Composite Polymer Colloids for SERS‐Based Applications

Strozyk, Malte S.; Aberasturi, Dorleta Jiménez de; Liz‐Marzán, Luis M.

doi:10.1002/tcr.201700082

Cited by 24 publications

(23 citation statements)

References 68 publications

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“…The optical properties of a SERS‐active substrate are greatly affected by its micromorphology . This influence is even more evident in those substrates that have complicated or composite structures . In this paper, AuNS was utilized to construct a SERS‐active substrate with AuNP/NS composite structure.…”

Section: Resultsmentioning

confidence: 99%

Direct Synthesis of Gold Nanoparticle‐Over‐Nanosheet for Sensitive SERS Detection

Chen

Jin

Zhu

et al. 2018

Part & Part Syst Charact

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A simple ethanol sol‐based method for the synthesis of gold nanosheets (AuNSs) and gold nanoparticle‐over‐nanosheet (AuNP/NS) is developed. Gold nanoparticles (AuNPs) with average sizes of ≈8 nm are grown in situ on the surface of the AuNS, which forms a NP/NS structure that obtains strong, significantly improved, surface‐enhanced Raman spectroscopy activity with the magnitude ≈2 and ≈6 orders higher than the simplex AuNP and AuNS, respectively. This performance is mainly attributed to uniform AuNPs that are closely packed over AuNS and coupled with NP–NS and NP–NP interactions. The NP–NS–GP (the gap between NP–NS) is narrower than NP–NP–GP in which much stronger and steadier plasmon resonance is obtained that can significantly enhance the Raman signal. The results show that single‐crystalline AuNS is an ideal substrate, which can be further coated with other metallic NPs to form a new flexible, high‐activity and AuNS‐based nanocomposite for a wide variety of applications.

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Section: Resultsmentioning

confidence: 99%

Direct Synthesis of Gold Nanoparticle‐Over‐Nanosheet for Sensitive SERS Detection

Chen

Jin

Zhu

et al. 2018

Part & Part Syst Charact

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“…SERS nanoparticles combined with reporter molecules are often precipitate or aggregate in biological fluids with high ionic strength (Lane, Qian, & Nie, 2015). Moreover, the competitive adsorption of the abundant proteins to Raman report molecules would take place in the biological environment, and lead to the quenching of SERS signal (Strozyk, Jimenez de Aberasturi, & Liz‐Marzan, 2018). Therefore, proper antifouling surface coatings are necessary for improving the biological stability and safety of SERS nanoparticles, thus expanding their SERS related application in vivo.…”

Section: Sers Nanoparticlesmentioning

confidence: 99%

Recent advances in applications of nanoparticles in SERS in vivo imaging

et al. 2020

WIREs Nanomed Nanobiotechnol

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Surface‐enhanced Raman scattering (SERS) technique has been regarded as one of the most important research methods in the field of single‐molecule science. Since the previous decade, the application of nanoparticles for in vivo SERS imaging becomes the focus of research. To enhance the performance of SERS imaging, researchers have developed several SERS nanotags such as gold nanostars, copper‐based nanomaterials, semiconducting quantum dots, and so on. The development of Raman equipment is also necessary owing to the current limitations. This review describes the recent advances of SERS nanoparticles and their applications for in vivo imaging in detail. Specific examples highlighting the in vivo cancer imaging and treatment application of SERS nanoparticles. A perspective on the challenges and opportunities of nanoparticles in SERS in vivo imaging is also provided. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…This effect also results from the interaction of the electromagnetic radiation with the Au NPs, resulting in the local enhancement of the electric field in specific sites (hot spots), such as metal nanojunctions. Thus, the polarization of molecules adsorbed at the surface of the NP are also affected resulting in an enhancement of the Raman scattering signal, allowing the identification of such molecular species even in very diluted conditions [140,141,142]. The importance of polymer/Au nanocomposites in the preparation of these diagnosis platforms also results from the colloidal stabilization and chemical functionalization conferred by the polymer shells, namely when they are intended to be used in complex environments such as real biological samples [141,142,143] RAFT-polymer/Au nanocomposites have been prepared aiming the preparation of nanoassemblies, in which the NPs become close to each other, thus creating “hot spots” that result in improved SERS signals [144].…”

Section: Au Nps In Opto-biodetection and Beyondmentioning

confidence: 99%

Polymer@gold Nanoparticles Prepared via RAFT Polymerization for Opto-Biodetection

2018

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Colloidal gold nanoparticles (Au NPs) have been used in several biological applications, which include the exploitation of size-and shape-dependent Localized Surface Plasmon Resonance (LSPR) in biosensing devices. In order to obtain functional and stable Au NPs in a physiological medium, surface modification and functionalization are crucial steps in these endeavors. Reversible addition-fragmentation chain transfer (RAFT) polymerization meets this need offering the possibility of control over the composition and architecture of polymeric shells coating Au NPs. Furthermore, playing with a careful choice of monomers, RAFT polymerization allows the possibility to design a polymer shell with the desired functional groups aiming at Au based nanocomposites suitable for biorecognition and biotargeting. This review provides important aspects concerning the synthesis and optical properties of Au NPs as well as concepts of RAFT polymerization. Understanding these concepts is crucial to appreciate the chemical strategies available towards RAFT-polymer coated Au core-shell nanostructures, which are here reviewed. Finally, examples of applications in opto-biodetection devices are provided and the potential of responsive "smart" nanomaterials based on such structures can be applied to other biological applications.

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Composite Polymer Colloids for SERS‐Based Applications

Cited by 24 publications

References 68 publications

Direct Synthesis of Gold Nanoparticle‐Over‐Nanosheet for Sensitive SERS Detection

Direct Synthesis of Gold Nanoparticle‐Over‐Nanosheet for Sensitive SERS Detection

Recent advances in applications of nanoparticles in SERS in vivo imaging

Polymer@gold Nanoparticles Prepared via RAFT Polymerization for Opto-Biodetection

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