In the last decade, consistent and successful innovations have been achieved in the field of lasers and optics, collectively known as ‘photonics’, founding new applications in biomedicine, including clinical biopsy. Non-invasive photonics-based diagnostic modalities are rapidly expanding, and with their exponential improvement, there is a great potential to develop practical instrumentation for automatic detection and identification of different types and/or sub-types of diseases at a very early stage. While using conventional light for the studies of different properties of objects in materials science, astrophysics and biomedicine already has a long history, the interaction of polarized light and optical angular momentum with turbid tissue-like scattering media has not yet been ultimately explored. Since recently this research area became a hot topic. This feature issue is a first attempt to summarize the recognitions achieved in this emerging research field of polarized light and optical angular momentum for practical biomedical applications during the last years.