Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism

Tian, Fengyuan; Huang, Shuo; Xu, Wangda; Chen, Lan; Su, Jianming; Ni, Haixiang; Feng, Xiaohong; Chen, Jie; Wang, Xi; Huang, Qi

doi:10.1016/j.jgr.2022.03.006

Cited by 18 publications

(15 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously reported, [ 20 ] the size and composition of BA pools were detected by ultra‐high‐performance liquid chromatography‐mass spectrometry (UPLC‐MS). Briefly, an aliquot of 10 mg of content sample was added to a 200 µL mixed solution of methanol and acetonitrile (v/v, 8:2) followed by centrifugation (4 °C, 13 500 × g , 20 min).…”

Section: Methodsmentioning

confidence: 99%

Curcumin Compensates GLP‐1 Deficiency via the Microbiota‐Bile Acids Axis and Modulation in Functional Crosstalk between TGR5 and FXR in ob/ob Mice

Tian,

Chen,

et al. 2023

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

ScopeGlucagon‐like peptide‐1 (GLP‐1) deficiency occurs in obesity‐related pathologies due to defects in the intestinal lumen. And expanding the L‐cell population has emerged as a promising avenue to elevate GLP‐1 secretion to tackle metabolic disorders. Curcumin (Cur), the principal active component of spice turmeric, possesses well‐established anti‐obesity properties. To clarify, the study investigates whether Cur promotes GLP‐1 secretion built upon the L‐cell expansion.Methods and resultsCur (60 mg kg−1) is administered orally to male ob/ob mice for 8 weeks. Cur ameliorates obesity and impaires glucose tolerance through increasing energy expenditure in ob/ob mice, accompanied by the maintenance of crypt architecture and gut permeability. It refines the microbial structure and bile acid (BA) profiles, resulting in deoxycholic acid (DCA) accumulation by weakening the enrichment of Lactobacillus. Further analyses show radically different properties of Cur on the intestine function of TGR5 and FXR (i.e., activation and repression). Cur amplifies L‐cell number to promote GLP‐1 secretion in ob/ob mice.ConclusionsThe findings suggest that Cur may act as a natural TGR5 agonist and FXR antagonist to improve obesity by enhancing GLP‐1 release from L‐cell expansion via the gut microbiota‐BAs‐TGR5/FXR axis, and it may serve as a promising therapeutic agent to compensate obesity‐related metabolic disorders.

show abstract

Section: Methodsmentioning

confidence: 99%

Curcumin Compensates GLP‐1 Deficiency via the Microbiota‐Bile Acids Axis and Modulation in Functional Crosstalk between TGR5 and FXR in ob/ob Mice

Tian,

Chen,

et al. 2023

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…The effect of red ginseng supplementation was reflected in the serum, white adipose tissue, and ileum bile acid profiles, although no significant changes in the composition of hepatic bile acid were observed. In another study, ginsenoside compound K activated TGR5 in the L-cells of the intestinal epithelium, possibly via the gut microbiota–bile acid axis . The intervention of compound K significantly facilitated the growth of Akkermansia , Lactobacillaceae , Lachnospiraceae , and Ruminococcaceae and simultaneously reduced the abundance of Bacteroidaceae and Enterococcaceae .…”

Section: Association Of Bile Acids With Cholesterol Homeostasismentioning

confidence: 99%

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Weerawatanakorn,

Kamchonemenukool,

Koh

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Although cholesterol plays a key role in many physiological processes, its dysregulation can lead to several metabolic diseases. Statins are a group of drugs widely used to lower cholesterol levels and cardiovascular risk but may lead to several side effects in some patients. Therefore, the development of a plant-based therapeutic adjuvant with cholesterol-lowering activity is desirable. The maintenance of cholesterol homeostasis encompasses multiple steps, including biosynthesis and metabolism, uptake and transport, and bile acid metabolism; issues arising in any of these processes could contribute to the etiology of cholesterolrelated diseases. An increasing body of evidence strongly indicates the benefits of phytochemicals for cholesterol regulation; traditional Chinese medicines prove beneficial in some disease models, although more scientific investigations are needed to confirm their effectiveness. One of the main functions of cholesterol is bile acid biosynthesis, where most bile acids are recycled back to the liver. The composition of bile acid is partly modulated by gut microbes and could be harmful to the liver. In this regard, the reshaping effect of phytochemicals on gut microbiota has been widely reported in the literature for its significance. Therefore, we reviewed studies conducted over the past 5 years elucidating the regulatory effects of phytochemicals or herbal medicines on cholesterol metabolism. In addition, their effects on the recomposition of gut microbiota and bile acid metabolism due to modulation are discussed. This review aims to provide novel insights into the treatment of cholesterol dysregulation and the anticipated development of natural-based compounds in the near and far future.

show abstract

“…Bile acids can act on Takeda G-protein-coupled receptor 5 (TGR5) and farnesoid X (FXR), and the dual activation of TGR5 and FXR can effectively promote lipid and glucose metabolism and prevent the emergence of various metabolic diseases [ 90 , 91 , 92 ]. In addition, further studies have found that activation of TGR5 also improves the body’s sensitivity to insulin and that secondary bile acids also act on TGR5 on intestinal L cells to promote GLP-1 production, which plays a key role in promoting glucose metabolism, which has significant implications for the prevention of diabetes [ 93 , 94 ].…”

Section: The Role Of Gut Microbiota In Metabolic Disordersmentioning

confidence: 99%

Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat Metabolic Disorders to Maintain Health

et al. 2023

View full text Add to dashboard Cite

Each person’s body is host to a large number and variety of gut microbiota, which has been described as the second genome and plays an important role in the body’s metabolic process and is closely related to health. It is common knowledge that proper physical activity and the right diet structure can keep us healthy, and in recent years, researchers have found that this boost to health may be related to the gut microbiota. Past studies have reported that physical activity and diet can modulate the compositional structure of the gut microbiota and further influence the production of key metabolites of the gut microbiota, which can be an effective way to improve body metabolism and prevent and treat related metabolic diseases. In this review, we outline the role of physical activity and diet in regulating gut microbiota and the key role that gut microbiota plays in improving metabolic disorders. In addition, we highlight the regulation of gut microbiota through appropriate physical exercise and diet to improve body metabolism and prevent metabolic diseases, aiming to promote public health and provide a new approach to treating such diseases.

show abstract

Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism

Cited by 18 publications

References 42 publications

Curcumin Compensates GLP‐1 Deficiency via the Microbiota‐Bile Acids Axis and Modulation in Functional Crosstalk between TGR5 and FXR in ob/ob Mice

Curcumin Compensates GLP‐1 Deficiency via the Microbiota‐Bile Acids Axis and Modulation in Functional Crosstalk between TGR5 and FXR in ob/ob Mice

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat Metabolic Disorders to Maintain Health

Contact Info

Product

Resources

About