Compound Bacillus alleviates diarrhea by regulating gut microbes, metabolites, and inflammatory responses in pet cats

Wang, Fei; Mei, Xiaoying; Wang, Qi; Zhao, Pengwei; Zhou, Yuanhao; Tang, Li; Wang, Baikui; Xu, Shujie; Li, Xiang; Jin, Qian; Xiao, Yingping; Li, Weifen

doi:10.1186/s42523-023-00270-8

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…Lee et al [ 13 ] found that Bacillus licheniformis fermentation products, previously used as additives in poultry and pig feed, improved fecal consistency in a few cats and significantly increased the numbers of Blautia spp., Ruminococcus torques , and Ruminococcus gnavus in feces. Wang et al [ 14 ] discovered that probiotics ( Bacillus amyloliquefaciens SC06 and Bacillus subtilis B10) significantly reduced the incidences of soft stools and diarrhea in pet cats, markedly increased the numbers of Patescibacter and Plectosphaerella in cat feces, and decreased the abundances of Firmicutes , Gemmatimonadetes , Ruminococcaceae , Ascochytahe , and Saccharomyces . The probiotic SLAB51™, comprising several Lactobacilli , Bifidobacteria, and Streptococcus species, significantly increased the numbers of Lactobacillus spp.…”

Section: Probiotics and General Intestinal Healthmentioning

confidence: 99%

Probiotics and Cat Health: A Review of Progress and Prospects

Zha,

Zhu,

Chen

2024

Microorganisms

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Cats are increasingly favored as companion animals; their health has drawn widespread attention. Given the continuous improvements in the required living standards of both humans and animals, inflammatory bowel disease, allergies, diarrhea, constipation, periodontal disease, obesity, diabetes, and other health issues have become recognized as valid pet problems. Antibiotics are commonly used to treat pet diseases, greatly improving animal health. However, antibiotic abuse is common, especially when seeking to treat bacterial infections. Probiotics are beneficial microorganisms that may be directly ingested in food or as feed additives; they improve the intestinal microflora balance, enhance immunity, and ensure healthy growth. However, cat data are usually inferred from reports on dogs or humans; cat research remains preliminary in nature. Therefore, we here describe the current understanding of how probiotics improve cat health, facilitating the further development and application of probiotics for cats.

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Section: Probiotics and General Intestinal Healthmentioning

confidence: 99%

Probiotics and Cat Health: A Review of Progress and Prospects

Zha,

Zhu,

Chen

2024

Microorganisms

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Effects of dietary fiber and biotic supplementation on apparent total tract macronutrient digestibility and the fecal characteristics, metabolites, and microbiota of healthy adult dogs

Wilson,

Kang,

Marshall

et al. 2024

Journal of Animal Science

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Dietary fibers and biotics have been shown to support gastrointestinal health in dogs, but are usually tested individually. There is value in testing fiber-biotic combinations that are commonly used commercially. Therefore, this study was conducted to determine the apparent total tract macronutrient digestibility (ATTD) of diets supplemented with fibers or biotics and to evaluate their effects on the fecal characteristics, metabolites, microbiota, and immunoglobulin A (IgA) concentrations of dogs. Twelve healthy adult female beagle dogs (age= 6.2 ± 1.6 yr; body weight = 9.5 ± 1.1 kg) were used in a replicated 3 x 3 Latin square design to test three treatments: 1) control diet based on rice, chicken meal, tapioca starch, and cellulose + a placebo treat (CT); 2) diet based on rice, chicken meal, garbanzo beans, and cellulose + a placebo treat (GB); 3) diet based on rice, chicken meal, garbanzo beans, and a functional fiber/prebiotic blend + a probiotic-containing treat (GBPP). In each 28-day period, a 22-day diet adaptation was followed by a 5-day fecal collection phase. Fasted blood samples were collected on day 28. Data were analyzed using the Mixed Models procedure of SAS 9.4, with P<0.05 being significant and P<0.10 being trends. ATTD of dry matter, organic matter, and energy were lower (P<0.001) and DM fecal output was higher (P<0.01) in dogs fed GBPP than CT or GB, whereas ATTD of crude protein was higher (P<0.001) in dogs fed CT and GBPP than GB. ATTD of fat was higher (P<0.001) and wet fecal output was lower (P<0.01) in dogs fed CT than GB or GBPP. Fecal DM% was higher (P<0.001) in dogs fed CT than GBPP or GB, and higher in dogs fed GBPP than GB. Fecal short-chain fatty acid concentrations were higher (P<0.001) in dogs fed GB than CT or GBPP, and higher in dogs fed GB than GBPP. Fecal IgA concentrations were higher (P<0.01) in dogs fed GB than CT. Fecal microbiota populations were affected by diet, with alpha diversity being higher (P<0.01) in dogs fed GB than CT, and beta diversity shifting following dietary fiber and biotic supplementation. The relative abundance of 24 bacterial genera were altered in dogs fed GB or GBPP than CT. Serum triglyceride concentrations were lower in dogs fed GB than GBPP or CT. Our results demonstrate that legume-based dietary fibers, with or without prebiotics and probiotics, reduce ATTD, increase stool output, beneficially shift fecal metabolites and microbiota, and reduce blood lipids of adult dogs.

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Compound Bacillus alleviates diarrhea by regulating gut microbes, metabolites, and inflammatory responses in pet cats

Cited by 2 publications

References 52 publications

Probiotics and Cat Health: A Review of Progress and Prospects

Probiotics and Cat Health: A Review of Progress and Prospects

Effects of dietary fiber and biotic supplementation on apparent total tract macronutrient digestibility and the fecal characteristics, metabolites, and microbiota of healthy adult dogs

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