Composition C-4 Induced Seizures: A Report of Five Cases

RDX Binds to the GABA A Receptor–Convulsant Site and Blocks GABA A Receptor–Mediated Currents in the Amygdala: A Mechanism for RDX-Induced Seizures

“…Previous reports have described seizures in humans after accidental acute consumption of RDX (Hollander and Colbach 1969; Kasuske et al 2009; Stone et al 1969; Woody et al 1986). Animal studies have also demonstrated the induction of seizures after RDX administration (Burdette et al 1988; Crouse et al 2006; Gust et al 2009; Macphail et al 1985; Martin and Hart 1974; Schneider et al 1977; Von Oettingen et al 1949).…”

Acute C4 Ingestion and Toxicity: Presentation and Management

“…C4 was used during the Vietnam War as part of demolition blocks; today, it is commonly used in both military and civilian settings for demolition and flares. C4 is composed of RDX (91%), dioctyl sebacate (5.3%), polyisobutylene (2.1%), and mineral/motor oil (1.6%) [1]. RDX (Cyclonite) is the primary compound responsible for the explosive nature of C4 and has been utilized due to its malleable nature, which allows it to be molded into any desired shape and redirect the direction of the resulting explosion [2].…”