Composite Tissue Allotransplantation: Classification of Clinical Acute Skin Rejection

Abstract

Based on this survey, we proposed an initial classification system for acute rejection in the skin of a CTA and demonstrated that this system is easily reproduced by independent pathologists.

Differential Effects of HNF-1α Mutations Associated with Familial Young-Onset Diabetes on Target Gene Regulation

“…The slides were reviewed in a blinded fashion by two qualified pathologists to assess the quality of the graft and rejection. These were classified into four grades (grades 0-3) according to the modified scoring system for acute mouse skin allograft rejection proposed by Cendales et al (17). Grade 0 (nonspecific changes) is when little infiltration of inflammatory cells into the epidermis is observed.…”

Systematic pathological component scores for skin-containing vascularized composite allografts

“…5,[9][10][11] The classification has been clinically useful in the diagnosis of rejection, however, the need for characterization of the pathologic features and a better understanding of mechanisms remain. 12,13 The findings in this study highlight the potential usefulness of a systematic approach to evaluation of rejection in allograft biopsies where pathologic patterns may overlap or not meet qualitative characteristics.…”

Mesenchymal Stem Cells Enhance the Induction of Mixed Chimerism and Tolerance to Rat Hind-Limb Allografts after Bone Marrow Transplantation

“…In addition, biopsies were taken at the presence of clinical signs of rejection for assessment of the degree of rejection. Histopathological grading was done on routine hematoxylin-and-eosin stained sections according to previously published criteria [15]. Normal histopathological findings were accepted as grade 0.…”