Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer

Hang, Zhongci; Tong, Lei; Zeng, Zehua; Cai, Shanglin; Bi, Wangyu; Du, Hongwu

doi:10.1016/j.biopha.2021.112343

Cited by 31 publications

(29 citation statements)

References 169 publications

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“…Epidemiological studies have demonstrated that the composition of the intestinal flora can either facilitate or hinder the possibility of developing a HNDD or cancer. As a recent study shows, subjects developing Alzheimer's disease or Parkinson's disease will be somewhat protected against developing a malignant tumor and viceversa [72]. This antagonism does not affect genetic neurodegenerative disorders, such as Huntington's chorea or ALS, although in both diseases the composition of the intestinal flora is altered.…”

Section: The Role Of Gut Microbiota In Hndds and Cancermentioning

confidence: 99%

“…Gut dysbiosis increases intestinal permeability and impairs Treg cells function, leading to inflammation and oxidative stress [71,72] 1.1. On pH-related etiology and pathogenesis of cancer in the post Warburg era.…”

Section: Hndds and Msmentioning

confidence: 99%

“…In summary, all the available data seem to indicate that gut dysbiosis is another important metabolic link between the development of HNDDs and cancer. What both kind of diseases share is the development of intestinal inflammation with a secondary damage of intestinal permeability and impaired Treg (regulatory T cell) function and immunity [72] (Box 1). Since both opposite pathologies have a similar departure point, at least in the case of non-genetic causes, the question that now arises is: what is the cause of the etiopathogenic differences between HNDDs and cancer regarding intestinal dysbiosis?…”

Section: The Role Of Gut Microbiota In Hndds and Cancermentioning

confidence: 99%

“…Since both opposite pathologies have a similar departure point, at least in the case of non-genetic causes, the question that now arises is: what is the cause of the etiopathogenic differences between HNDDs and cancer regarding intestinal dysbiosis? A first approach to this question comes from a recent review by Hang et al [72]. These authors describe the effects of the six most frequent taxa of intestinal bacteria on the production of cancer or HNDDs and/or the improvement of each of these pathologies.…”

Section: The Role Of Gut Microbiota In Hndds and Cancermentioning

confidence: 99%

See 3 more Smart Citations

Hydrogen Ion Dynamics as the Fundamental Link Between Neurodegenerative Diseases and Cancer. Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis in Multiple Sclerosis

Harguindey¹,

Alfarouk²,

Orozco³

et al. 2022

Preprint

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The pH-related metabolic paradigm has rapidly grown in cancer research and treatment. In this contribution, this recent oncological perspective has been laterally for the first time in order to integrate neurodegeneration within the energetics of the cancer acid-base conceptual frame. At all levels of study, molecular, biochemical, metabolic and clinical, the intimate nature of both processes appears to be opposite mechanisms occurring at the far ends of a physiopathological intracellular pH/extracellular pH (pHi/pHe) spectrum. This wide-ranged original approach now permits an increase in our understanding of these opposite processes, cancer and neurodegeneration, and, as a consequence, allows to propose new avenues of treatment based upon the intracellular and microenvironmental hydrogen ion dynamics regulating and deregulating the biochemistry and metabolism of both cancer and neural cells. Under the same perspective, the etiopathogenesis and special characteristics of multiple sclerosis (MS) becomes an excellent model for the study of neurodegenerative diseases and, utilizing this pioneering approach, we find that MS appears to be a metabolic disease even before an autoimmune one. Also within this paradigm, several important aspects of MS, from mitochondrial failure to microbiota functional abnormalities, are analyzed in depth.

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Section: The Role Of Gut Microbiota In Hndds and Cancermentioning

confidence: 99%

Section: Hndds and Msmentioning

confidence: 99%

Section: The Role Of Gut Microbiota In Hndds and Cancermentioning

confidence: 99%

Section: The Role Of Gut Microbiota In Hndds and Cancermentioning

confidence: 99%

See 2 more Smart Citations

Hydrogen Ion Dynamics as the Fundamental Link Between Neurodegenerative Diseases and Cancer. Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis in Multiple Sclerosis

Harguindey¹,

Alfarouk²,

Orozco³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies have demonstrated that the composition of the intestinal flora can either facilitate or hinder the possibility of developing a HNDD or cancer. As a recent study showed, subjects developing Alzheimer’s disease or Parkinson’s disease will be somewhat protected against developing a malignant tumor, and vice versa [ 78 ]. This antagonism does not affect genetic neurodegenerative disorders, such as Huntington’s chorea or ALS, although in both diseases the composition of the intestinal flora is altered.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Ion Dynamics as the Fundamental Link between Neurodegenerative Diseases and Cancer: Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis on Multiple Sclerosis

Harguindey¹,

Alfarouk

Orozco³

et al. 2022

IJMS

View full text Add to dashboard Cite

The pH-related metabolic paradigm has rapidly grown in cancer research and treatment. In this contribution, this recent oncological perspective has been laterally assessed for the first time in order to integrate neurodegeneration within the energetics of the cancer acid–base conceptual frame. At all levels of study (molecular, biochemical, metabolic, and clinical), the intimate nature of both processes appears to consist of opposite mechanisms occurring at the far ends of a physiopathological intracellular pH/extracellular pH (pHi/pHe) spectrum. This wide-ranging original approach now permits an increase in our understanding of these opposite processes, cancer and neurodegeneration, and, as a consequence, allows us to propose new avenues of treatment based upon the intracellular and microenvironmental hydrogen ion dynamics regulating and deregulating the biochemistry and metabolism of both cancer and neural cells. Under the same perspective, the etiopathogenesis and special characteristics of multiple sclerosis (MS) is an excellent model for the study of neurodegenerative diseases and, utilizing this pioneering approach, we find that MS appears to be a metabolic disease even before an autoimmune one. Furthermore, within this paradigm, several important aspects of MS, from mitochondrial failure to microbiota functional abnormalities, are analyzed in depth. Finally, and for the first time, a new and integrated model of treatment for MS can now be advanced.

show abstract

Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones

Hang²,

Tong³

et al. 2022

Neurochem Res

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Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer

Cited by 31 publications

References 169 publications

Hydrogen Ion Dynamics as the Fundamental Link Between Neurodegenerative Diseases and Cancer. Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis in Multiple Sclerosis

Hydrogen Ion Dynamics as the Fundamental Link Between Neurodegenerative Diseases and Cancer. Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis in Multiple Sclerosis

Hydrogen Ion Dynamics as the Fundamental Link between Neurodegenerative Diseases and Cancer: Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis on Multiple Sclerosis

Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones

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