Compounds in functional food fenugreek spice exhibit anti-inflammatory and antioxidant activities

Replacement of dietary fishmeal for fenugreek seed meal on the growth, body composition, innate immunological responses and gene expression of hepatic insulin‐like growth factors in African catfish ( Clarias gariepinus )

“…In S. aurata , fenugreek seeds at 50 g/kg were shown to significantly enhance various immunological responses that included natural haemolytic complement activity, peroxidase activity, immunoglobulin gene expression and skin mucosa protease activity (Bahi et al., ; Guardiola et al., ). These authors’ suggested possible reasons for their findings included various bioactive compounds within FKSM that include flavonoids, alkaloids and volatile oils that have anti‐inflammatory and antioxidant properties (Liu, Kakani, & Nair, ; Wani & Kumar, ). A more systematic analysis of the innate immunity should be performed in C. gariepinus after being fed these FKSM diets to better assess their overall health.…”

In Vitro Cytotoxic Activity of Seed Oil of Fenugreek Against Various Cancer Cell Lines

“…Several alkaloids and these groups of compounds characterized by showing cancer inhibiting activity have been studied (Fawzy, 1994), and are effective in the treatment of some of the most common forms of brain and optic nerve tumors (Danna, 2006). The biologically active components present in fenugreek seeds having the anti-inflammatory and antioxidant activities have also been studied (Liu et al, 2012). The morphological changes in the cells were observed more prominent in treated cells showing extensive blebbing and vacuolation suggesting autophagic mechanism of cell death (Vijayarathna, 2012).…”

“…In recent research, fenugreek seeds were experimentally shown to protect against breast (Amin et al, 2005) and colon cancers (Raju et al, 2006). Active components and their biological activities of isolates of the fenugreek seeds showing the antioxidant and anti-inflammatory activities have already been reported (Liu et al, 2012). Therefore, present study was designed to investigate the cytotoxicity of fenugreek seed oil against the four cell lines, i.e.…”

Fenugreek

“…For exploring the mechanism of antiinflammatory effects of fenugreek, Liu et al (2012) investigated the effect of fenugreek seed extracts (hexane, ethyl acetate, methanolic, and water extracts) on lipid peroxidation (LPO) and cyclooxygenase (COX) enzyme inhibitory activities using MTT, LPO, COX1, and COX2 enzyme inhibitory assays. The extracts inhibited LPO by 55-95%, COX1 by 6-87%, and COX2 by 36-70%, respectively, at a level of 250 µg/mL.…”