Compositional Data Analysis with PLS-DA and Security Applications

Ankam, Divya; Bouguila, Nizar

doi:10.1109/iri.2018.00058

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…PLS-DA is a statistical method that creates a linear regression model to find the relationships between the variables (lipid mediators) and observation's classes (treatment, time points etc.) (Ballabio and Consonni, 2013;Worley et al, 2013;Kalivodova et al, 2015;Ankam and Bouguila, 2018). As shown in the score plot (Fig.…”

Section: Multivariate Data Analyses Of Regulatory Lipid Mediator Profmentioning

confidence: 83%

Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets

Yang

Bruun

Wang

et al. 2019

Toxicology and Applied Pharmacology

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Organophosphates (OPs), a class of phosphorus-containing chemicals that act by disrupting cholinergic transmission, include both toxic and fast-acting chemical warfare agents as well as less toxic but more easily accessible OP pesticides. The classical atropine/2-PAM antidote fails to protect against long-term symptoms following acute intoxication with OPs at levels that trigger status epilepticus. Acute OP intoxication also causes a robust neuroinflammatory response, which is implicated in the pathogenesis of long-term effects. In this study, we characterized the profiles of lipid mediators, important players in neuroinflammation, in the rat model of acute DFP intoxication. The profiles of lipid mediators were monitored in three different regions of the brain (cortex, hippocampus, and cerebellum) at 0, 1, 3, 7, 14, and 28 days post-exposure. The distribution pattern of lipid mediators was distinct in the three brain regions. In the cerebellum, the profile is dominated by LOX metabolites, while the lipid mediator profiles in cortex and hippocampus are dominated by COX metabolites followed by LOX and CYP 450 metabolites. Following acute DFP intoxication, most of the pro-inflammatory lipid mediators (e.g., PGD2 and PGE2) increased rapidly from day 1, while the concentrations of some anti-inflammatory lipid mediators (e.g. 14,15 EpETrE) decreased after DFP intoxication but recovered by day 14 postexposure. The lipidomics results suggest two potential treatment targets: blocking the formation of prostaglandins by inhibiting COX and stabilizing the anti-inflammatory lipid mediators containing epoxides by inhibiting the enzyme soluble epoxide hydrolase (sEH).

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Section: Multivariate Data Analyses Of Regulatory Lipid Mediator Profmentioning

confidence: 83%