Composite Tissue Allotransplantation Immunology

Eun, Seok Chan

doi:10.5999/aps.2013.40.2.141

Cited by 18 publications

(26 citation statements)

References 94 publications

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“…Approximately 55% of post-transplantation infections are caused by bacteria or viruses, and 15% to 30% are caused by fungi. 3 The occurrence of infection depends on the patient's immune response and degree of immunosuppression. 4 HSCT is widely performed for the treatment of malignant blood disorders, including acute and chronic leukemia, aplastic anemia, myelodysplastic syndromes, severe combined immunodeficiency, lymphoma and some solid tumors, such as breast cancer.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

The need for endodontic treatment and systemic characteristics of hematopoietic stem cell transplantation patients

et al. 2017

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The aim of this study is to investigate the relationship between the epidemiological and clinical profiles of patients before and after hematopoietic stem cell transplantation (HSCT) and the need for endodontic treatment. The subjects included 188 individuals enrolled in the dental care program for transplanted patients of the School of Dentistry, Federal University of Minas Gerais (Faculdade de Odontologia da Universidade Federal de Minas Gerais, FO-UFMG) from March 2011 through March 2016. The patients were subjected to an HSCT conditioning dental regimen based on a thorough clinical and radiographic evaluation. Intraoral periapical and bite-wing X-rays were obtained, and after evaluation, specific dental treatment was planned and performed. The following demographic and clinical data were collected from the patients' medical records: age, gender, transplantation stage, primary disease, transplant type, medication used, complete blood count at the time of visit, and need for endodontic treatment. The Kolmogorov-Smirnov and the chi-square tests were used. Leukemia (31.3%) and multiple myeloma (17.9%) were the most prevalent primary diseases. Most patients were subjected to allogeneic-related transplantation (83.6%). Most patients exhibited platelet counts and hemoglobin concentrations below the reference values in the pre-transplantation stage, while the neutrophil and platelet counts and the hemoglobin levels were within the reference ranges in the post-transplantation stage. The proportions of individuals requiring endodontic treatment were similar between the pre-and post-transplantation groups: 24.3% and 24.7%, respectively. The systemic conditions of the patients referred for dental treatment were compromised.

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Section: Declaration Of Interestsmentioning

confidence: 99%

The need for endodontic treatment and systemic characteristics of hematopoietic stem cell transplantation patients

et al. 2017

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“…Some methods of antibody-mediated costimulatory blockade against CD28, CD80, CD154, and CD40 have been used in both animal and human studies to prevent graft rejection. Depending on the target and method and timing of application, antibody-mediated blockade has led to varying degrees of donor-specific hyporesponsiveness [80][81][82][83].…”

Section: Rejection and Antigen-presenting Cellsmentioning

confidence: 99%

“…This immunosuppressive cytokine is also involved in wound healing, collagen formation, and fibrosis. Intramuscular administration of adenoviral TGF-β1 in rat lung recipients led to increased serum protein levels with significant improvement of lung oxygenation [82,83]. Perfusion of murine donor hearts with liposomal DNA complexes containing active human TGF-β1 was found to result in prolonged allograft survival, an effect amplified by CD8 + T cell depletion [84].…”

Section: Cd4mentioning

confidence: 99%

Strategies for Gene Transfer to Vascularized Composite Allografts

Lough

Cooney

2015

The Science of Reconstructive Transplantation

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“…15,16 Transplant immunology is the most important area of research in VCA and many current studies are attempting to increase our knowledge of rejection mechanisms, routine immunosuppressive regimes, dosages and immune toleranceinducing strategies. The most widely accepted classification system is the Banff Classification.…”

Section: Nomenclaturementioning

confidence: 99%

“…15 Immunosuppressive therapy has well-documented side effects which may give rise to conditions that shorten life. Induction immunotherapy is used as a means to overcome the ischaemic injury and surgical trauma an allograft undergoes during the transplant process.…”

Section: Nomenclaturementioning

confidence: 99%