Compositional Safety of Herbicide-Tolerant DAS-81910-7 Cotton

Herman, Rod A.; Fast, Brandon J.; Johnson, Tempest Y.; Sabbatini, Jane; Rudgers, Gary W.

doi:10.1021/jf404043y

Cited by 11 publications

(12 citation statements)

References 18 publications

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“…This avoided confounding any possible effects of transgenesis or stacking GM events with any possible effects of the trait‐associated herbicides, and because the use of herbicides on nonGM crop plants has a history of safe use. The application of herbicides to crops has never been associated with any adverse compositional change in a crop, and there is no reasonable hypothesis for why GM crops would respond differently to trait‐related herbicides (Herman and Price, ; Herman et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Stacking transgenic event DAS‐Ø15Ø7‐1 alters maize composition less than traditional breeding

Herman¹,

Fast²,

Scherer³

et al. 2017

Plant Biotechnology Journal

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SummaryThe impact of crossing (‘stacking’) genetically modified (GM) events on maize‐grain biochemical composition was compared with the impact of generating nonGM hybrids. The compositional similarity of seven GM stacks containing event DAS‐Ø15Ø7‐1, and their matched nonGM near‐isogenic hybrids (iso‐hybrids) was compared with the compositional similarity of concurrently grown nonGM hybrids and these same iso‐hybrids. Scatter plots were used to visualize comparisons among hybrids and a coefficient of identity (per cent of variation explained by line of identity) was calculated to quantify the relationships within analyte profiles. The composition of GM breeding stacks was more similar to the composition of iso‐hybrids than was the composition of nonGM hybrids. NonGM breeding more strongly influenced crop composition than did transgenesis or stacking of GM events. These findings call into question the value of uniquely requiring composition studies for GM crops, especially for breeding stacks composed of GM events previously found to be compositionally normal.

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Section: Resultsmentioning

confidence: 97%

Stacking transgenic event DAS‐Ø15Ø7‐1 alters maize composition less than traditional breeding

Herman¹,

Fast²,

Scherer³

et al. 2017

Plant Biotechnology Journal

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“…A literature search on GMO safety evaluation revealed a consensus that the EL for the GMO mean could be based on the marginal distribution of references across sites (e.g. Berman et al 2010; Zhou et al 2011; Herman et al 2013; Lepping et al 2013; Lundry et al 2013; Privalle et al 2013; Brink et al 2014; Venkatesh et al 2014). Under Model (2), the marginal reference distribution has a variance of .…”

Section: Methodsmentioning

confidence: 99%

“…Until recently, this has been accomplished via statistically comparing the GMO with its near-isogenic non-GM counterpart for each endpoint under the null hypothesis of ‘no difference’. A partial list of literature that executes such an assessment includes (Berman et al 2010; Zhou et al 2011; Herman et al 2013; Lepping et al 2013; Lundry et al 2013; Privalle et al 2013; Brink et al 2014; Venkatesh et al 2014). Non-significance is taken to mean there is no consequential difference between the two crops for a given endpoint.…”

Section: Introductionmentioning

confidence: 99%

Equivalence criteria for the safety evaluation of a genetically modified crop: a statistical perspective

Vahl

Kang²

2015

J. Agric. Sci.

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SUMMARYSafety evaluation of a genetically modified (GM) crop is accomplished by establishing its substantial equivalence to non-GM reference crops with a history of safe use. Testing hypotheses of equivalence rather than difference is the appropriate statistical approach. A necessary first step in this regard is to specify a reasonable equivalence criterion that includes a measure for discrepancy between the GM and reference crops as well as a regulatory threshold. The present work explored several equivalence criteria and discussed their pros and cons. Each criterion addresses one of three ordered classes of equivalence: super, conditional and marginal equivalence. Their implications were investigated over an array of parameter values estimated from a real-world dataset. Marginal equivalence was identified as adhering most closely to the concept of substantial equivalence. Because conditional equivalence logically implies marginal equivalence and is practically quantifiable from current field designs, the present work recommends conditional equivalence criteria while encouraging producers to improve their design to enable testing marginal equivalence in the future. Contrary to concerns of the ag-biotech industry, empirical evidence from recent publications indicates that a linear mixed model currently implemented by the European Food Safety Authority is adequate for assessing equivalence despite its lack of genotype-by-environment interaction terms.

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“…As substantial equivalence is the concept that is most widely adopted and used to evaluate the biosafety of GM crops, compositional safety has been investigated by comparing transgenic crops like soybean, pepper, cotton, and corn with non-transgenic counterparts (Ridley et al, 2002 ; Park et al, 2006 ; McCann et al, 2007 ; Rui et al, 2009 ; Herman et al, 2010 , 2011 , 2013 ; Mohanta et al, 2011 ; Costa et al, 2015 ). Most of these studies draw a similar conclusion that there were no statistical differences between GM plants and their controls.…”

Section: Transgenes and Their Impact On Mineralsmentioning

confidence: 99%

Prospecting for Microelement Function and Biosafety Assessment of Transgenic Cereal Plants

Luo

Huang

et al. 2018

Front. Plant Sci.

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Microelement contents and metabolism are vitally important for cereal plant growth and development as well as end-use properties. While minerals phytotoxicity harms plants, microelement deficiency also affects human health. Genetic engineering provides a promising way to solve these problems. As plants vary in abilities to uptake, transport, and accumulate minerals, and the key enzymes acting on that process is primarily presented in this review. Subsequently, microelement function and biosafety assessment of transgenic cereal plants have become a key issue to be addressed. Progress in genetic engineering of cereal plants has been made with the introduction of quality, high-yield, and resistant genes since the first transgenic rice, corn, and wheat were born in 1988, 1990, and 1992, respectively. As the biosafety issue of transgenic cereal plants has now risen to be a top concern, many studies on transgenic biosafety have been carried out. Transgenic cereal biosafety issues mainly include two subjects, environmental friendliness and end-use safety. Different levels of gene confirmation, genomics, proteomics, metabolomics and nutritiomics, absorption, metabolism, and function have been investigated. Also, the different levels of microelement contents have been measured in transgenic plants. Based on the motivation of the requested biosafety, systematic designs, and analysis of transgenic cereal are also presented in this review paper.

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Compositional Safety of Herbicide-Tolerant DAS-81910-7 Cotton

Cited by 11 publications

References 18 publications

Stacking transgenic event DAS‐Ø15Ø7‐1 alters maize composition less than traditional breeding

Stacking transgenic event DAS‐Ø15Ø7‐1 alters maize composition less than traditional breeding

Equivalence criteria for the safety evaluation of a genetically modified crop: a statistical perspective

Prospecting for Microelement Function and Biosafety Assessment of Transgenic Cereal Plants

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