Compositions and <i>in vitro</i> Anticancer activities of the Leaf and Fruit Oils of <i>Litsea cubeba</i> from Taiwan

Ho, Chyi-Chen; Jie-Pinge, Ou; Liu, Yao–Chi; Hung, Chien-Ping; Tsai, Ming-Chih; Liao, Pei‐Chun; Wang, Eugene I-Chen; Chen, Yilin; Su, Yu-Chang

doi:10.1177/1934578x1000500425

Cited by 40 publications

(48 citation statements)

References 14 publications

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“…The chemical composition of essential oils of L. cubeba varies according to habitat and tissue Ho et al 2010). The three enzyme products obtained from the mono-TPS of L. cubeba have previously been reported to be the components of the essential oils from different parts of L. cubeba (Lagalante and Montgomerys 2003;Marriacci et al 1994).…”

Section: Different Expression Patterns Of Lctps In Varies Tissuesmentioning

confidence: 98%

“…Previous studies have shown that the essential oils of L. cubeba dispel rheumatism, detoxify, and have an analgetic effect, and the extracts from different tissues also showed remarkable antioxidant activity in comparison with α-tocopherol and ascorbic acid (Hwang et al 2005). The dominant components in the essential oils of L. cubeba are monoterpenes (Ho et al 2010). In this article, we report the isolation and functional characterization of three monoterpene synthase (mono-TPS) genes from L. cubeba: LcTPS1, LcTPS2, and LcTPS3.…”

Section: Introductionmentioning

confidence: 98%

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Molecular cloning and characterization of monoterpene synthases from Litsea cubeba (Lour.) Persoon

Chang

Chu

2011

Tree Genetics & Genomes

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Mountain pepper (Litsea cubeba (Lour.) Persoon) is an evergreen tree in the Lauraceae family and has attracted attention for the antioxidant and antibacterial effects of its essential oils. The dominant components of the essential oil of L. cubeba are monoterpenes. To investigate the biosynthesis of monoterpenes that have bioactivity in L. cubeba, three cDNAs corresponding to monoterpene synthase genes were isolated, and the corresponding enzymes were functionally characterized in vitro. The genes obtained were named LcTPS1, LcTPS2, and LcTPS3. Transcript levels for LcTPS1 were most prominent in the leaf tissues, and levels of LcTPS2 and LcTPS3 were more evident in fruit tissues than in leaf tissues. Phylogenetic analyses indicated that LcTPS1, LcTPS2, and LcTPS3 all belong to TPS-b subfamily of angiosperm monoterpene synthases. For each genes, the corresponding enzymes were expressed and functionally characterized. LcTPS1 converted geranyl diphosphate to trans-ocimene, and LcTPS2 converted geranyl diphosphate to α-thujene, while LcTPS3 is a mutifunctional enzyme that converted geranyl diphosphate to α-thujene and (+)-sabinene, respectively.

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Section: Different Expression Patterns Of Lctps In Varies Tissuesmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Molecular cloning and characterization of monoterpene synthases from Litsea cubeba (Lour.) Persoon

Chang

Chu

2011

Tree Genetics & Genomes

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“…Cytotoxicity against tumor cell lines of its extracts, epigenetic modifications of cancer oncogenes, and tumor suppressor genes were described. It was also reported that Radix Angelicae sinensis may be a potential source of glutathione S-transferase inhibitors and counteract multidrug resistance [26–30]. One report described antiproliferative activity of Gentiana triflora root extract on cultured and implanted tumor cells [29].…”

Section: Introductionmentioning

confidence: 99%

“…One report described antiproliferative activity of Gentiana triflora root extract on cultured and implanted tumor cells [29]. Fruit oils of Litsea cubeba from Taiwan exhibited cytotoxic activity against human lung, liver, and oral cancer cells in vitro [30, 31]. Galangin, flavonol present in Alpinia galanga rhizome, induced apoptosis of cancer cells [32, 33].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice

Skopiński

Bałan

Kocik

et al. 2013

Mediators of Inflammation

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Anticancer activity of many herbs was observed for hundreds of years. They act as modifiers of biologic response, and their effectiveness may be increased by combining multiple herbal extracts . PERVIVO, traditional digestive herbal remedy, contains some of them, and we previously described its antiangiogenic activity. Numerous studies documented anticancer effects of nonsteroidal anti-inflammatory drugs. We were the first to show that sulindac and its metabolites inhibit angiogenesis. In the present paper the combined in vivo effect of multicomponent herbal remedy PERVIVO and nonsteroidal anti-inflammatory drug sulindac on tumor growth, tumor angiogenesis, and tumor volume in Balb/c mice was studied. These effects were checked after grafting cells collected from syngeneic sarcoma L-1 tumors into mice skin. The strongest inhibitory effect was observed in experimental groups treated with PERVIVO and sulindac together. The results of our investigation showed that combined effect of examined drugs may be the best way to get the strongest antiangiogenic and antitumor effect.

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“…All parts of this plant emanate a pungent gingery odor [10]. Fruits of L. cubeba are spicy condiments, frequently used in the aboriginal cuisine of Taiwan [11].…”

Section: Introductionmentioning

confidence: 99%

Immunosuppressive Effect of Litsea cubeba L. Essential Oil on Dendritic Cell and Contact Hypersensitivity Responses

Chen

Chang

Hseu

et al. 2016

IJMS

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Litsea cubeba L., also named as Makauy, is a traditional herb and has been used as cooking condiment or tea brewing to treat diseases for aborigines. The present study was undertaken to explore the chemical compositions of the fruit essential oil of L. cubeba (LCEO) and the immunomodulatory effect of LCEO on dendritic cells and mice. The LCEO was analyzed using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) with direct injection (DI/GC) or headspace-solid phase microextraction (HS-SPME/GC). In total, 56 components were identified, of which 48 were detected by DI/GC and 49 were detected by HS-SPME/GC. The principal compounds were citral (neral and geranial). An immunosuppressive activity of LCEO was investigated with bone marrow-derived dendritic cells (DCs) which have a critical role to trigger the adaptive immunity. Additionally, the inhibitory effect of LCEO on immune response was elucidated by performing the contact hypersensitivity (CHS) responses in mice. Our results clearly showed that LCEO decreases the production of TNF-α and cytokine IL-12 in a dose-dependent manner in lipopolysaccharide (LPS)-stimulated DCs. CHS response and the infiltrative T cells were inhibited in the tested ears of the mice co-treated with LCEO. We demonstrate, for the first time, that the LCEO mainly containing citral exhibits an immunosuppressive effect on DCs and mice, indicating that LCEO can potentially be applied in the treatment of CHS, inflammatory diseases, and autoimmune diseases.

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Compositions and in vitro Anticancer activities of the Leaf and Fruit Oils of Litsea cubeba from Taiwan

Cited by 40 publications

References 14 publications

Molecular cloning and characterization of monoterpene synthases from Litsea cubeba (Lour.) Persoon

Molecular cloning and characterization of monoterpene synthases from Litsea cubeba (Lour.) Persoon

Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice

Immunosuppressive Effect of Litsea cubeba L. Essential Oil on Dendritic Cell and Contact Hypersensitivity Responses

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