Composite wound dressing for drug release

Purwar, Roli; Rajput, Poonam; Srivastava, Chitra

doi:10.1007/s12221-014-1422-2

Cited by 21 publications

(13 citation statements)

References 16 publications

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“…It allows the drug compound in the film to have sustained-release into wound site. This finding is supported by the study of Purwar et al, [43] and Sarheed et al [44]; releasing of BSA drug from composite hydrogel and metronidazole drug from alginate hydrogel were attributed to swelling behavior of dressing.…”

Section: Discussionsupporting

confidence: 64%

Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

Tan

Arulselvan

et al. 2020

BioMed Research International

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Chronic wounds represent serious globally health care and economic issues especially for patients with hyperglycemic condition. Wound dressings have a predominant function in wound treatment; however, the dressings for the long-lasting and non-healing wounds are still a significant challenge in the wound care management market. Astonishingly, advanced wound dressing which is embedded with a synthetic drug compound in a natural polymer compound that acts as drug release carrier has brought about promising treatment effect toward injured wound. In the current study, results have shown that Vicenin-2 (VCN-2) compound in low concentration significantly enhanced cell proliferation and migration of HDF. It also regulated the production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α from HDF in wound repair. Treatment of VCN-2 also has facilitated the expression of TGF-1β and VEGF wound healing maker in a dose-dependent manner. A hydrocolloid film based on sodium alginate (SA) incorporated with VCN-2 synthetic compound which targets to promote wound healing particularly in diabetic condition was successfully developed and optimized for its physico-chemical properties. It was discovered that all the fabricated film formulations prepared were smooth, translucent, and good with flexibility. The thickness and weight of the formulations were also found to be uniform. The hydrophilic polymer comprised of VCN-2 were shown to possess desirable wound dressing properties and superior mechanical characteristics. The drug release profiles have revealed hydrocolloid film, which is able to control and sustain the VCN-2 released to wound area. In short, hydrocolloid films consisting of VCN-2 formulations are suitably used as a potential wound dressing to promote restoration of wound injury.

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Section: Discussionsupporting

confidence: 64%

Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

Tan

Arulselvan

et al. 2020

BioMed Research International

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“…The pH environment of chronic wounds had been recorded within the range of 7.1-8.9. As the wound progress toward healing the pH moves to neutral and then becomes acidic up to 5.4-5.6 [44,45]. It usually takes shorter time for wound healing in acidic environment than alkaline environment.…”

Section: Silver Ion Release In Vitromentioning

confidence: 99%

pH-responsive release behavior and anti-bacterial activity of bacterial cellulose-silver nanocomposites

Shao

Liu

et al. 2015

International Journal of Biological Macromolecules

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“…Silk woven fabric (thickness~0.20 mm) was cut into pieces (10 cm × 10 cm). These pieces were immersed in a solution of ammonium persulphate (APS) (25% w/v) for 24 h. The samples were thoroughly washed with distilled water and squeezed between two filter papers to remove any excess solution [17].…”

Section: Preparation Of Composite Wound Dressing Materialsmentioning

confidence: 99%

“…The grafting and crosslinking reaction were carried out in a beaker for 45 min at 60 • C. Samples were washed with water to extract homopolymer as well as unreacted monomers. The grafted samples were dried under vacuum until a constant weight was obtained [17].…”

Section: Hydrogel Grafting On Tasar Silk Fibroin Fabricmentioning

confidence: 99%

Zinc Oxide Nanoparticles Functionalized on Hydrogel Grafted Silk Fibroin Fabrics as Efficient Composite Dressing

et al. 2020

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Recent advances in woundcare is targeted towards developing active-dressings, where multiple components are combined to provide a suitable environment for rapid healing. The aim of the present research is to study the preparation of biomimic composite wound dressings by the grafting of hydrogel on silk fibroin fabric. The swelling ability of hydrogel grafted silk fibroin fabric was optimized by changing the initiator concentration. In order to impart antimicrobial properties, these dressing are further coated sono-chemically with zinc oxide nanoparticles. The water vapor transmission rate of the prepared samples was measured. The conformation of silk fibroin proteins after grafting with hydrogel was also confirmed using Fourier Transform Infrared Spectroscopy (FTIR). The morphology of the zinc oxide-coated silk fibroin fabric and hydrogel-coated silk fibroin was studied using Scanning Electron Microscope (SEM). The antimicrobial activity of the zinc oxide-coated samples was studied against E coli. The cytocompatibility of the prepared dressing materials were evaluated using L929 fibroblast cells. MTT assay and phase contrast microscopic studies showed that the adherence, growth, and proliferation of the L929 fibroblast cells that were seeded on zinc oxide nanoparticles on the functionalized hydrogel-coated silk fibroin dressing was significantly higher than that of pure silk fibroin due to the highly porous, bio-mimic structure that allowed ease of passage of nutrients, growth factors, metabolites, and the exchange of gases which is beneficial for successful regeneration of damaged tissues. The expression of TNF-α and IL-2 were not significantly higher than that of control. The proposed composite dressing would be a promising material for wound dressing and regenerative medicine but in order to prove the efficacy of these materials, more in vivo experiments and clinical tests are required to be conducted in future.

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Composite wound dressing for drug release

Cited by 21 publications

References 16 publications

Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

pH-responsive release behavior and anti-bacterial activity of bacterial cellulose-silver nanocomposites

Zinc Oxide Nanoparticles Functionalized on Hydrogel Grafted Silk Fibroin Fabrics as Efficient Composite Dressing

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