Compound Fu brick tea modifies the intestinal microbiome composition in high‐fat diet‐induced obesity mice

Zhou, Caibi; Zhou, Xiaolu; Zhi-rui, Wen; Liu, Li Ming; Zhou, Yang; Yang, Lu; Li, Ping; Guo, Xiying; Mei, Xin

doi:10.1002/fsn3.1850

Cited by 17 publications

(9 citation statements)

References 42 publications

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“…Our study showed that RPT can reshape the gut flora disorder caused by CRD and increase the ratio of Bacteroidota / Firmicutes . Previous studies have shown that Firmicutes is more than Bacteroidota in the intestine, which leads to more effective absorption of food heat, thus resulting in obesity . In CR-W, the proportion of Firmicutes was increased which may be one of the reasons for obesity in mice.…”

Section: Discussionmentioning

confidence: 90%

“…Previous studies have shown that Firmicutes is more than Bacteroidota in the intestine, which leads to more effective absorption of food heat, thus resulting in obesity. 51 In CR-W, the proportion of Firmicutes was increased which may be one of the reasons for obesity in mice. RPT significantly reduced the abundance of the Lachnospiraceae NK4A136 group, E. fissicatena group, and Marvinbryantia.…”

Section: ■ Discussionmentioning

confidence: 99%

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Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model

Chen

Zhao

Sun

et al. 2021

J. Agric. Food Chem.

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Glucolipid metabolism, nitrogen metabolism, and inflammation are closely related to circadian rhythm disorder (CRD). Ripened Pu-erh tea (RPT) shows significant antidyslipidemic, antihyperurecemic, and anti-inflammatory effects. However, it is unclear whether healthy population are affected by CRD and whether long-term consumption of RPT can alleviate it. To investigate this problem, healthy mice were pretreated with RPT (0.25%, w/v) for 60 days and then subjected to CRD for 40 days. Our results indicated that healthy mice showed obesity, and the intestinal and liver inflammation increased after CRD, which were associated with the development of a metabolic disorder syndrome. RPT effectively reversed this trend by increasing the production and excretion rates of bile acid. RPT reshaped the disorder of gut microbiota caused by CRD and promoted the change of archaeal intestinal types from Firmicutes-dominant type to Bacteroidota-dominant type. In addition, by repairing the intestinal barrier function, RPT inhibited the infiltration of harmful microorganisms or metabolites through enterohepatic circulation, thus reducing the risk of chronic liver inflammation. In conclusion, RPT may reduce the risk of CRD-induced obesity in mice by increasing bile acid metabolism. The change of bile acid pool contributes to the reshaping of gut microflora, thus reducing intestinal inflammation and oxidative stress induced by CRD. Therefore, we speculated that the weakening of CRD damage caused by RPT is due to the improvement of bile acid-mediated enterohepatic circulation. It was found that 0.25% RPT (a human equivalent dose of 7 g/60 kg/ day) has potential for regulating CRD.

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Section: Discussionmentioning

confidence: 90%

Section: ■ Discussionmentioning

confidence: 99%

Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model

Chen

Zhao

Sun

et al. 2021

J. Agric. Food Chem.

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“…Notably, fat accumulation was reduced and the genes related to FFA uptake and β-oxidation significantly changed after dark tea treatment (16). Besides, dark tea enhanced the growth of bacteria in obese mice associated with healthy metabolic markers including Clostridiaceae, Bacteroidales, Lachnospiraceae, Akkermansia, Faecalibacterium prausnitzii, Lactobacilli, Actinobacteria, Muribaculaceae, Bacteroidaceae, and Prevotellaceae and reduced in harmful bacteria comprising Coriobacteriaceae, Streptococcaceae, Erysipelotrichaceae, Peptococcaceae, Peptostreptococcaceae, and Ruminococcaceae, and also the ratio of Firmicutes to Bacteroidetes (F/B) (18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 96%

Instant Dark Tea Alleviates Hyperlipidaemia in High-Fat Diet-Fed Rat: From Molecular Evidence to Redox Balance and Beyond

Qin

Yuanjie³

et al. 2022

Front. Nutr.

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Instant dark tea (IDT) is a new product gaining increasing attention because it is convenient and can endow significant health benefit to consumers, which is partially attributed to its high concentration of functional ingredients. However, the molecular mechanism underlying its regulatory effect on hyperlipidaemia is rarely studied. In this study, we performed omics and molecular verification in high-fat diet (HFD)-fed rat, aiming to reveal the mechanism and provide molecular evidence. The results showed that the major bioactive components in IDT were 237.9 mg/g total polysaccharides, 336.6 mg/g total polyphenols, and 46.9 mg/g EGCG. Rats fed with IDT (0.27–0.54 g/kg for 12 weeks) significantly reduced the body weight and TC, TG, LDL-C, blood glucose, and MDA and induced the level of serum HDL-C and also the levels of liver SOD, CAT, GSH-Px, and Nrf2, compared to HFD group. For molecular mechanism study, HIDT feeding had significant impact on the gene expressions of biomarkers in lipogenesis (FABP, CD36, SCD1, Cyp4a1, and Kcnn2), lipid oxidation (PPARγ), and glucose glycolysis (Gck and ENO2) in liver tissue. Moreover, gut microbiome study found that rats fed with IDT dramatically modified the gut microbial species at the family level, such as suppressing the increase abundance of Proteobacteria and Firmicutes induced by HFD. HIDT significantly boosted the relative composition of beneficial bacterium Akkermansia and Rikenellaceae_RC9_gut_group and decreased the relative abundance of the harmful bacterium Ruminococcaceae_UCG-005 and Ruminiclostridium_9, compared to HFD (p < 0.01). Correlation analysis between microbiome and animal indicators found that seven genera including Akkermansia, Clostridiales, Lachnospiraceae, Lachnospiraceae_UCG-010, Ruminiclostridium_9, Ruminococaceae-UCG-005, and Ruminocuccus_1 were found as potential biomarkers that were strongly correlated with oxidative stress and metabolism genes. For instance, Ruminococcaceae_UCG-005 was significantly correlated with body weight, TG, HDL-C, Nfr2, FABP3, SCD1, Cyp4a1, and Kcnn2. Collectively, the above data obtained in this study had provided the primary molecular evidence for the molecular mechanism and brought in novel insights based on omics for the regulatory effect of IDT on hyperlipidaemia.

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“…As a popular, economical, and safe drink, the effect of tea on obesity is widely understood, especially among overweight and obese individuals ( Wang et al, 2014 ; Ahmad et al, 2015 ; Xu et al, 2015 ; Chen et al, 2018b ). The potential mechanisms of tea on obesity are as follows: 1) reducing food intake and energy absorption ( Yang et al, 2016 ), 2) regulating the expression of lipid metabolism genes and inhibiting fat accumulation ( Chen et al, 2017 ), 3) enhancing the activity of antioxidant defense enzymes ( Ren et al, 2015 ; Chen et al, 2018a ), 4) regulating intestinal microflora disturbance and attenuating intestinal inflammation ( Li Y. et al, 2020 ; Zhou et al, 2020 ), and 5) maintaining intestinal barrier integrity ( Lu et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

A Mild Causal Relationship Between Tea Consumption and Obesity in General Population: A Two-Sample Mendelian Randomization Study

Niu

Guo

et al. 2022

Front. Genet.

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Evidence from observational studies for the effect of tea consumption on obesity is inconclusive. This study aimed to verify the causal association between tea consumption and obesity through a two-sample Mendelian randomization (MR) analysis in general population-based datasets. The genetic instruments, single nucleotide polymorphisms (SNPs) associated with tea consumption habits, were obtained from genome-wide association studies (GWAS): UK Biobank, Nurses’ Health Study, Health Professionals Follow-up Study, and Women’s Genome Health Study. The effect of the genetic instruments on obesity was analyzed using the UK Biobank dataset (among ∼500,000 participants). The causal relationship between tea consumption and obesity was analyzed by five methods of MR analyses: inverse variance weighted (IVW) method, MR-Egger regression method, weighted median estimator (WME), weighted mode, and simple mode. Ninety-one SNPs were identified as genetic instruments in our study. A mild causation was found by IVW (odds ratio [OR] = 0.998, 95% confidence interval [CI] = 0.996 to 1.000, p = 0.049]), which is commonly used in two-sample MR analysis, indicating that tea consumption has a statistically significant but medically weak effect on obesity control. However, the other four approaches did not show significance. Since there was no heterogeneity and pleiotropy in this study, the IVW approach has the priority of recommendation. Further studies are needed to clarify the effects of tea consumption on obesity-related health problems in detail.

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Compound Fu brick tea modifies the intestinal microbiome composition in high‐fat diet‐induced obesity mice

Cited by 17 publications

References 42 publications

Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model

Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model

Instant Dark Tea Alleviates Hyperlipidaemia in High-Fat Diet-Fed Rat: From Molecular Evidence to Redox Balance and Beyond

A Mild Causal Relationship Between Tea Consumption and Obesity in General Population: A Two-Sample Mendelian Randomization Study

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