Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil

Pavlović, Ivan; Petrović, Silvana; Radenković, Mirjana; Milenković, Marina; Couladis, Maria; Branković, Suzana; Drobac, Milica; Niketić, Marjan

doi:10.1016/j.foodchem.2011.07.043

Cited by 39 publications

(49 citation statements)

References 21 publications

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“…Recently, consumer demands have been dramatically on increase for agro-ecologically grown, fresh-like, and more nutritious foods (Saei-Dehkordi et al, 2014;Pavlović et al, 2012;Simic et al, 2004). The uses of essential oils and plant extracts have been already widespread in the pharmaceutical and cosmetic industries for the provision of flavor and fragrance.…”

Section: Introductionmentioning

confidence: 99%

Empirical prediction and validation of antibacterial inhibitory effects of various plant essential oils on common pathogenic bacteria

Evrendilek

2015

International Journal of Food Microbiology

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Section: Introductionmentioning

confidence: 99%

Empirical prediction and validation of antibacterial inhibitory effects of various plant essential oils on common pathogenic bacteria

Evrendilek

2015

International Journal of Food Microbiology

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“…heuffelii Griseb.e xH euff.i saperennial, Balkan-endemic plant, which grows mainly in Eastern Serbia, Southwestern Romania, and Western Bulgaria.P revious investigationsofthe underground parts of this plant demonstrated that the essentialoil and chloroform extract exhibitedstrong spasmolytic activity [10] [11].The essential oil additionally showed astrong antimicrobial potential [10]. Phytochemical investigation of the CHCl 3 extract allowed the isolation and identification of ten compounds,which belong to the classes of phenylpropanoids,p renyl-benzoyl-, prenyl-benzoylfuranone-, prenyl-furocoumarin-, and prenyl-dihydrofurochromone-type sesquiterpenoids, as well as sesquiterpene coumarins,w hile preliminaryH PLC analysis of the MeOH extract revealed the presence of two phenolic acids,o ne phenylpropanoid, and one sesquiterpene of the prenyl-furocoumarin type [11] [12].…”

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Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffeliiGriseb. ex Heuff. and Its Metabolites

Pavlović

Petrović

Milenković

et al. 2015

Chemistry & Biodiversity

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The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffelii Griseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5 μg/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5 μg/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2 μM, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5 μM, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2 μM). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 <11.0 μg/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50 =22.32±1.32 vs. 18.67±0.75μM).

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“…One such possibility is the use of essential oils as antibacterial additives. Many studies have reported that the essential oils extracted from many species of plants have potent activity against microorganisms (8,21,25). Considering their excellent antimicrobial function, natural essential oils possess great potential as antimicrobial agents in food systems to increase the safety and shelf life of foods.…”

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confidence: 99%

Chemical Composition, Antibacterial Activity, and Mechanism of Action of the Essential Oil from Amomum kravanh

Diao

Zhang

Feng

et al. 2014

Journal of Food Protection

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Amomum kravanh is widely cultivated and used as a culinary spice. In this work, the chemical composition of the essential oil obtained by hydrodistillation of A. kravanh fruits was analyzed by gas chromatography-mass spectrometry, and 34 components were identified. 1,8-Cineole (68.42%) was found to be the major component, followed by α-pinene (5.71%), α-terpinene (2.63%), and β-pinene (2.41%). The results of antibacterial tests showed that the sensitivities to the essential oil of different foodborne pathogens tested were different based on the Oxford cup method, MIC, and MBC assays, and the essential oil exhibited the best antibacterial activity against Bacillus subtilis, a gram-positive bacterium, and Escherichia coli, a gram-negative bacterium. Growth in the presence of Amomum kravanh at the MIC, as measured by monitoring optical density over time, demonstrated that the essential oil was bacteriostatic after 12 h to both B. subtilis and E. coli. Observations of cell membrane permeability, cell constituent release assay, and transmission electron microscopy indicated that this essential oil may disrupt the cell wall and cell membrane permeability, leading to leakage of intracellular constituents in both B. subtilis and E. coli.

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Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil

Cited by 39 publications

References 21 publications

Empirical prediction and validation of antibacterial inhibitory effects of various plant essential oils on common pathogenic bacteria

Empirical prediction and validation of antibacterial inhibitory effects of various plant essential oils on common pathogenic bacteria

Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffeliiGriseb. ex Heuff. and Its Metabolites

Chemical Composition, Antibacterial Activity, and Mechanism of Action of the Essential Oil from Amomum kravanh

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