Composition, Structure, and Formation of Biofilms Constituted by Periodontopathogenic Microorganisms

Carmello, Juliana Cabrini; Annunzio, Sarah Raquel de; Fontana, Carla Raquel

doi:10.5772/intechopen.90019

Cited by 2 publications

(1 citation statement)

References 79 publications

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“…Channels in the biofilm allow getting water, air, and nutrients to all parts of this structure [13]. Particular layers of microorganisms in biofilms bind to existing bacteria through coaggregation [14].…”

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

et al. 2021

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In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological response of the host, and accumulation of various bioactive compounds (enzymes and others) affecting host physiology and changing local pH values, which further influence various biological functions. In this review article, we provide an overview on the formation of bacterial biofilm and its properties, and then we focus on the possible use of phage-derived depolymerases to combat bacterial cells included in this complex structure. On the basis of the literature review, we conclude that, although these bacteriophage-encoded enzymes may be effective in destroying specific compounds involved in the formation of biofilm, they are rarely sufficient to eradicate all bacterial cells. Nevertheless, a combined therapy, employing depolymerases together with antibiotics and/or other antibacterial agents or factors, may provide an effective approach to treat infections caused by bacteria able to form biofilms.

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Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

et al. 2021

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Pocket reduction with High Concentrated oxygen oral gel: A Preliminary Case Report

Asha

Mlv

Rashmi

et al. 2022

RJPT

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Introduction: Oxygen is a prerequisite for successful wound healing due to the increased demand for reparative processes such as cell proliferation, bacterial defense, angiogenesis and collagen synthesis. Even though the role of oxygen in wound healing is not fully ascertained many experimental investigations and clinical observations have shown wound healing to be impaired under hypoxia. Since the periodontal pocket harbours anaerobic microorganisms a high concentrated oxygen formulation could prove to be a lethal elimination tool. Objective: The main objective of this study was to evaluate efficacy of high concentrated oxygen oral gel on the reduction of periodontal pocket. Materials and methods: A female patient of age 28 years without any systemic complication or allergic reaction reporting to Outpatient department of Krishnadevaraya College of Dental Sciences was examined. After ascertaining the presence of periodontal pocket (≥ 5mm) without infrabony defects, she was enlisted for the study. Following scaling and root planing and oral hygiene reinforcement, daily application of (Blue®M) TM oral gel for 7 days into the pocket was carried out, re-evaluation of the pocket depth was done after 30 days. Conclusion: High concentrated oxygen (Blue®M)TM oral gel could be locally delivering drug in reduction of periodontal pocket.

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Composition, Structure, and Formation of Biofilms Constituted by Periodontopathogenic Microorganisms

Cited by 2 publications

References 79 publications

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

Pocket reduction with High Concentrated oxygen oral gel: A Preliminary Case Report

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