Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Simoben, Conrad V.; Ntie‐Kang, Fidele; Akoné, Sergi Hervé; Sippl, Wolfgang

doi:10.1007/s13659-018-0165-y

Cited by 42 publications

(24 citation statements)

References 150 publications

(125 reference statements)

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“…Since the first bioactive isoquinoline alkaloid, morphine, was isolated from the opium plant in the early 19th century, 3 this compound class has attracted considerable scientific attention. Increasing numbers of isoquinoline alkaloids have been isolated and identified from natural sources, and various studies have reported their antitumor, antimalarial, antibacterial, antifungal, antiparasitic and insecticidal, antiviral, anti‐inflammatory, antiplatelet, and other activities 4–12 13 as reflected by several revolutionary drugs, such as the analgesic morphine, the antibacterial berberine, the antitussive codeine, 14 the antirheumatic sinomenine, 15 and the acetylcholinesterase inhibitor galanthamine 16 (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

116

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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Section: Introductionmentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

116

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“…In particular, several plants from the Asteraceae family have provided some lead compounds against Leishmania spp. [5,6]. Specifically, Tagetes lucida Cav.…”

Section: Introductionmentioning

confidence: 99%

Antileishmanial Activity and Influence on Mitochondria of the Essential Oil from Tagetes lucida Cav. and Its Main Component

et al. 2020

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Current antileishmanial drugs are toxic, expensive, and resistance to them has emerged. Several studies have focused on natural products as alternatives. In the present work, the chemical composition, in vitro antileishmanial activity, cytotoxicity effects, and the influence on mitochondrial function of the essential oil from Tagetes lucida Cav. was determined, as well its main compound estragole. Forty-nine compounds were detected in the oil by gas chromatography-mass spectrometry (GC-MS), of which estragole was the main constituent (97%). The oil showed inhibition of the promastigotes of L. tarentolae and L. amazonensis (IC50 = 61.4 and 118.8 µg/mL, respectively), decreased oxygen consumption of L. tarentolae, disrupted mitochondrial membrane potential in L. amazonensis, inhibitory activity on the intracellular amastigote of L. amazonensis (IC50 = 14.2 ± 1.6 µg/mL), and cytotoxicity values ranging from 80.8 to 156 µg/mL against murine macrophages and J774 cells. Estragole displayed higher activity on promastigotes (IC50 = 28.5 and 25.5 µg/mL, respectively), amastigotes (IC50 = 1.4 ± 0.1 µg/mL), and cytotoxicity values ranging from 20.6 to 14.5 µg/mL, respectively, while on mitochondria, it caused a decrease of the membrane potential but did not inhibit oxygen consumption. The potential antileishmanial activity of the essential oil from T. lucida and estragole makes these compounds favorable candidates for exploration in further studies.

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“…In addition, in many countries, the control of schistosomiasis is not integral of the national budget, meaning that resources are limited to overcome the morbidity and mortality associated with the disease [41,42,47]. Given the limitation in available resources and the fact that there is no available vaccine for this disease, there is a dire need to develop alternative medicines that are both cost-effective and treatment-effective for this disease [48,49]. In this advent, natural products present an interesting opportunity toward the development of novel pharmacological agents to triumph over this disease.…”

Section: Biological Control Of Intermediate Hosts As An Alternative Waymentioning

confidence: 99%

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions

Albuquerque

Mahomoodally

Lobine

et al. 2020

Biology

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Schistosomiasis, a parasitic disease caused by trematodes of the genus Schistosoma, is the second most prevalent parasitic disease in the world. It affects around 200 million people. Clinical treatment, prophylaxis, and prevention are performed in countries susceptible to schistosomiasis. In the pharmacological treatment for an acute form of schistosomiasis, the use of antiparasitics, mainly praziquantel, is more common. As an alternative way, prevention methods such as reducing the population of intermediate hosts (mollusks) with molluscicides are important in the control of this disease by interrupting the biological cycle of this etiological parasite. Despite the importance of pharmacological agents and molluscicides, they have side effects and environmental toxicity. In addition, they can lead to the development of resistance enhancing of parasites, and lead to the search for new and effective drugs, including resources of vegetal origin, which in turn, are abundant in the affected countries. Thus, the purpose of this review is to summarize recent studies on botanical products with potential for the control of schistosomiasis, including anti-Schistosoma and molluscicide activities. In addition, species and plant derivatives according to their origin or geographical importance indicating a possible utility of local resources for countries most affected by the disease are presented.

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Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cited by 42 publications

References 150 publications

Biologically active isoquinoline alkaloids covering 2014–2018

Biologically active isoquinoline alkaloids covering 2014–2018

Antileishmanial Activity and Influence on Mitochondria of the Essential Oil from Tagetes lucida Cav. and Its Main Component

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions

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