Composition and biological activities of Salvia veneris Hedge growing in Cyprus

Toplan, Gizem Gülsoy; Kürkçüoğlu, Mine; Göğer, Fatih; İşcan, Gökalp; Ağalar, Hale Gamze; Mat, Afife; Başer, Kemal Hüsnü Can; Koyuncu, Mehmet; Sarıyar, Günay

doi:10.1016/j.indcrop.2016.11.055

Cited by 17 publications

(3 citation statements)

References 48 publications

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“…In particular, aqueous extracts of Salvia ringens [19] and Salvia amplexicaulis [18], both rich in kaempferol glycosides and/or in caffeic and rosmarinic acids, inhibited S. aureus strains (MIC of 15 and 40 mg/mL, respectively) and Gram-negative bacteria (MIC of 20 to ≥ 50 mg/mL). In turn, Toplan et al [21] found promising results when testing a methanolic extract of Salvia veneris (rich in rosmarinic acid and luteolin glucoside), which exhibited inhibitory effect against strains of S. aureus and S. epidermidis (MIC value of 0.25 and 2.0 mg/mL, respectively), and also against P. aeruginosa and S. typhimurium (MIC of 0.5 and 2.0 mg/mL, respectively) [21]. In their research, the authors found that essential oil showed relatively weak antimicrobial activity compared to the methanol extract, underlining the antibacterial role of polar extracts.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts

et al. 2019

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In the present study, aqueous extracts of Salvia africana, Salvia officinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 ± 7.5 μg/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. officinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple caffeic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH• (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of β-carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC50 values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC50 = 47.8 ± 2.1 μg/mL). In addition, the three sage aqueous extracts showed promising cytotoxic effect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts

et al. 2019

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“…The compound 9 (t R = 22.369 min) was identified as luteolin with literature (Toplan et al, 2017). The molecular formula is C 15 H 10 O 6 .…”

Section: Chemical Composition Analysis Of Tfcmk By Lc-ms/msmentioning

confidence: 95%

Extraction, Partial Identification and Bioactivities of Total Flavonoids from Carex meyeriana Kunth

Wang¹,

Wang²,

Yang³

et al. 2019

American Journal of Biochemistry and Biotechnology

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To date, knowledge associated with extraction, chemical constituents and bioactivities of Total Flavonoids from Carex meyeriana Kunth (TFCMK) that remains unclear. Therefore, this paper was designed to optimize the ethanol reflux extraction method by response surface methodology and determine the chemical constituents by Liquid Phase-Mass Spectrometry (HPLC-MS); additionally, the bioactivities including antioxidant, antibacterial and hemolysis test were also explored. The maximum TFCMK extraction yield of 6.248%±0.016% was obtained under the optimal conditions as follows: Ethanol concentration 50%, ratio of liquidto-solid 31 mL/g, extraction time 91 min and extraction temperature 71°C. Meanwhile, 9 compounds of TFCMK were identified by using LP-MS for the first time. In addition, TFCMK showed higher antioxidant activity compared with vitamin C, as evidenced by the lower EC 50 or IC 50 of TFCMK (reducing power assay: 0.125±0.025 mg/mL, DPPH radicals: 0.28± 0.031, ABTS + radicals:0.012 ± 0.005, hydroxyl radicals: 0.028±0.008 mg/mL; The EC 50 or IC 50 of VC 0.156±0.012, 0.059±0.019, 0.068±0.024 and 0.032±0.007 mg/mL, respectively.). Broth microdilution assays had demonstrated that the minimal inhibitory concentrations (MICs) of TFCMK on Bacillus pumilus, Bacillus subtilis and Escherichia coli were 0.625±0.0032, 1.250±0.0216 and 5.000±0.0205 mg/mL, respectively. Besides, the hemolysis rate (less than 5%) in vitro implied that TFCMK possessed a good blood compatibility. In summary, this paper provides evidences that TFCMK might be applied as an antioxidant and antibacterial agent in the pharmaceutical and chemical industries.

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“…They are used not only to treat several diseases but also for protecting health and wellbeing [1]. Additionally, many aromatic plants are cultivated as flavoring agents in perfumery, for use in food preservation, and to enhance flavors in various types of food [2,3]. Among these plants, Lamiaceae family, in particular, have gained more attention and taken an important place in traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Composition and Pharmacological Activities of Teucrium polium L. Collected from Eastern Turkey

2021

Turk J Chem

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Teucrium species that belong to the family Lamiaceae have been traditionally used for their medicinal properties. T. polium is one the most widespread members of the genus for its use in the treatment of several diseases. In this study, the essential oil and phenolic composition of the aerial parts from T. polium were assessed by GC-FID, GC/MS, and LC-MS/MS as well as for its total phenolic content. Several extracts such as n- hexane, chloroform, methanol, and infusion were prepared and their antimicrobial, antioxidant, and also acetylcholinesterase activities were studied. According to GC/MS results, β -caryophyllene (8.8%), t -cadinol (6.2%), ( E )-nerolidol (5%), α -cadinol (5.4%), and α-pinene (4.7%) were identified as main constituents of the essential oil. LC MS/MS analysis of the infusion and the methanol extract showed the presence of 15 phenolic compounds. Moreover, the total phenolic content of each sample was also determined and the infusion had the highest percentage of phenolics. To evaluate the antioxidant properties, the samples were tested by using DPPH” free radical scavenging, FRAP, and CUPRAC activity methods. The infusion showed the strongest radical scavenging activity, whereas n- hexane and chloroform extracts exhibited considerable reducing power effects. The MIC values for all of the examined microorganisms ranged from 15 to 2000 μg/mL with respect to antimicrobial activities.

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Composition and biological activities of Salvia veneris Hedge growing in Cyprus

Cited by 17 publications

References 48 publications

Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts

Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts

Extraction, Partial Identification and Bioactivities of Total Flavonoids from Carex meyeriana Kunth

Phytochemical Composition and Pharmacological Activities of Teucrium polium L. Collected from Eastern Turkey

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