Composition and Antiviral Activity of the Essential Oils of <i>Eryngium alpinum</i> and <i>E. amethystinum</i>

Dunkić, Valerija; Vuko, Elma; Bezić, Nada; Kremer, Dario; Ruščić, Mirko

doi:10.1002/cbdv.201300061

Cited by 34 publications

(38 citation statements)

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“…As an example, Dunkic et al [45] studied the essential oil of E. amethystinum from Croatia and reported sesquiterpene hydrocarbons (40.1%) as the most abundant compounds, followed by lower amounts of oxygenated sesquiterpenes (19.9%) and monoterpene hydrocarbons (15.2%). In this case, the major compound was (E)-caryophyllerne (19.7%), followed by a-pinene (12.3%), a-bisabolol (7.9%), 2,3,6-trimethylbenzaldehyde (7.9%), and germacrene D (7.2%).…”

Section: Chemical Composition Of Essential Oilsmentioning

confidence: 99%

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Cianfaglione

Blomme

Quassinti

et al. 2017

Chemistry & Biodiversity

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Eryngium campestre and E. amethystinum are thorny herbs belonging to the Apiaceae family and spontaneously growing in stony pastures and dry meadows, preferentially on calcareous substrates. In the Mediterranean countries, these plants have been used as a food or traditional remedies to treat various ailments. In the present work, we have analyzed the chemical composition of the essential oils distilled from the aerial parts by GC-FID and GC/MS, and evaluated their cytotoxic effects on a panel of human cancer cells, namely A375 (human malignant melanoma), MDA-MB 231 cells (human breast adenocarcinoma), and HCT116 cells (human colon carcinoma), by the MTT assay. Furthermore, the Eryngium essential oils were evaluated for antioxidant and acetylcholinesterase (AChE) activities. The two essential oils were rich in sesquiterpene hydrocarbons, with germacrene D as the major compound, accompanied by allo-aromadendrene, β-elemene, spathulenol, and ledol. They turned out to be highly cytotoxic on the tumor cells, with IC values (1.65 - 5.32 and 1.57 - 2.99 μg/ml for E. amethystinum and E. campestre, respectively) comparable or close to those of the anticancer drug cisplatin. The E. amethystinum essential oil exhibited a moderate antioxidant activity, whereas that of E. campestre a weak AChE inhibition.

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Section: Chemical Composition Of Essential Oilsmentioning

confidence: 99%

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Cianfaglione

Blomme

Quassinti

et al. 2017

Chemistry & Biodiversity

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“…Due to the inaccessibility of the material for the phytochemical research, these plants have been examined to a small extent. The presence of several phenolic acids-chlorogenic acid, rosmarinic acid, and its derivative-R-(+)-3′Oβ-d-glucopyranosyl rosmarinic acid (Le Claire et al 2005) and flavonoids-quercetin and kaempferol (Crowden et al 1969), and the essential oil (Dunkic et al 2013) was detected in the organs of ground plant. The main phenolic compounds estimated in the methanolic extract of shoots were-3,4-dihydroxyphenylacetic acid, chlorogenic and isochlorogenic acids, rosmarinic acid, as well as isoquercetin (Kikowska et al 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The main phenolic compounds estimated in the methanolic extract of shoots were-3,4-dihydroxyphenylacetic acid, chlorogenic and isochlorogenic acids, rosmarinic acid, as well as isoquercetin (Kikowska et al 2019). Moreover, the major constituents identified by GC-FID and GC/MS in the essential oil of E. alpinum isolated by hydrodistillation of the aerial parts of the plant were caryophyllene oxide (21.6%) and α-bisabolol from oxygenated sesquiterpenes (7.8%) as well as bicyclogermecrene (11.8%) and germacrene D (10.3%) (Dunkic et al 2013). The crude extract of roots rich in phenolic acids determined by HPLC-DAD demonstrated the antioxidant activity (Le Claire et al 2005) and the essential oil of the aerial parts showed the antiphytoviral effect (Dunkic et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Accumulation of valuable secondary metabolites: phenolic acids and flavonoids in different in vitro systems of shoot cultures of the endangered plant species—Eryngium alpinum L.

Kikowska

Thiem

Szopa

et al. 2020

Plant Cell Tiss Organ Cult

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In vitro cultures give the opportunity to perform the phytochemical studies on the protected species without harvesting the plant material from the natural environment. Shoots of Eryngium alpinum L. were multiplied on Murashige and Skoog (MS) medium in various systems, namely on the solid media and in two liquid cultures-stationary and agitated, as well as via regeneration from callus. The biomass increments were closely correlated with the number of shoots arising from one explant, which was connected with the supplementation of the culture media with the studied plant growth regulators. The methanolic extracts from shoots grown in the tested systems were subjected to phenolic acids and flavonoids qualitative and quantitative analysis. Biomass from in vitro shoot cultures accumulated from 19.59 to 32.95 times more phenolic acids [the total content ranged from 272.52 to 458.38 mg/100 g dry weight (DW)] and from 3.02 to 4.43 times more flavonoids (the total content ranged from 100.03 to 146.98 mg/100 g DW), depending on the culture system, than the extracts from basal leaves from the intact plant (13.91 and 33.16 mg/100 g DW, respectively). The phenolics present in shoot cultures include seven phenolic acids-3,4-dihydroxyphenylacetic, caftaric, caffeic, neochlorogenic, chlorogenic, isochlorogenic, and rosmarinic acids, and three flavonoids-isoquercetin, quercitrin and robinin. The best system for shoot proliferation resulting in the highest biomass growth and phenolic acids and flavonoids accumulation was solid culture on MS medium with BAP, IAA, and GA 3 (each 1.0 mg/l). The aim of this work was to check the effect of various culture systems (stationary and agitated, on solidified and in liquid media) on the production of phenolic compounds in E. alpinum shoots cultured in vitro. Key messageThis is the first report on phenolic acids and flavonoids estimation in Eryngium alpinum in vitro biomass from different culture systems.Keywords Alpine eryngo · Shoot multiplication · Phenolic acids · Flavonoids · HPLC-DAD analysis 1995). Some of the individuals are threatened by humansthe plant is collected for ornamental and commercial use and

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“…Due to the unavailability of the plant material, little research on this taxon was carried out. Only a few papers indicated the presence of phenolic acids, flavonoids and the essential oil in the organs of in vivo plants [3][4][5][6][7]. The identification of flavonoids, namely quercetin and kaempferol, in leaves of alpine eryngo was described by Crowden et al [3].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Acanthamoebic Activity of Shoots from in Vitro Cultures and in Vivo Plants of Eryngium alpinum L.—The Endangered and Protected Species

et al. 2020

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Genetically uniform shoots of Eryngium alpinum L. cultured in vitro were subjected to the qualitative analysis applying the UPLC-HESI-HRMS technique. In vitro cultures give the opportunity to perform the phytochemical studies on the protected species without harvesting the plant material from the natural environment. The phytochemical screening of the crude methanolic extracts of shoots, both from in vitro cultures and in vivo plants, revealed the presence of phenolic acids, coumarins, flavonoids, triterpenoid saponins, amino acids, or dipeptides. Active compounds detected are known to have medicinal importance, and for this reason, the present study represents a preliminary investigation of the extracts against pathogenic and opportunistic amoeba. Among the extracts tested, the extract of shoots from in vitro cultures exhibited remarkable amoebicidal action against trophozoites. On the second day of treatment, the extract at the concentrations of 5 mg/mL, 2.5 mg/mL, and 0.5 mg/mL showed the highest antiamoebicidal effect: the inhibition of trophozoites reached 81.14%, 66.38%, and 54.99%, respectively. To our best knowledge, the present report is the first to show the phytochemical screening and to discuss the antiamoebic activity of Eryngium alpinum L. shoots, both from in vitro cultures and in vivo plants.

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Composition and Antiviral Activity of the Essential Oils of Eryngium alpinum and E. amethystinum

Cited by 34 publications

References 46 publications

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Accumulation of valuable secondary metabolites: phenolic acids and flavonoids in different in vitro systems of shoot cultures of the endangered plant species—Eryngium alpinum L.

Phytochemical Screening and Acanthamoebic Activity of Shoots from in Vitro Cultures and in Vivo Plants of Eryngium alpinum L.—The Endangered and Protected Species

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