Compound Shape and Substituent Effects in DNA Minor Groove Interactions

Wilson, W. David

doi:10.1007/978-981-16-1313-5_29-1

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Extension To Gc Base Pair Recognition1

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2023

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“…The lead compounds have strong binding and excellent mixed sequence binding specificity for a GC base pair flanked by AT base pair DNA sequences (Paul et al, 2019, Wilson & Paul 2022). The goal of the design of these new minor groove binding agents is the recognition of biologically important DNA sequences.…”

Section: Extension To Gc Base Pair Recognitionmentioning

confidence: 99%

Binding to the DNA Minor Groove by Heterocyclic Dications: from AT Specific to GC Recognition Compounds

Nanjunda

Wilson

2023

Current Protocols

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Compounds that bind in the DNA minor groove have provided critical information on DNA molecular recognition, have found extensive uses in biotechnology, and are providing clinically useful drugs against diseases as diverse as cancer and sleeping sickness. This review focuses on the development of clinically useful heterocyclic diamidine minor groove binders. These compounds show that the classical model for minor groove binding in AT DNA sequences must be expanded in several ways: compounds with nonstandard shapes can bind strongly to the groove, water can be directly incorporated into the minor groove complex in an interfacial interaction, compounds can be designed to recognize GC and mixed AT/GC base pair sequences, and stacked dimers can form to recognize specific sequences. © 2023 Wiley Periodicals LLC.

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Section: Extension To Gc Base Pair Recognitionmentioning

confidence: 99%