Composition of the Essential Oil of Wild Growing <i>Artemisia vulgaris</i> from Erie, Pennsylvania

Williams, J. L. R.; Saleh, Ayman; Acharya, Dom N.

doi:10.1177/1934578x1200700524

Cited by 9 publications

(10 citation statements)

References 26 publications

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“…Camphor (12.0 – 30.0%) was determined as a major constituent in the oils 35 – 40 (detailed composition of the oil 39 is presented in Table ). Camphor is one of the most frequently found main components in EOs of A. vulgaris native to various word countries . Oils 41 – 44 attributed to the same subcluster were characterized by major compound one of the davanones isomers, davanone (7.0 – 27.9%, numbers 41, 43, and 44) or davanone B (16.1%, Table , sample 42).…”

Section: Resultsmentioning

confidence: 99%

“…The following compounds were detected as the second or third main components: β ‐pinene, sabinene, trans ‐thujone, camphor, borneol, cis ‐chrysanthenyl acetate, germacrene D, γ ‐muurolene, caryophyllene and its oxide, spathulenol, and davanone. 1,8‐Cineole has been described as a common compound among principal constituents in the mugwort oils from Croatia, France, Romania, Serbia, the USA, India, Iran, and Nepal . Oils 20, 21, and 24, containing sabinene (11.8 – 16.4%) as the first principal compound; 1,8‐cineole (6.9 – 7.5%) and germacrene D (6.8 – 14.4%) as other two main constituents, were attributed to the same subcluster in cluster IV .…”

Section: Resultsmentioning

confidence: 99%

“…Aerial parts Syria [28] a-Thujone (56.1), [16] Caryophyllene (24.1), b-cubebene (12.0), b-elemene (6.0) var. indica Maxim, leaves Vietnam [5] cis-Chrysanthenyl acetate (39.6), p-cymene (17.2), b-phellandrene (11.4), trans-2-hexenal (5.0) Aerial parts Canada (Montreal) [33] Caryophyllene oxide ( Aerial parts, leaf and bud oils the USA (Pennsylvania, Erie) [30] a-Thujone (≤24.3), b-caryophyllene (≤17.5), santolina triene (10.0),…”

Section: Aerial Partsmentioning

confidence: 99%

“…A. vulgaris synthesizes many bioactive compounds, such as terpenoids, sesquiterpene lactones, flavonoid glycosides, coumarins, carotenoids, resins, alkaloids, and polysaccharides. Essential oil (EO) makes a significant contribution to plant biological activity as well, and for that reason the chemical composition was a subject of many studies (and references cited therein). The most important and characteristic components of mugwort oils are α ‐, β ‐pinene, myrcene, phellandrene, cis ‐, trans ‐thujone, camphor, 1,8‐cineole, artemisia ketone, borneol, verbenone, caryophyllene and its oxide, isobornyl isobutyrate, artemisia alcohol, chrysanthenol, cis‐, trans ‐chrysanthenyl acetate, lyratol, α ‐humulene, davanone B, and elemol ( Table ).…”

Section: Introductionmentioning

confidence: 99%

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Chemical Polymorphism of Essential Oils of Artemisia vulgaris Growing Wild in Lithuania

Judžentienė

Būdienė

2018

Chemistry & Biodiversity

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Compositional variability of mugwort (Artemisia vulgaris L.) essential oils has been investigated in the study. Plant material (over ground parts at full flowering stage) was collected from forty-four wild populations in Lithuania. The oils from aerial parts were obtained by hydrodistillation and analyzed by GC(FID) and GC/MS. In total, up to 111 components were determined in the oils. As the major constituents were found: sabinene, 1,8-cineole, artemisia ketone, both thujone isomers, camphor, cis-chrysanthenyl acetate, davanone and davanone B. The compositional data were subjected to statistical analysis. The application of PCA (Principal Component Analysis) and AHC (Agglomerative Hierarchical Clustering) allowed grouping the oils into six clusters. AHC permitted to distinguish an artemisia ketone chemotype, which, to the best of our knowledge, is very scarce. Additionally, two rare cis-chrysanthenyl acetate and sabinene oil types were determined for the plants growing in Lithuania. Besides, davanone was found for the first time as a principal component in mugwort oils. The performed study revealed significant chemical polymorphism of essential oils in mugwort plants native to Lithuania; it has expanded our chemotaxonomic knowledge both of A. vulgaris species and Artemisia genus.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Aerial Partsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical Polymorphism of Essential Oils of Artemisia vulgaris Growing Wild in Lithuania

Judžentienė

Būdienė

2018

Chemistry & Biodiversity

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“…In addition, extracts from A. vulgaris have been shown to sensitize MDA-MB-231 and MDA-MB-468 breast cancer cells to TRAIL [ 22 ]. In a recent study, we have isolated the essential oils from A. vulgaris aerial parts (leaves and buds) and identified its chemical composition using gas chromatography (GC)/mass spectrometry (MS) analyses [ 23 ]. Our results have identified 22 compounds in A. vulgaris L. essential oils which majorly include germacrene D (25%), caryophyllene (20%), alpha-zingiberene (15%) and borneol (11%) in the leaf oil, while the buds are rich in 1,8-cineole (32%), camphor (16%), borneol (9%), and caryophyllene (5%).…”

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity of Artemisia vulgaris L. essential oil is mediated by a mitochondria-dependent apoptosis in HL-60 leukemic cell line

Saleh

Aljada

Rizvi

et al. 2014

BMC Complement Altern Med

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BackgroundThe essential oil (EO) of Artemisia vulgaris L. has been traditionally used worldwide for treating a large number of diseases. Although major components in A. vulgaris EO have been shown to inhibit growth of different cancer cells, as pure compounds or part of other plants extracted oil, no information is known about its anti-proliferative activities. Therefore, the current investigation has evaluated the toxicity of the plant extracted oil from buds (AVO-b) and leaves (AVO-l) and characterized their growth inhibitory effects on cancer cells.MethodsAVO-b and AVO-l from A. vulgaris L. were extracted by hydrodistillation, and their effect on the viability of human HL-60 promyelocytic leukemia and various other cancer cell lines was tested using MTT assay. Flow cytometric analysis of apoptosis, DNA fragmentation assay, caspases enzymatic activities and Western blotting were used to determine the apoptotic pathway triggered by their action on HL-60 cells.ResultsLow concentrations of AVO-b and AVO-l inhibited the growth of HL-60 cells in a dose- and time-dependent manner. Employing flow cytometric, DNA fragmentation and caspase activation analyses, demonstrated that the cytotoxic effect of the oils is mediated by a caspase-dependent apoptosis. Kinetic studies in the presence and absence specific caspase inhibitors showed that activation of caspase-8 was dependent and subsequent to the activation of caspases-9 and -3. In addition, the essential oil caused a disruption of the mitochondrial transmembrane potential (ΔΨm), increased the release of cytochrome c to the cytosol, and altered the expression of certain members of Bcl-2 family (Bcl-2, Bax and Bid), Apaf-1 and XIAP. Interestingly, low doses of AVO-b and AVO-1 also induced apoptosis in various cancer cell lines, but not in noncancerous cells.ConclusionsThe results demonstrate that the EO-induced apoptosis in HL-60 cells is mediated by caspase-dependent pathways, involving caspases-3, -9, and -8, which are initiated by Bcl-2/Bax/Bid-dependent loss of ΔΨm leading to release of cytochrome c to the cytoplasm to activate the caspase cascade. The finding that AVO-b and AVO-l are more efficient to induce apoptosis in different cancer cell lines than noncancerous cells, suggests that A. vulgaris might be a promising source for new anticancer agents.

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Artemisia absinthium-borne compounds as novel larvicides: effectiveness against six mosquito vectors and acute toxicity on non-target aquatic organisms

Govindarajan

Benelli

2016

Parasitol Res

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The eco-friendly control of mosquito vectors is a crucial challenge of public health importance. Here we evaluated the larvicidal potential of Artemisia absinthium essential oil (EO) and its three major chemical constituents against six mosquito vectors: Anopheles stephensi, Anopheles subpictus, Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Culex tritaeniorhynchus. The EO was obtained by leaf hydrodistillation. Its chemical composition was analyzed using gas chromatography-mass spectrometry. Major components were (E)-β-farnesene (31.6 %), (Z)-en-yn-dicycloether (11.12 %), and (Z)-β-ocimene (27.8 %). The EO was toxic effect against larval populations of An. stephensi, An. subpictus, Ae. aegypti, A e . a l b o p i c t u s, C x . q u i n q u e f a s c i a t u s , and C x . tritaeniorhynchus, with LC 50 values of 41. 85, 52.02, 46.33, 57.57, 50.57, and 62.16 μg/ml. (E)-β-farnesene, (Z)-en-yndicycloether, and (Z)-β-ocimene were highly effective on An. stephensi (LC 50 = 8.13, 16.24 and 25.84 μg/ml) followed by An. subpictus (LC 50 = 10.18, 20.99, and 30.86 μg/ml), Ae. aegypti (LC 50 = 8.83,17.66, and 28.35 μg/ml), Ae. albopictus (LC 50 = 11.38,23.47, and 33.72 μg/ml), Cx. quinquefasciatus (LC 5 0 = 9.66, 19.76, and 31.52 μ g/ml), and Cx. tritaeniorhynchus (LC 50 = 12.51,25.88, and 37.13 μg/ml). Notably, the EO and its major compounds were safer to the non-target organisms Chironomous circumdatus, Anisops bouvieri and Gambusia affinis, with LC 50 values ranging from 207.22 to 4385 μg/ml. Overall, our results highlight that (E)-β-farnesene, (Z)-en-yn-dicycloether, and (Z)-β-ocimene from the A. absinthium EO represent promising eco-friendly larvicides against six key mosquito vectors with moderate toxicity against non-target organisms.

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Composition of the Essential Oil of Wild Growing Artemisia vulgaris from Erie, Pennsylvania

Cited by 9 publications

References 26 publications

Chemical Polymorphism of Essential Oils of Artemisia vulgaris Growing Wild in Lithuania

Chemical Polymorphism of Essential Oils of Artemisia vulgaris Growing Wild in Lithuania

In vitro cytotoxicity of Artemisia vulgaris L. essential oil is mediated by a mitochondria-dependent apoptosis in HL-60 leukemic cell line

Artemisia absinthium-borne compounds as novel larvicides: effectiveness against six mosquito vectors and acute toxicity on non-target aquatic organisms

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