Composites

Gupta, Tanmay; Kumawat, Vijay Shankar; Ghosh, Subrata Bandhu; Bandyopadhyay‐Ghosh, Sanchita; Sain, Mohini

doi:10.1002/9781119767480.ch16

Cited by 4 publications

(2 citation statements)

References 390 publications

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“…Despite their distinct advantages, controlling the shape and microarchitecture (including porosity) through conventional ceramic fabrication is extremely difficult. Furthermore, techniques, such as salt leaching, gas foaming, and polymer templating, developed to enhance the scaffold porosity fail to provide sufficient control in the pore size, their distribution and interconnectivity; and lack reproducibility [43][44][45][46][47][48][49][50][51][52].…”

Section: Introductionmentioning

confidence: 99%

Is it possible to 3D bioprint load-bearing bone implants? A critical review

Gupta,

Ghosh,

Bandyopadhyay-Ghosh

et al. 2023

Biofabrication

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Rehabilitative capabilities of any tissue engineered scaffold rely primarily on the triad of i) biomechanical properties such as mechanical properties and architecture, ii) chemical behaviour such as regulation of cytokine expression, and iii) cellular response modulation (including their recruitment and differentiation). The closer the implant can mimic the native tissue, the better it can rehabilitate the damage therein. Among the available fabrication techniques, only 3D bioprinting (3DBP) can satisfactorily replicate the inherent heterogeneity of the host tissue. However, 3DBP scaffolds typically suffer from poor mechanical properties, thereby, driving the increased research interest in development of load-bearing 3DBP orthopaedic scaffolds in recent years. Typically, these scaffolds involve multi-material 3D printing, comprising of at-least one bioink and a load-bearing ink; such that mechanical and biological requirements of the biomaterials are decoupled. Ensuring high cellular survivability and good mechanical properties is a key concern in all these studies. 3DBP of such scaffolds is in early developmental stages, and research data from only a handful of preliminary animal studies are available, owing to limitations in print-capabilities and restrictive materials library. This article presents a topically focused review of the state-of-the-art, while highlighting aspects like available 3DBP techniques; biomaterials’ printability; mechanical and degradation behaviour; and their overall bone-tissue rehabilitative efficacy. This collection amalgamates and critically analyses the research aimed at 3DBP of load-bearing scaffolds for fulfilling demands of personalized-medicine. We highlight the recent-advances in 3DBP techniques employing thermoplastics and phosphate-cements for load-bearing applications. Finally, we provide an outlook for possible future perspectives of 3DBP for load-bearing orthopaedic applications. Overall, the article creates ample foundation for future research, as it gathers the latest and ongoing research that scientists could utilize.

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Section: Introductionmentioning

confidence: 99%

Is it possible to 3D bioprint load-bearing bone implants? A critical review

Gupta,

Ghosh,

Bandyopadhyay-Ghosh

et al. 2023

Biofabrication

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“…Overall, a nanocomposite conductive hydrogel exhibited excellent static and dynamic mechanical performance, considerable electrical conductivity, significant electrical response to applied external stress, and stability in phosphate-buffered saline (PBS), which laid the foundation for its application as a flexible biosensor. 73 Preparation of Conductive Hydrogels. Preparation of Multifunctional Hydrogels.…”

Section: ■ Introductionmentioning

confidence: 99%

Conductive Hydrogels—A Novel Material: Recent Advances and Future Perspectives

Liu

Wei

Song

et al. 2020

J. Agric. Food Chem.

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A conductive hydrogel is a kind of polymer material having substantial potential applications with various properties, including high toughness, self-recoverability, electrical conductivity, transparency, freezing resistance, stimuli responsiveness, stretchability, self-healing, and strain sensitivity. Herein, according to the current research status of conductive hydrogels, properties of conductive hydrogels, preparation methods of different conductive hydrogels, and their application in different fields, such as sensor and actuator fabrication, biomedicine, and soft electronics, are introduced. Furthermore, the development direction and application prospects of conductive hydrogels are proposed.

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