Compositional and temporal changes of the gut microbiome in women with cervical cancer undergoing chemoradiation: Does it predict response?

The Lactobacillus Crispatus M247 oral administration: it really is an effective strategy in the management of papillomavirus-infected women?

“…Patients with cervical cancer shown a higher gut microbiota diversity, although this difference was not statistically signi cant [17].Actually, in a grander examination of the gut microbiome in cervical cancer patients versus women without cervical cancer, our group observed a statistically signi cant higher a-diversity in cervical cancer patients than in healthy controls [18].Moreover, literature reported signi cant differences in several taxa between cervical cancer patients and controls, predominantly that members of the phylum Proteobacteria were superior in cervical cancer women [19]Different studies reported a distinction in taxonomic abundance pro les between cervical cancer patients and the control group [18].The intestinal microbiome is deeply conditioned by diet, as well as by individual factors. Therefore, Sims et al concludes that since cervical HPV-lesion are associated with vaginal and gut microbiota [20]. Oral probiotic treatment could modulate both intestinal and vaginal microbioma reducing HPV lesions [20].…”

“…Therefore, Sims et al concludes that since cervical HPV-lesion are associated with vaginal and gut microbiota [20]. Oral probiotic treatment could modulate both intestinal and vaginal microbioma reducing HPV lesions [20]. So, the use of Lactobacillus Crispatus orally allows to obtain a colonization in the intestine that in a few days allows the transfer of lactobacillus into the vagina.…”