervical infections. Candidiasis and bacterial vaginosis were the most common infections in this population. Paying attention to the socio-demographic and reproductive characteristics found to be associated with RTIs can assist clinicians in identifying women at risk of these infections.

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Comprehending the role of LPS in Gram-negative bacterial vaginosis: ogling into the causes of unfulfilled child-wish

Abstract: Once these inflammatory mediators have increased in the feto-maternal tissues, it may be too late or harmful to try and prevent the adverse outcomes of pregnancy.

Cited by 49 publications

References 73 publications

Gram‐Negative Bacterial LPS Induced Poor Uterine Receptivity andImplantation Failure in Mouse: Alterations in IL‐1β Expression in the Preimplantation Embryo and Uterine Horns

Gram‐Negative Bacterial LPS Induced Poor Uterine Receptivity andImplantation Failure in Mouse: Alterations in IL‐1β Expression in the Preimplantation Embryo and Uterine Horns

Lipopolysaccharide induces alterations in ovaries and serum level of progesterone and 17β-estradiol in the mouse

Reproductive tract infections associated with vaginal discharge and their socio-demographic and reproductive determinants among clinic attendees in Bangladesh

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