Composite pullulan–dextran polysaccharide scaffold with interfacial polyelectrolyte complexation fibers: A platform with enhanced cell interaction and spatial distribution

Cutiongco, Marie F.A.; Tan, Ming; Ng, Martin Yoke Kuang; Visage, Catherine Le; Yim, Evelyn K.F.

doi:10.1016/j.actbio.2014.06.029

Cited by 40 publications

(17 citation statements)

References 34 publications

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“…Dextran is a biocompatible, biodegradable, non-immunogenic and non-antigenic biopolymer and hence it has been widely applied in various biomedical applications, such as drug delivery applications [12], as scaffolds for tissue engineering applications [13,14] and as molecular arms [15], etc. Scaffold materials made up of dextran were soft and flexible and hence it improves the handling efficiency for the management of wound treatment [16].…”

Section: Q2mentioning

confidence: 99%

Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing

Unnithan

Sasikala

Murugesan

et al. 2015

International Journal of Biological Macromolecules

122

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Section: Q2mentioning

confidence: 99%

Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing

Unnithan

Sasikala

Murugesan

et al. 2015

International Journal of Biological Macromolecules

122

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“…Then, Wan et al . developed the single‐interface drawing to multi‐interface drawing, which can incorporate several components into PEC fiber . Wang and coworkers also prepared multi‐colored PEC fibers by assembling DNA or histone protein with cationic conjugated polymers .…”

Section: Background and Originality Contentmentioning

confidence: 99%

A Salt Controlled Scalable Approach for Formation of Polyelectrolyte Complex Fiber^†

et al. 2020

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of main observation and conclusion A new scalable approach is reported here for producing the polyelectrolyte complex (PEC) fiber of alginate (ALG) and poly(diallyldimethylammonium chloride) (PDDA). Salt (LiBr, NaBr, or KBr) is used to restrict the complexation of negatively charged ALG and positively charged PDDA in solution to obtain spinnable fluid that can be directly extruded into the coagulation bath to form nascent fiber. A water washing step is adopted right after the formation of nascent fiber to eliminate the defects in fiber. Morphology and mechanical properties of the as-prepared ALG/PDDA complex fiber are found to be greatly affected by the water washing, as well as the amount and the type of salt used. As the reported approach is similar to the wet-spinning process which is a commonly used method for industrial production of fibers, it is promising to be applied in larger scale production of PEC fibers.www.cjc.wiley-vch.de

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“…Polysaccharides are hydrophilic, biocompatible, biodegradable, non-immunogenic and non-antigenic. In addition to being safe and stable, these materials have functional groups such as carboxyl, hydroxyl and amino groups, which can be physically or chemically modified to achieve a wide range of properties that may be adapted according to specific needs [12,14,15]. Among the various polysaccharides, dextran (DEX) stands out as a bacterial polyanionic carbohydrate that has low protein adsorption and is non-toxic, highly soluble in water, biocompatibility and consists of linear 1,6-glucopyranose units linked with a certain degree of 1,3-branching, found in different molecular weights forming hydrogels [12,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility

Campos

Ferrari

Cassimiro

et al. 2015

J Therm Anal Calorim

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Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly watersoluble drugs has become an important issue for analysis in pharmaceutical research. The use of dextran hydrogels is an advantageous strategy and the focus of extensive research. In this study, several hydrogels were developed from homologous polymer blends using 70 and 148 kDa dextrans in different proportions containing praziquantel, with the aim of evaluating the effects of polymeric release systems on the solubility of poorly water-soluble drugs such as praziquantel. Nine formulations were prepared, and the solubility of the drug incorporated was assessed. Three of the formations were selected to be characterized by DSC for the study in order to gain a better understanding of the thermal behavior of praziquantel incorporated into dextran hydrogels and the influence of polymers on the solubility of the drug, complemented by XRD and SEM techniques. According to the results, formation of crystallites of praziquantel occurred, probably due to the preparation procedures of the formulations, covering the surface of the polymer matrix and promoting a slight improvement in solubility.These data show that the use of hydrogels for the purposes of improving the solubility of poorly water-soluble drugs represents an effective strategy.

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Composite pullulan–dextran polysaccharide scaffold with interfacial polyelectrolyte complexation fibers: A platform with enhanced cell interaction and spatial distribution

Cited by 40 publications

References 34 publications

Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing

Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing

A Salt Controlled Scalable Approach for Formation of Polyelectrolyte Complex Fiber^†

Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility

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Composite pullulan–dextran polysaccharide scaffold with interfacial polyelectrolyte complexation fibers: A platform with enhanced cell interaction and spatial distribution

Cited by 40 publications

References 34 publications

Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing

Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing

A Salt Controlled Scalable Approach for Formation of Polyelectrolyte Complex Fiber†

Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility

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Product

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A Salt Controlled Scalable Approach for Formation of Polyelectrolyte Complex Fiber^†