Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo

Lee, Jae Won; Kim, Mun-Ock; Song, Yu Na; Min, Jeong Ki; Kim, Seong‐Man; Kang, Myung-Ji; Oh, Eun Sol; Lee, Ro Woon; Jung, Sunin; Ro, Hyunju; Lee, Jae Kyoung; Ryu, Hyung Won; Lee, Dong Hoon; Lee, Su Ui

doi:10.1016/j.jgr.2021.12.008

Cited by 14 publications

(12 citation statements)

References 60 publications

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“…S1 ) and demonstrated similar significance as compound K (ComK), a ginsenoside involved in regulation of airway inflammation and mucus secretion . For that reason, Rg5 presented a potential inhibitory effect on the hyperactivation of mucosa cells and thus was selected as the target compound for this study [ 34 ]. Furthermore, Rg5 reduced MUC5AC mRNA levels ( Fig.…”

Section: Resultsmentioning

confidence: 99%

A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells

Heo

Kim²,

Cha³

et al. 2023

Journal of Ginseng Research

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Section: Resultsmentioning

confidence: 99%

A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells

Heo

Kim²,

Cha³

et al. 2023

Journal of Ginseng Research

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“…FAGS and CK can be said to be substances that can compensate for the low in vivo metabolism and stability, which are shortcomings of antioxidants used in clinical asthma treatment. In addition, CK has been shown to exhibit anti-inflammatory and anti-asthmatic effects by inhibiting airway resistance, IgE plasma levels, airway inflammation, and mucus secretion in asthma mouse models [ 23 , 48 ]. These characteristics fully suggest the potential of CK as a therapeutic agent for asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Although the effects of all other ginsenosides have not been confirmed, CK in FAGS is considered sufficiently effective in asthma models. In a previous study, higher but quite low (4 μM) CK concentration than HFAGS showed an anti-inflammatory effect in an asthma model [ 48 ]. Further studies are needed to confirm the anti-asthmatic effect at the CK concentrations contained in LFAGS and HFAGS.…”

Section: Discussionmentioning

confidence: 99%

Fermented and Aged Ginseng Sprouts (Panax ginseng) and Their Main Component, Compound K, Alleviate Asthma Parameters in a Mouse Model of Allergic Asthma through Suppression of Inflammation, Apoptosis, ER Stress, and Ferroptosis

et al. 2022

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The association between asthma and oxidative stress remains controversial. Oxidative stress-induced ferroptosis has not been extensively studied in asthma models. This study was performed to investigate the anti-asthmatic and anti-ferroptotic effects of fermented and aged ginseng sprouts (FAGS) with enhanced antioxidant activity and its main component, compound K (CK), in a mouse model of ovalbumin (OVA)-induced allergic asthma. The experimental asthma model was sensitized and challenged with OVA. During the challenge period, two different concentrations of FAGS and CK were administered via oral gavage. Asthmatic parameters were analyzed in bronchoalveolar lavage fluid (BALF), blood, and lung tissue. CK, among the ginsenosides analyzed, was highly increased in FAGS compared with GS. Asthma parameters, such as Th2 cytokine and IgE production, mast cell activation, goblet cell hyperplasia, hyperresponsiveness, and inflammation, were dramatically increased in the OVA group. Oxidation and ferroptosis markers were increased in the OVA group. The asthma parameters and ferroptosis markers were markedly decreased in the OVA+FAGS and OVA+CK groups. These results showed that FAGS and CK alleviated asthma parameters in an allergic asthma mouse model by inhibiting inflammation and ferroptosis. Our findings suggest that FAGS and CK could be used as potential treatments for allergic asthma.

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“…The lung tissues were washed, fixed with 10% formalin, and finally embedded in paraffin. The paraffin-embedded lung tissues were then sectioned at a thickness of 4 μm using a rotary microtome and stained with H&E and PAS staining solution [ 63 , 64 ].…”

Section: Methodsmentioning

confidence: 99%

Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma

Park

Choi

Lee

et al. 2022

IJMS

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Methyl p-coumarate (methyl p-hydroxycinnamate) (MH) is a natural compound found in a variety of plants. In the present study, we evaluated the ameliorative effects of MH on airway inflammation in an experimental model of allergic asthma (AA). In this in vitro study, MH was found to exert anti-inflammatory activity on PMA-stimulated A549 airway epithelial cells by suppressing the secretion of IL-6, IL-8, MCP-1, and ICAM-1. In addition, MH exerted an inhibitory effect not only on NF-κB (p-NF-κB and p-IκB) and AP-1 (p-c-Fos and p-c-Jun) activation but also on A549 cell and EOL-1 cell (eosinophil cell lines) adhesion. In LPS-stimulated RAW264.7 macrophages, MH had an inhibitory effect on TNF-α, IL-1β, IL-6, and MCP-1. The results from in vivo study revealed that the increases in eosinophils/Th2 cytokines/MCP-1 in the bronchoalveolar lavage fluid (BALF) and IgE in the serum of OVA-induced mice with AA were effectively inhibited by MH administration. MH also exerted a reductive effect on the immune cell influx, mucus secretion, and iNOS/COX-2 expression in the lungs of mice with AA. The effects of MH were accompanied by the inactivation of NF-κB. Collectively, the findings of the present study indicated that MH attenuates airway inflammation in mice with AA, suggesting its potential as an adjuvant in asthma therapy.

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Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo

Cited by 14 publications

References 60 publications

A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells

A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells

Fermented and Aged Ginseng Sprouts (Panax ginseng) and Their Main Component, Compound K, Alleviate Asthma Parameters in a Mouse Model of Allergic Asthma through Suppression of Inflammation, Apoptosis, ER Stress, and Ferroptosis

Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma

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