Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications

Abstract

An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds.

Trends in Surgical and Beauty Masks for a Cleaner Environment

“…As it appears from the reported immuno-histochemical study, the CD34-positive cells appear to be more expressed in skin treated by CN and CN-Lutein compared with the non-treated control (Figure 7). On the other hand, the interesting stimulus activity on CD-34-positive radicular-follicular (i.e., stem) cells reported from our group some years ago [78] has been confirmed recently from other research groups [79][80][81][82]. Thus, it has shown an increasing activity of anagen hair follicles of mice treated topically by chitosan and CN with a contemporary decrease in the number of catagen follicles, compared with the control group [82].…”

“…According to the Yudin group research studies [76], it has been supposed that CN "contributes to the orientation of the chitosan macromolecule that leads to an increased strength and elastic Young module of the composite fibers" as reported on Figure 8, contributing also to the degradability and sustainability of the nanocomposite processing [67,68,76,77]. The introduction of CN into the chitosan matrix could contribute to form a more bioresorbable composite, increasing its biocompatibility, bioactivity, hemocompatibility and effectiveness at the skin level [76,[79][80][81].…”

Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting

“…The antibacterial resistance of microorganisms, as a rule, is one of the main problems in the field of wound care and their treatment, which leads to complications such as infections and delayed healing [154]. An appropriate dressing ought to be capable of absorbing exudates from the wound area and this allows water to evaporate at a certain point, preventing microbial transport [155].…”

Bioactive Collagen Hydrolysate-Chitosan/Essential Oil Electrospun Nanofibers Designed for Medical Wound Dressings

“…Wound dressing materials are produced for wound healing process. The main techniques to obtain wound dressings include electrospinning [1][2][3][4][5][6][7][8][9], cryogelation [10], solvent casting [11], freezing-thawing [12,13], and dip coating [14] methods. Usually, wound dressings include films, bandages, hydrocolloids, fibers, foams, dermal patches, and sponges [15].…”