Composition and Antioxidant, Anticholinesterase, and Antibacterial Activities of the Essential Oil of Salvia buchananii from Algeria

Beladjila, Khadidja Aya; Berrehal, Djemaa; Al‐Aboudi, Amal; Semra, Z; Al‐Jaber, Hala I.; Bachari, Khaldoun; Kabouche, Zahia

doi:10.1007/s10600-018-2414-z

Cited by 3 publications

(7 citation statements)

References 19 publications

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“…Although, this is the first report on the anticholinesterase activity of Salvia microphylla. From literature reports, essential oils of other species from the genus Salvia also exhibited a notable inhibition of AChE [5,16,17,[64][65][66][67]. Some studies have demonstrated that AChE enzyme inhibitory effect of essential oil derived from poor camphor containing Salvia officinalis was lower than essential oils rich in camphor content [15,65].…”

Section: Anticholinesterase Activitymentioning

confidence: 99%

“…Nearly, 23 Salvia species cultivated in Algeria, among which S. buchananii, S. jaminiana, S. verbenaca subsp., S. clandestina, S. barrilieri, S. argentea subsp. and S. algeriensis Desf., were the subject of various studies [3][4][5]. Several species of Salvia have been applied as medicinal plants and used, among others, for enhancing memory functions and treatment of simple brain disorders [6], but also, to treat microbial infections, inflammation, malaria, cancer, and to disinfect homes after sickness [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Several species of Salvia have been applied as medicinal plants and used, among others, for enhancing memory functions and treatment of simple brain disorders [6], but also, to treat microbial infections, inflammation, malaria, cancer, and to disinfect homes after sickness [7,8]. The chemical composition of essential oil of Salvia species was reported in many review papers [5,[9][10][11][12][13][14][15][16][17]. The most important compounds of this essential oil are monoterpenes such as α-Pinene, β-Pinene, camphor, 1.8-cineole and borneol; and sesquiterpenes like β-Caryophyllene, germacrene D, Caryophyllene oxide.…”

Section: Introductionmentioning

confidence: 99%

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GC-MS Analysis and Biological Activities of Algerian Salvia microphylla Essential Oils

et al. 2021

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Abstract. Salvia microphylla is a known species due to its broad uses in traditional medicine against memory loss and rheumatism. The knowledge regarding the chemical composition and biological activities of the species collected in Algeria, no studies have been reported in the literature. Therefore, the present work focuses on the characterization of the chemical composition of the essential oils (EOs) and the determination of the antioxidant, anticholinesterase, α-glucosidase, and antimicrobial activities of Salvia microphylla. The EOs were obtained by hydrodistillation from the aerial parts, leaves and stems and submitted to chemical analysis by GC and GC/MS. The β-Caryophyllene was identified as the main constituent in the aerial parts and leaves essential oils with 16.75 ± 0.02 % and 17.86 ± 0.07 %, respectively. Likewise, the α-Eudesmol was the predominant component in the stems oil with (21.47 ± 0.20 %). The antioxidant activity of EOs was estimated through using four comparative methods: DPPH, ABTS•+, Reducing power and CUPRAC assays. The Stems oil was the most active one in CUPRAC assay, with an IC50 value with 7.72 ± 0.43 µg/mL. The enzyme inhibitory activity of the essential oils was realized against key enzymes involved in type 2 diabetes (α-glucosidase) using 4-Nitrophenyl-α-d-glucopyranoside as substrate and in neurodegenerative (AChE and BChE) diseases. The highest anticholinesterase activity against acetylcholinesterase was observed in the EO of aerial parts essential (IC50: 23.65 ± 0.73 µg/mL). The EO isolated from stems (IC50: 37.07 ± 1.44 µg/mL) exhibited a butyrylcholinesterase activity very close to that of analytical standard galantamine (IC50: 34.75 ± 1.99 µg/mL). Furthermore, all EOs displayed high inhibitory activity against α-glucosidase, better to that of the standard acarbose. The EOs of Salvia microphylla display potential properties against type 2 diabetes. A broth microdilution method was used to evaluate the antimicrobial activity of Salvia microphylla EOs, against eleven microbial strains and two yeast. The EOs showed better antibacterial activity against Gram-positive and Gram-negative bacteria except for Pseudomonas aeruginosa, with the stems essential oil being more efficient. Moreover, significant antifungal activity was observed against Candida albicans. Resumen. Salvia microphylla es una specie conocida debido a su amplio uso en medicina tradicional, contra la pérdida de memoria y el reumatismo. En el caso de la especie de planta recolectada en Algeria, no hay datos publicados sobre su composición química y sus actividades biológicas. Por ello, el presente trabajo ha sido enfocado en la caracterización de la composición química de aceites esenciales (EOs) de Salvia microphylla y en la determinación de sus actividades antioxidante, anticolinesterasa, α-glucosidasa y antimicrobiano. Los EOs fueron obtenidos mediante hidrodestilación de las partes aéreas, ojas y tallos, y fueron sometidos al análisis por cromatografía de gases con detección por ionización en flama y por espectrometría de masas. Se identificó a β-cariofileno como el componente principal de los aceites de las partes aéreas y de tallos con concentraciones de 16.75 ± 0.02 % y 17.86 ± 0.07 %, respectivamente. Por su parte, el α-Eudesmol fue encontrado como componente predominante en aceite de tallos (21.47 ± 0.20 %). La actividad antioxidante de los EOs fue estimada en base a cuatro métodos compartivos: DPPH, ABTS•+, poder reductor y ensayo CUPRAC. El aceite de tallos resultó ser el más activo en ensayo CUPRAC, con el valor IC50 de 7.72 ± 0.43 µg/mL. La actividad inhibitora de enzimas de los EOs fue evaluada contra principales enzimas involucrados en diabetes tipo 2 (α-glucosidasa), utilizando 4-Nitrofenil-α-d-glucopiranosida como sustrato, y en enfermedades neurodergenerativas (AChE y BChE). La mayor actividad anticolinesterasa y acetilcolinesterasa fue observada en el EO de partes aéreas (IC50: 23.65 ± 0.73 µg/mL). El EO islado de tallos (IC50: 37.07 ± 1.44 µg/mL) presentó actividad de butirilcolinestarasa muy similar a la del estándar analítico, galantamina (IC50: 34.75 ± 1.99 µg/mL). Aunado a ello, todos EOs presentaron una alta actividad inhibitora contra α-glucosidasa, que era mejor comparando con la del estándar de acarbosa. Los EOs de Salvia microphylla presentan potenciales propiedades contra diabetes tipo 2. Para evaluar la actividad antimicrobiana de los EOs de Salvia microphylla, se utilizó el método de microdulución en caldo, contra once sepas microbianas y dos de levadura. La mejor actividad se observó contra bacterias Gram-positivas y Gram-negativas, excepto Pseudomonas aeruginosa, los cuales presentaron alta resistencia. Los EOs presentaron también importante actividad antifungica contra Candida albicans.

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Section: Anticholinesterase Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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GC-MS Analysis and Biological Activities of Algerian Salvia microphylla Essential Oils

et al. 2021

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“…Some species show high values of caryophyllene and caryophyllene oxide such as S. hispanica, Turkish S. trichoclada and S. multicaulis, S. montbretii, Iranian S. virgata , S. reuteriana and S. multicaulis , Iranian S. nemorosa and Turkish cultivated S. forskahlei . A lot of species have 1,8‐cineole as main component such as S. fruticosa, S. lavandulifolia, S. buchananii, S. bucharica, S. palaestina, S. ringens and S. veneris from Italy . Figure shows a cultivation of sage in Sicily, and a particular of its inflorescence.…”

Section: Essential Oils: Very Old ‘Guys’ With Great Prospectsmentioning

confidence: 99%

“…[127] A lot of species have 1,8cineole as main component such as S. fruticosa, S. lavandulifolia, S. buchananii, S. bucharica, S. palaestina, S. ringens and S. veneris from Italy. [103,109,123,124,134,135,140] Figure 7 shows a cultivation of sage in Sicily, and a particular of its inflorescence.…”

Section: Rosemarymentioning

confidence: 99%

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Napoli

Siracusa

Ruberto

2020

Chemistry & Biodiversity

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Lamiaceae is one of the largest families of flowering plants comprising about 250 genera and over 7,000 species. Most of the plants of this family are aromatic and therefore important source of essential oils. Lamiaceae are widely used as culinary herbs and reported as medicinal plants in several folk traditions. In the Mediterranean area oregano, sage, rosemary, thyme and lavender stand out for geographical diffusion and variety of uses. The aim of this review is to provide recent data dealing with the phytochemical and pharmacological studies, and the more recent applications of the essential oils and the non‐volatile phytocomplexes. This literature survey suggests how the deeper understanding of biomolecular processes in the health and food sectors as per as pest control bioremediation of cultural heritage, or interaction with human microbiome, fields, leads to the rediscovery and new potential applications of well‐known plants.

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A Review on the Ethnopharmacology and Phytochemistry of the Neotropical Sages (Salvia Subgenus Calosphace; Lamiaceae) Emphasizing Mexican Species

et al. 2022

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Salvia is the most diverse genus within the mint family (Lamiaceae), many of its species are well-known due to their medicinal and culinary uses. Most of the ethnopharmacological and phytochemical studies on Salvia are centred on species from the European and Asian clades. However, studies about the most diverse clade, the Neotropical sages (Salvia subgenus Calosphace; 587 spp.), are relatively scarce. This review aims to compile the information on the traditional medicinal uses, pharmacological and phytochemistry properties of the Neotropical sages. To do so, we carried out a comprehensive review of the articles available in different online databases published from the past to 2022 (i.e., PubMed, Scopus, and Web of Science, among others) and summarized the information in tables. To uncover phylogenetic patterns in the distribution of four different groups of metabolites (mono-, sesqui-, di-, and triterpenes), we generated presence-absence matrices and plotted the tip states over a dated phylogeny of Salvia. We found several studies involving Mexican species of Salvia, but only a few about taxa from other diversity centres. The main traditional uses of the Mexican species of Calosphace are medicinal and ceremonial. In traditional medicine 56 species are used to treat diseases from 17 categories according to the WHO, plus cultural-bound syndromes. Pharmacological studies reveal a wide range of biological properties (e.g., antinociceptive, anti-inflammatory, anxiolytic, cytotoxic, and antidiabetic, etc.) found in extracts and isolated compounds of 38 Neotropical sages. From extracts of these species, at least 109 compounds have been isolated, identified and evaluated pharmacologically; 73 of these compounds are clerodanes, 21 abietanes, six flavonoids, five sesquiterpenoids, and four triterpenoids. The most characteristic metabolites found in the Neotropical sages are the diterpenes, particularly clerodanes (e.g., Amarisolide A, Tilifodiolide), that are found almost exclusively in this group. The Neotropical sages are a promising resource in the production of herbal medication, but studies that corroborate the properties that have been attributed to them in traditional medicine are scarce. Research of these metabolites guided by the phylogenies is recommended, since closely related species tend to share the presence of similar compounds and thus similar medicinal properties.

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Composition and Antioxidant, Anticholinesterase, and Antibacterial Activities of the Essential Oil of Salvia buchananii from Algeria

Cited by 3 publications

References 19 publications

GC-MS Analysis and Biological Activities of Algerian Salvia microphylla Essential Oils

GC-MS Analysis and Biological Activities of Algerian Salvia microphylla Essential Oils

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

A Review on the Ethnopharmacology and Phytochemistry of the Neotropical Sages (Salvia Subgenus Calosphace; Lamiaceae) Emphasizing Mexican Species

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