Composition characteristics of the gut microbiota in infants and young children of under 6 years old between Beijing and Japan

Abstract

Background: The composition of intestinal flora in Chinese and Japanese has been reported in many studies but that in infants aged 0-6 years old has not been studied yet. Methods:The distribution characteristics of the fecal flora of infants in Beijing (n=84) and Japan (n=53) were analyzed using 16S rRNA gene sequencing analysis.Results: This study showed the higher relative abundance of Erysipelotrichaceae_ UCG-003 and Anaerostipes in male group that of Ruminiclostridium, Eubacterium, Senegalimassilia and Senegalimassilia in female group, especially Senegalimassilia, which was not detected in male group. Defecation trait groups indicated significantly higher relative abundance of Bifidobacterium in abnormal bowel trait group than that in the normal group (P<0.05). The feeding groups' analysis showed significantly higher relative abundance of Bifidobacterium and Enterococcus and lower abundance of Bacteroides and Lacetospirillaceae in the breast-feeding group than that in the formula feeding and mixed-feeding groups. The relative abundance of Parasutterella and Ruminococcaceae_UCG-003 in the halitosis group was significantly higher than that in the normal group.The comparison of cold and fever group and normal group indicated significantly higher relative abundance of Erysipelatoclostridium and lower relative abundance of Lachnospiraceae _UCG-001 in the fever and cold group than that in the normal group (P<0.05). The regional comparison of intestinal flora of Beijing and Japan showed significant increase in the relative abundance of Bacillus, Lactobacillus, Prevotella, megamonas and Veillonella in the intestinal flora of 0-6 years old infants in Beijing.Conclusions: These findings improve the understanding of intestinal bacterial and viral communities of infants from the two Asian countries.

Metagenomic Analysis Reveals A Gut Microbiota Structure and Function Alteration between Healthy and Diarrheic Juvenile Yaks

“…Eysipelatoclostridium is intricately linked to intestinal toxemia and diarrhea in mammals, with its toxins impacting host health through diverse pathways [60]. Furthermore, Eysipelatoclostridium has been implicated in developing necrotizing enterocolitis in preterm infants [61]. Parabacteroides, an antibiotic-resistant harmful bacterium in the gut, proliferates extensively when the host's gut microbiota is imbalanced, leading to diseases such as appendicitis, peritoneal inflammation, and bacteremia [62].…”

Intestinal Microbiota in Children with Anemia in Southern Peru through Next-Generation Sequencing Technology

“…Furthermore, studies show that this bacterium is associated with human metabolic syndrome and mice-induced obesity [ 32 , 33 , 34 ]. As for the Erysipelatoclostridium genus, studies show that its abundance is significantly higher in down-regulated immune systems [ 35 , 36 , 37 ]. Regarding the RA group, the genera that show the greatest taxonomic difference are Alloprevotella , MBA03 , and Phascolarctobacterium .…”

Clinical analysis of epidemiological characteristics and risk factors related to severe cases of 876 children with pulmonary tuberculosis in a children hospital of Chongqing, China.

“…Children who were infected with tuberculosis had a higher mortality rate. Compared to adults, children were more likely to affecting extrapulmonary tissues and organs, and were also more likely to progress to severe tuberculosis 4,5 . Because of the reasons such as the atypical clinical symptoms, low positive rate of pathogen detection, the diagnosis of tuberculosis in children were more di cult than adults, especially in the early stages of the disease, leading misdiagnosis and missed diagnosis, worsening of the condition, and even death 6 .At present, the clinical research related to tuberculosis in children had been ignored to a certain extent, and the research reports on the epidemiological characteristics of tuberculosis in children in different regions were still lacking.…”