Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography–mass spectrometry and probability-based data deconvolution

Bos, Tijmen S.; Desport, Jessica S.; Buijtenhuijs, Ab; Purmova, Jindra; Karlson, Leif; Pirok, Bob W.J.; Schoenmakers, Peter J.; Somsen, Govert W.

doi:10.1016/j.chroma.2022.463758

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…In our group, Bos et al studied the CCD of cellulose ethers by performing offline hydrolysis of the glycosidic bonds by acid hydrolysis. 115 This resulted in substituted monomers which were analyzed by LC-MS to obtain the substitution degree and composition of b-glucose monomers. 113 Another approach to obtain the correlation between the MWD and CCD that does not utilize MW reduction is derivatization.…”

Section: Characterizing Synthetic Polymersmentioning

confidence: 99%

Sample transformation in online separations: how chemical conversion advances analytical technology

van der Zon,

Verduin,

van den Hurk

et al. 2024

Chem. Commun.

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Section: Characterizing Synthetic Polymersmentioning

confidence: 99%

Sample transformation in online separations: how chemical conversion advances analytical technology

van der Zon,

Verduin,

van den Hurk

et al. 2024

Chem. Commun.

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“…Furthermore, mixed ethers with methyl and/or ethyl exist. These HEMC [ 8 , 9 ], MEHEC, EHEC [ 10 ], and HPMC [ 11 , 12 ] are characterized by comparably low MDS values, but tandem reaction is already observed at MDS as low as 0.17 [ 9 , 11 , 12 ]. Their characteristics depend on the molar mass and the type of substituents, as well as their DS and MDS values, respectively.…”

Section: Introductionmentioning

confidence: 99%

Potential of ion mobility mass spectrometry in cellulose ether analysis: substitution pattern of hydroxyethyl celluloses

Mischnick,

Schleicher

2024

Anal Bioanal Chem

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Ion mobility mass spectrometry (ESI-tims-ToF–MS, syringe pump infusion) has been applied to glucose and oligosaccharide ethers derived from hydroxyethyl-methyl celluloses (HEMC) and hydroxyethyl celluloses (HEC) after permethylation and partial depolymerization: by hydrolysis without or with subsequent reductive amination with m-amino benzoic acid (mABA) or by reductive cleavage. As model compounds without tandem substitution methoxyethylated methylcellulose was used. Regioisomeric glucose ethers were separated according to their ion mobility, and positions of substitution could be assigned. Glucose ethers including isomers with tandem substitution showed additional signals with a smaller collision cross-section (CCS) than core-substituted isomers. Positional isomers of cellobiose ethers were only partly resolved due to too high complexity but showed a characteristic fingerprint that might allow classifying samples. Relative intensities of signals of glucose ether isomers could only be quantified in case of ABA derivatives with its fixed charge, while sodium adducts of methoxyethyl ethers showed an influence of the MeOEt position on ion yield. Results were in very good agreement with reference analysis. [M + Na]+ adducts of α- and β-anomers of glucose derivatives were separated in IM, complicating position assignment. This could be overcome by reductive cleavage of the permethylated HE(M)C yielding 1,5-anhydroglucitol-terminated oligosaccharides, showing the best resolved fingerprints of the cellobiose ethers of a particular cellulose ether. With this first application of ion mobility MS to the analysis of complex cellulose ethers, the promising potential of this additional separation dimension in mass spectrometry is demonstrated and discussed. Graphical abstract

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Fingerprinting of hydroxy propyl methyl cellulose by comprehensive two-dimensional liquid chromatography-mass spectrometry of monomers resulting from acid hydrolysis

Bos,

Pirok,

Karlson

et al. 2024

Journal of Chromatography A

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Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography–mass spectrometry and probability-based data deconvolution

Cited by 3 publications

References 37 publications

Sample transformation in online separations: how chemical conversion advances analytical technology

Sample transformation in online separations: how chemical conversion advances analytical technology

Potential of ion mobility mass spectrometry in cellulose ether analysis: substitution pattern of hydroxyethyl celluloses

Fingerprinting of hydroxy propyl methyl cellulose by comprehensive two-dimensional liquid chromatography-mass spectrometry of monomers resulting from acid hydrolysis

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