Composition of the essential oil of Artemisia ciniformis, A. kopetdaghensis, and A. khorasanica in Iran

Firouzni, Ali; Vahedi, Homayoon; Sabbaghi, Farahnaz; Bigdeli, Mohsen

doi:10.1007/s10600-009-9212-6

Cited by 14 publications

(6 citation statements)

References 14 publications

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“…ex Poljak, which were collected from the Bojnourd area of Iran in November 2005, consisted of ten monoterpene hydrocarbons (35.5%), seven oxygenated monoterpenes (23.1%), and four sesquiterpenes (33.9%). Davanone (29.6%), myrcene (14.4%), camphor (10.6%), p-cymene (9.6%) and linalool (8.6%) were found to be the major components among the 22 constituents characterized, comprising 92.5% of the total components detected ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Chemical Constituents and In Vitro Anticancer, Cytotoxic, Mutagenic and Antimutagenic Activities of Artemisia Diffusa

Taherkhani

2015

Pharm Chem J

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The aim of this study was to determine the chemical constituents, antimicrobial, cytotoxicity, mutagenic and anti-mutagenic activities of the essential oil of Artemisia ciniformis Krasch. & Popov ex Poljakov, against important bacterial pathogens and human cells which were unknown before. In-vitro cytotoxicity was measured using a modified MTT assay on normal human lymphocytes and tumor HeLa cells. The mutagenic and antimutagenic activities of the oil were evaluated using the Salmonella typhimurium tester strains TA98 and TA100, together with nitrofluorene for TA98 and sodium azide for TA100 without (-S9) metabolic activation, and 2-aminoantracene for TA98 and TA100 with metabolic (+S9) activation. Oxygenated monoterpenes especially camphor (30.21%), 1,8-cineole (23.7%) and trans-Pinocarveol (12.28%) were the major components of the oil of A. ciniformis. Bactericidal kinetics of this oil indicated that Acinetobacter baumannii is the most vulnerable one (MIC = 0.02 mg/mL, MBC = 0.04 mg/mL, Dvalue = 3.57 min). The oil displayed an excellent cytotoxic action toward the human tumor cell line (IC50 = 19.64 µg/mL). The oil of A. ciniformis showed excellent antimutagenicity effect on the 2-nitrofluorene, in the strain of S. typhimurium TA98, without the presence of metabolic activation.

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Section: Discussionmentioning

confidence: 99%

Chemical Constituents and In Vitro Anticancer, Cytotoxic, Mutagenic and Antimutagenic Activities of Artemisia Diffusa

Taherkhani

2015

Pharm Chem J

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“…Tel: +98 21 44492258. Within this family, Artemisia is included into the trible Anthemideae and comprises itself of over 500 species (Mozaffarian, 1996). The genus Artemisia has always been of great botanical and pharmaceutical interest and is useful in traditional medicines for the treatment of a variety of diseases and complaints (Rustaiyan and Masoudi., 2011;Firouzni et al, 2008). Some Artemisia species has been investigated chemically and the presence of monoterpenes, sesquiterpenes, specially sesquiterpene lactones and chemical composition of essential oil reported.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antimicrobial activity, antioxidant and total phenolic content within the leaves essential oil of Artemisia absinthium L. growing wild in Iran

Taherkhani¹

2013

Afr. J. Pharm. Pharmacol.

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Water-distilled essential oil from the leaves of Artemisia absinthium L. collected from Ardabil, northwestern Iran, was analyzed by Gas chromatography and mass spectrometry (GC and GC-MS). In the leaf oil of A. absinthium, 19 components, which represented 100% of the total composition were identified. 1,8-Cineole (36.46%), borneol (25.99%) and camphor (10.20%) were the major components in this oil. The leaves of A. absinthium was investigated to analyze their antimicrobial activity, antioxidant activity and total phenolic content. The present study revealed that the leaf essential oil of A. absinthium indicated significant activity against Candida albicans. Killing kinetics of various microorganisms treated with leaf oil of A. absinthium indicated that C. albicans is the most vulnerable. The total phenol contents of the leaf oil of A. absinthium was determined to be 168.67 ± 9.50 μg gallic acid equivalent/mg sample. Antioxidative properties of the leaves essential oil of A. absinthium was determined by 3 methods: The Ferric-reducing antioxidant power (FRAP), radical-scavenging capacity of the oil or bleaching of 2,20-diphenylpicrylhydrazyl (DPPH) and β-Carotene-linoleic acid assay. The ferric reducing power of the essential oils was determined to be 10.67 ± 0.45 gallic acid equivalent (mg/g). The leaf essential oil of A. absinthium reduced the concentration of DPPH free radical (61.4 ± 1.4%, 10 mg/ml of essential oil) with an efficacy lower than that of reference oil Thymus x-porlock (69.3% inhibition). IC 50 for DPPH radical-scavenging activity was 5.85 μg/ml. In β-carotene-linoleic acid test system, oxidation of linoleic acid was effectively inhibited by A. absinthium oil (58.56 ± 2.5%, amount of essential oil 0.625 mg/ml). The results suggest application of A. absinthium oil as a natural antioxidant agent.

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“…Phytochemical investigations on volatile oil of A. biennis led to the identification of camphor and (E)-beta-farnesene as the major components from the plant species growing in Iranian and Canadian habitats, respectively ( 10 11 ). Monoterpenoids such as camphor, myrcene, linalool, and sesquiterpenoids like davanone have been reported as the main constituents in the volatile oil of A. ciniformis ( 12 13 14 ). The leishmanicidal ( 15 ), antimalarial ( 16 ), free radical-scavenging, and cytoprotective ( 17 18 19 ) effects of both species have been previously reported.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the cytotoxic effects of different fractions of Artemisia ciniformis and Artemisia biennis on B16/F10, PC3 and MCF7 Cells

Ramazani¹,

Tayarani‐Najaran²,

Shokoohinia³

et al. 2020

Res Pharma Sci

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Background and purpose: Artemisia is one of the well-known herbal medicinal plants for antimicrobial, insecticidal, antioxidant, and antimalarial activities. The antiproliferative effects of dichloromethane extracts of Artemisia biennis ( A. biennis ) and A. ciniformis and the petroleum ether extract of A. ciniformis have been demonstrated previously on human cancerous cell lines. In the current study, further fractionation was carried out on the aforementioned extracts and their cytotoxic effects were evaluated on three human cancer cell lines; B16/F10, PC3, and MCF7. F1 to F16, F1’ to F11’, and F1” to F10” were resulted from the fractionation of dichloromethane extracts of A. biennis, A. ciniformis , and petroleum ether extract of A. ciniformis , respectively. Experimental approach: The cytotoxic effects of 16 (F1-F16), 11 (F1’-F11’) and 10 (F1”-F10”) fractions, on B16/F10, PC3, and MCF7 cell lines were assessed using resazurin to measure viability and propidium iodide staining (sub G1) and flow cytometry to detect apoptosis. Findings / Results: The results showed that, some fractions at 100 μg/mL decreased cell viability. F2” in B16/F10 cells, F2, F4-F6, F10’, F11’, and F2” in PC3 cells, and F10’, F11’, and F2” in MCF7 significantly decreased cell viability in a concentration-dependent manner (12.5-50 μg/mL). Among different fractions, F2” demonstrated the most potent cytotoxic effects on cancer cell lines ( P < 0.001). All of the mentioned fractions (except F11’ on PC3 cells) increased the number of apoptotic cells and showed the cytotoxic effects on cancer cells compared with the control group. Conclusion and implications: A. biennis and A. ciniformis are suggested as the potential sources of cytotoxic phytochemicals. The probable presence of terpenoids, steroids, and alkaloids in the selected fractions is proposed based on the preliminary phytochemical study.

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Composition of the essential oil of Artemisia ciniformis, A. kopetdaghensis, and A. khorasanica in Iran

Cited by 14 publications

References 14 publications

Chemical Constituents and In Vitro Anticancer, Cytotoxic, Mutagenic and Antimutagenic Activities of Artemisia Diffusa

Chemical Constituents and In Vitro Anticancer, Cytotoxic, Mutagenic and Antimutagenic Activities of Artemisia Diffusa

Chemical composition, antimicrobial activity, antioxidant and total phenolic content within the leaves essential oil of Artemisia absinthium L. growing wild in Iran

Comparison of the cytotoxic effects of different fractions of Artemisia ciniformis and Artemisia biennis on B16/F10, PC3 and MCF7 Cells

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