Compositional dependence of the apatite formation ability of Ti–Zr alloys designed for hard tissue reconstruction

Miyazaki, Toshiki; Hosokawa, Tomoya; Yokoyama, K.; Shiraishi, Takashi

doi:10.1007/s10856-020-06448-9

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…The present results would be related to amount of surface functional group. We reported that amount of Ti-OH and Zr-OH groups in NaOH-treated Ti-50Zr was 75% of NaOH-treated Ti 5) . The adhesion of the apatite layer is also governed by the amount of the surface functional group.…”

Section: Discussionmentioning

confidence: 91%

“…Treatments of alloys based on NaOH and heating have been used to modify the surface of Ti-50Zr alloys. Such treatments may allow for partial apatite formation on the Ti-50Zr alloy surface after 7 days in a simulated body fluid (SBF), which has inorganic ion composition similar to that of extracellular fluid 4,5) . Ti-OH and Zr-OH groups formed on the alloy by the surface treatments are considered to trigger the heterogeneous apatite nucleation by a catalytic effect 3) .…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of apatite formation on Ti-50Zr alloy in simulated body environment

2023

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Ti-50Zr alloy is 2.5 times as strong as pure Ti and has a lower Young's modulus, making it a useful material for repairing bone and teeth. However, Ti-50Zr alloy has a limited ability to bond with bone in vivo. Under biological conditions, apatite formation at the surface of a Ti or alloy implant is necessary for its bonding with bone. Various approaches to surface modification have been proposed to impart bone-bonding ability to Ti-50Zr alloy; however, there remains a need for further improvements to the alloy's apatiteforming ability. Hence, in this study, we compared apatite formation at the surface of alloy substrates in simulated body fluid, after various surface treatments. Treatment with 5 M NaOH followed by 1 M CaCl2 was the most effective procedure, whereas a sample subjected to a hot water post-treatment formed less apatite. Notably, no apatite formed on samples treated with 10 M NaOH.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Enhancement of apatite formation on Ti-50Zr alloy in simulated body environment

2023

Self Cite

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“…In alkali-heating treatment [ 5 , 28 ], even after 7 d of SBF soaking, the apatite cannot cover the Zr-50Ti alloy completely. Additionally, the formed apatite was uneven and similar to those in group CaP, which were gigantic ball-like aggregates.…”

Section: Discussionmentioning

confidence: 99%

“…Their elastic modulus is close to that of Zr-40Ti, the lowest among Zr-Ti binary alloys. The apatite-forming ability of Zr-Ti alloys significantly decreases when the Zr content exceeds 60 atom% [ 5 ]. These properties suggest that Zr-50Ti alloys could be a promising biomaterial.…”

Section: Introductionmentioning

confidence: 99%

Development of Rapid Bioactivity-Expressed Zr-50Ti Alloys by Surface Treatment with Modified Simulated Body Fluid

Wu,

Takai,

Yabutsuka

2024

IJMS

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Zr-50Ti alloys are promising biomaterials due to their excellent mechanical properties and low magnetic susceptibility. However, Zr-50Ti alloys do not inherently bond well with bone. This study aims to enhance the bioactivity and bonding strength of Zr-50Ti alloys for orthopedic implant materials. Initially, the surface of Zr-50Ti alloys was treated with a sulfuric acid solution to create a microporous structure, increasing surface roughness and area. Subsequently, low crystalline calcium phosphate (L-CaP) precipitation was controlled by adding Mg2+ and/or CO32− ions in modified simulated body fluid (m-SBF). The treated Zr-50Ti alloys were then subjected to cold isostatic pressing to force m-SBF into the micropores, followed by incubation to allow L-CaP formation. The apatite-forming process was tested in simulated body fluid (SBF). The results demonstrated that the incorporation of Mg2+ and/or CO32− ions enabled the L-CaP to cover the entire surface of Zr-50Ti alloys within only one day. After short-term soaking in SBF, the L-CaP layer, modulated by Mg2+ and/or CO32− ions, formed a uniform hydroxyapatite (HA) coating on the surface of the Zr-50Ti alloys, showing potential for optimized bone integration. After soaking in SBF for 14 days, the bonding strength between the apatite layer and alloy has the potential to meet the orthopedic application requirement of 22 MPa. This study demonstrates an effective method to enhance the bioactivity and bonding strength of Zr-50Ti alloys for orthopedic applications.

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Apatite Formation on α-Tricalcium Phosphate Modified with Bioresponsive Ceramics in Simulated Body Fluid Containing Alkaline Phosphatase

Yokoi,

Tomita,

Nakamura

et al. 2024

Biomimetics

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Bioresponsive ceramics, a new concept in ceramic biomaterials, respond to biological molecules or environments, as exemplified by salts composed of calcium ions and phosphate esters (SCPEs). SCPEs have been shown to form apatite in simulated body fluid (SBF) containing alkaline phosphatase (ALP). Thus, surface modification with SCPEs is expected to improve the apatite-forming ability of a material. In this study, we modified the surface of α-tricalcium phosphate (α-TCP) using methyl, butyl, or dodecyl phosphate to form SCPEs and investigated their apatite formation in SBF and SBF containing ALP. Although apatite did not form on the surface of the unmodified α-TCP in SBF, apatite formation was observed following surface modification with methyl or butyl phosphate. When ALP was present in SBF, apatite formation was especially remarkable on α-TCP modified with butyl phosphate. These SCPEs accelerated apatite formation by releasing calcium ions through dissolution and supplying inorganic phosphate ions, with the latter process only occurring in SBF containing ALP. Notably, no apatite formation occurred on α-TCP modified with dodecyl phosphate, likely because of the low solubility of the resulting calcium dodecyl phosphate/calcium phosphate composites. This new method of using SCPEs is anticipated to contribute to the development of novel ceramic biomaterials.

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Compositional dependence of the apatite formation ability of Ti–Zr alloys designed for hard tissue reconstruction

Cited by 3 publications

References 32 publications

Enhancement of apatite formation on Ti-50Zr alloy in simulated body environment

Enhancement of apatite formation on Ti-50Zr alloy in simulated body environment

Development of Rapid Bioactivity-Expressed Zr-50Ti Alloys by Surface Treatment with Modified Simulated Body Fluid

Apatite Formation on α-Tricalcium Phosphate Modified with Bioresponsive Ceramics in Simulated Body Fluid Containing Alkaline Phosphatase

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