Composition of Ophiopogon Polysaccharide, Notoginseng Total Saponins and Rhizoma Coptidis Alkaloids Inhibits the Myocardial Apoptosis on Diabetic Atherosclerosis Rabbit

Jin, Zhaohui; Gao, Pu; Liu, Zheng‐Tang; Jin, Bing Jie; Song, Guang-Yi; Xiang, Tianyuan

doi:10.1007/s11655-018-3014-2

Cited by 7 publications

(8 citation statements)

References 19 publications

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“…It has also been affirmed that treatment by flavone (20) and flavonoid (21) mitigates the renal dysfunction, oxidative stress, and fibrosis in diabetic rats, and inhibits inflammation and apoptosis in the kidney tissue. Former observations have confirmed the beneficial properties of nitrogenous compounds, such as alkaloids, on preventing the apoptosis of different organs (22,23).…”

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confidence: 89%

“…It has also been explored that P. harmala leaf extracts benefit from antioxidant (25), antibacterial (26,27), and cytotoxic (28) activities due to polyphenol compositions. Considering the effective role of alkaloids and flavonoids in the inhibition of apoptosis (19)(20)(21)(22)(23) and very scant investigations of the anti-apoptotic properties of P. harmala, the current research was undertaken to evaluate the anti-apoptotic effect of the leaf extract of P. harmala, based on its alkaloids and flavonoids, in type 2 diabetic model rats.…”

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confidence: 99%

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Assessment of the Anti-apoptotic Effects of Peganum harmala Leaf Extract on Type 2 Diabetes in the Kidney of Male Wistar Rats

Kajbaf

Oryan

Ahmadi

et al. 2020

Avicenna J Med Biochem

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Background: Growing evidence has shown that the apoptosis of cells plays an important role in the advancement of the Diabetic nephropathy (DN). Objectives: This study attempted to discover the therapeutic potential of Peganum harmala leaf extract in the apoptosis of diabetic kidney disease. Methods: In the present experimental research, 32 male Wistar rats were studied, and diabetes was induced by streptozotocin (STZ) (65 mg/kg). The animals were randomly divided into four groups (n=8, in each group) as follows: control, diabetic, control+leaf extract, diabetic+leaf extract. For our purposes, the methanolic extract of P. harmala leaves (150 mg/kg) was given by gavage for 28 days. Flow cytometry and real-time polymerase chain reaction (PCR) analyses were utilized to determine the percentages of apoptotic cells. Also, histological alterations and blood biochemical parameters were evaluated. Results: The P. harmala leaf extract has a high amount of flavonoids (25.84%), a lower percentage of alkaloids (0.14%), and some antioxidant properties. Serum urea (P<0.001) and apoptosis (P<0.05) significantly elevated in diabetic rats relative to the control ones. The mean of fasting blood creatinine, urea, and albumin level was not significantly changed in diabetic+leaf extract rats as compared to the diabetic ones. Histopathological results also displayed that diabetic complications in the kidney could not be improved following treatment by the leaf extract of P. harmala. In addition, the leaf extract could not significantly reduce the apoptosis and caspase-3 expression compared to diabetics in renal cells. Conclusion: Based on our findings, the leaf extract of P. harmala is unable to inhibit apoptosis in the diabetic kidney model.

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confidence: 89%

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confidence: 99%

Assessment of the Anti-apoptotic Effects of Peganum harmala Leaf Extract on Type 2 Diabetes in the Kidney of Male Wistar Rats

Kajbaf

Oryan

Ahmadi

et al. 2020

Avicenna J Med Biochem

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“…Toxicology studies play a crucial role in understanding the safety of traditional Chinese medicine. However, toxicological studies of tra- (Lien et al, 2017;Qi et al, 2020) Polygoni Multiflori Radix TSG Inhibit inflammation (Li et al, 2020) Polygoni Multiflori Radix TSG Improve lipid disorders (Li et al, 2020) Polygoni Multiflori Radix TSG Regulate gut microbiome (Li et al, 2020) Polygoni Multiflori Radix THSG Improve endothelial function (Yi, Nguyen, Won, Kim, & Ryoo, 2017) Fructus Lycii LBP Inhibit VSMCs proliferation (Yi et al, 2017; Fructus Lycii LBP Improve lipid disorders Zhu et al, 2015) Fructus Lycii LBP Inhibit inflammation (Zhu et al, 2015) Coptidis Rhizoma CONR Inhibit apoptosis (Jin et al, 2020;Zhu et al, 2015) Coptidis Rhizoma Berberine Improve endothelial function (Jin et al, 2020;Tan et al, 2020) Coptidis Rhizoma Coptidis Rhizoma Inhibit inflammation (Feng et al, 2017;Tan et al, 2020) Coptidis Rhizoma Coptidis Rhizoma Improve lipid disorders (Feng et al, 2017) Notes:…”

Section: Toxicologymentioning

confidence: 99%

Therapeutic potential of traditional Chinese medicine in atherosclerosis: A review

Liu

Zhu

Chen

et al. 2022

Phytotherapy Research

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Atherosclerosis is the onset of endothelial cell damage and is characterized by abnormal accumulation of fibrinogen and lipid in large and middle arteries. Recent researches indicate that traditional Chinese medicine including Notoginseng Radix et Rhizoma, Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, Ginseng Radix et Rhizoma, Fructus Crataegi, Glycyrrhizae Radix et Rhizoma, Polygoni Multiflori Radix, Fructus Lycii, and Coptidis Rhizoma have therapeutic effects on atherosclerosis. Furthermore, the pharmacological roles of these kinds of traditional Chinese medicine in atherosclerosis refer to endothelial function influences, cell proliferation and migration, platelet aggregation, thrombus formation, oxidative stress, inflammation, angiogenesis, apoptosis, autophagy, lipid metabolism, and the gut microbiome. Traditional Chinese medicine may serve as potential and effective anti‐atherosclerosis drugs. However, a critical study has shown that Notoginseng Radix et Rhizoma may also have toxic effects including pustules, fever, and elevate circulating neutrophil count. Further high‐quality studies are still required to determine the clinical safety and efficacy of traditional Chinese medicine and its active ingredients.

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“…Previous studies have shown that the main components of MSHC are Panax notoginseng saponins (PNS), Ophiopogon polysaccharide, and Coptis alkaloids. [20]. e main monomer component in Ophiopogon polysaccharide is Polysaccharide MGD-1 [21].…”

Section: Mshc Acquisitionmentioning

confidence: 99%

Exploring the Regulatory Mechanism of Modified Huanglian Maidong Decoction on Type 2 Diabetes Mellitus Biological Network Based on Systematic Pharmacology

Zhang

Jin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the mechanism of modified Huanglian Maidong decoction (Maidong-Sanqi-Huanglian Compounds, MSHCs) intervention in type 2 diabetes mellitus (T2DM). Method. This study used PubChem and SciFinder to collect the molecular structure of MSHCs, used PharmMapper to predict the potential targets of MSHC, and combined them with the T2DM gene to construct MSHC-T2DM protein-protein interaction (PPI) network. The plugin MCODE in Cytoscape 3.7.1 was then used to perform cluster analysis on the MSHC-T2DM PPI network. The genes and targets were input into DAVID for Gene Ontology (GO) and pathway enrichment analysis. Finally, animal experiments were performed to verify the therapeutic effect of MSHC on T2DM. Results. Several T2DM-related targets, clusters, signaling pathways, and biological processes are found. The experimental results showed that compared with the blank group, the content of fasting blood glucose (FBG) in the model group was higher ( P < 0.01 ). Compared with the model group, the content of FBG decreased and the insulin level increased in the MSHC medium-dose (0.15 g/kg) and high-dose (0.45 g/kg) groups and metformin group after 4 weeks of drug administration ( P < 0.05 ). MSHC can also improve blood liquid levels and inflammatory factor levels ( P < 0.05 ). Conclusion. MSHC may achieve therapeutic effects through regulating the T2DM-related targets, biological processes, and pathways, such as insulin resistance, energy metabolism, oxidative stress, and inflammation, found in this research.

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Composition of Ophiopogon Polysaccharide, Notoginseng Total Saponins and Rhizoma Coptidis Alkaloids Inhibits the Myocardial Apoptosis on Diabetic Atherosclerosis Rabbit

Cited by 7 publications

References 19 publications

Assessment of the Anti-apoptotic Effects of Peganum harmala Leaf Extract on Type 2 Diabetes in the Kidney of Male Wistar Rats

Assessment of the Anti-apoptotic Effects of Peganum harmala Leaf Extract on Type 2 Diabetes in the Kidney of Male Wistar Rats

Therapeutic potential of traditional Chinese medicine in atherosclerosis: A review

Exploring the Regulatory Mechanism of Modified Huanglian Maidong Decoction on Type 2 Diabetes Mellitus Biological Network Based on Systematic Pharmacology

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