“Compound blue nevus”: A reappraisal of “superficial blue nevus with prominent intraepidermal dendritic melanocytes” with emphasis on dermoscopic and histopathologic features

Ferrara, Gerardo; Argenziano, Giuseppe; Žgavec, Borut; Bartenjev, Igor; Staibano, Stefania; Rosa, Gaetano De; Soyer, H. Peter

doi:10.1067/mjd.2002.117858

Cited by 28 publications

(8 citation statements)

References 9 publications

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“…26 We also know that Ôcompound' blue (Kamino) nevi are often Ôblack-blue' nevi; in fact, they are recognizable on dermoscopy by the presence of a homogeneous bluish pigmentation with a central black lamella, the latter being histopathologically made up of pigmented parakeratosis overlying intraepidermal dendritic melanocytes. 16 Little is known about the dermoscopic-pathologic correlations in the many Ôvariations on the theme' of blue nevi shown in Table 1. In 1999, Bhawan and Cao 14 retrieved 38 amelanotic blue nevi over a series of 1358 blue nevi (2.8%) and they found that only three out of these 38 cases had been clinically recognized as blue nevi.…”

Section: Discussionmentioning

confidence: 99%

“…Cases of Ôcompound' blue nevus were not submitted to any of these measurements because of their definitional feature of pigmented dendritic melanocytes just within the epidermis. 16 Results Table 3 summarizes the clinicopathologic features of the 52 cases classified according to the histopathologic diagnosis and the dermoscopic features. The 52 lesions were removed from 19 men and 33 women ranging in age from 7 to 87 years (mean 44.7 years, median 43 years).…”

Section: Methodsmentioning

confidence: 99%

“…Atypical findings included large size, history of recent growth or change, inflammatory perilesional halo or dermoscopic features deviating from the stereotypical steel blue pigmentation. [23][24][25][26] The previously reported cases of Ôcompound' blue nevus 16 were also included in the study. Cases with incomplete clinical data and/or no preoperative dermoscopic documentation were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…The percentage of pigment decrease on histologic sections from hypo-amelanotic lesions ranged from 15 to 80% (mean 36%, median 30%); the percentage of fibrotic areas in sclerotic blue nevi ranged from 60 to 90% (mean 76.6%, median 80%). Histopathologic evaluation also included six combined blue nevi: common blue nevus with Spitz nevus (Ôblitz nevus'; 27 two cases), common blue nevus with dysplastic (Clark) nevus (one case), common blue nevus with congenital nevus (one case), Ôcompound' blue nevus with dysplastic (Clark) nevus (one case 16 ), and deep penetrating nevus with dermal nevus, Miescher type.…”

Section: Methodsmentioning

confidence: 99%

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The many faces of blue nevus: A clinicopathologic study

et al. 2006

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Background: In recent years, several histopathologic variants of blue nevus have been identified, whose clinical and dermoscopic correlates need further clarification. Methods: A comparative evaluation of histopathologic and dermoscopic features was carried out on 52 melanocytic proliferations belonging to the morphologic spectrum of blue nevus. Results: On dermoscopy, all lesions showed a homogeneous, structureless pigment pattern, with a curious variety of colors (blue, white-blue, black, brown, and polychromatic). Histopathologically, the majority of blue lesions were common blue nevi (11/19); the majority of white-blue lesions were Ôhypochromic' (sclerotic, hypomelanotic, and amelanotic) blue nevi (17/22); all the black lesions were Ôcompound' blue nevi (2/2); the majority of brown lesions were combined blue nevi (3/4); the unusual polychromatic dermoscopic appearance was often associated with a histopathologic diagnosis of deep penetrating nevus (2/5). Conclusion: A dermoscopic-pathologic approach now allows us to identify Ôblue' (common) blue nevi, Ôwhite' (hypochromic) blue nevi, Ôblack' (compound) blue nevi, Ôbrown' (combined) blue nevi, and Ôpolychromatic' (deep penetrating) blue nevi. A better recognition of the many dermoscopic faces of blue nevi is expected to give a morphologic guideline for the clinical management of these lesions. Ferrara G, Soyer HP, Malvehy J, Piccolo D, Puig S, Sopena J, Zalaudek I, Argenziano G. The many faces of blue nevus: A clinicopathologic study.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The many faces of blue nevus: A clinicopathologic study

et al. 2006

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“…Distinguishing a common blue nevus from a cellular blue nevus is a matter of degree of the cellular component of the lesion, and will be discussed below. The concept of a compound blue nevus has been proposed,30 31 but we have not observed convincing examples that could not be better accounted for as a deep penetrating nevus , a combined nevus (see below), or a blue nevus with overlying melanocytic hyperplasia.…”

Section: Spindle Cell Melanocytic Lesionsmentioning

confidence: 67%

Spindle cell melanocytic lesions: part II—an approach to intradermal proliferations and horizontally oriented lesions

2010

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Melanocytic lesions show great morphological diversity in their architecture and the cytomorphological appearance of their composite cells. Whereas functional melanocytes show a dendritic cytomorphology and territorial isolation, lesional nevomelanocytes and melanoma cells typically show epithelioid, spindled or mixed cytomorphologies, and a range of architectural arrangements. Spindling is common to melanocytic lesions, and may either be a characteristic feature or a divergent appearance. The presence of spindle cells may mask the melanocytic nature of a lesion, and is often disconcerting, either due to its infrequent appearance in a particular lesion or its interpretation as a dedifferentiated phenotype. Spindle cell melanocytic lesions follow the full spectrum of potential biological outcomes, and difficulty may be experienced judging the nature of a lesion due to a lack of consistently reliable features to predict biological behaviour. Over time, recognition of numerous histomorphological features that may portend a more aggressive lesion have been identified; however, the translation of these features into a diagnostic entity requires a gestalt approach. Although most spindle cell melanocytic lesions may reliably be resolved through this standard approach, problem areas do exist for the surgical pathologist or dermatopathologist. With this review (part II of II), we complete our discussion of spindle cell melanocytic lesions, in order to: (1) model a systematic approach to such lesions; and (2) provide familiarity with those melanocytic lesions which either typically or occasionally display a spindled cytomorphology.

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Disorders of the Cutaneous Melanocyte

Rm¹

2004

Rook's Textbook of Dermatology

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“Compound blue nevus”: A reappraisal of “superficial blue nevus with prominent intraepidermal dendritic melanocytes” with emphasis on dermoscopic and histopathologic features

Cited by 28 publications

References 9 publications

The many faces of blue nevus: A clinicopathologic study

The many faces of blue nevus: A clinicopathologic study

Spindle cell melanocytic lesions: part II—an approach to intradermal proliferations and horizontally oriented lesions

Disorders of the Cutaneous Melanocyte

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