The importance of integrating and coordinating supply chain business partners have been appreciated in many industries. In the global manufacturing industry, supply chain business partners' information integration is technically a daunting task due to highly disconnected infrastructures and operations. Information, software applications, and services are loosely distributed among participant business partners with heterogeneous operating infrastructures. A secure, and flexible information exchange architecture that can interconnect distributed information and share that information across global service provision applications is, therefore, immensely advantageous. This chapter describes the main features of an ontology-based web service framework for integrating distributed business processes in a global supply chain. A Scalable Web Service Discovery Framework (SWSDF) for material procurement systems of a manufacturing supply chain is described. Description Logic (DL) is used to represent and explain SWSDF. The framework uses a hybrid knowledge-based system, which consists of Case-Based Reasoning (CBR) and Rule-Based Reasoning (RBR). SWSDF includes: (1) a collection of web service descriptions in Ontology Web Language-Based Service (OWL-S), (2) service advertisement using complex concepts, and (3) a service concept similarity assessment algorithm. Finally, a business scenario is used to demonstrate functionalities of the described system.