Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

Abstract

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

Development of a Zeolite/Polymer‐Based Hydrogel Composite through Photopolymerization for 3D Printing Application

“…However, hydrogel materials have some defects, such as low mechanical properties and poor toughness. To improve the property and function of hydrogel, different fillers are studied to be combined with hydrogels, [7,11] including zeolites, [12,13] silica (SiO 2 ), [14] carbon nanotubes, [15] iron trioxide (Fe 2 O 3 ), [16] cellulose nanofibrils, [17] fibers, [18] etc.…”

“…As a class of aluminosilicates, zeolites have a large amount of micropores and large specific surface area. [ 19 ] Therefore, zeolites have good adsorption performance, and are widely used in various applications, such as drug delivery [ 12 ] and adsorption. In recent years, more and more works have reported about the combination of zeolite as filler and polymers to produce composites or hydrogel composites.…”

“…al. [ 12 ] used poly(ethylene glycol) diacrylate (PEGDA) and clinoptilolite particles (natural zeolite) to obtain composites nanogels. These composites had tunable drug‐loading capability, swelling behavior, and cytotoxicity, which could be applied as drug reservoirs.…”

Photopolymerization of Zeolite Filler‐Based Composites for Potential 3D Printing Application and Gas Adsorption Applications

“…These molecular sieves have a lot of applications as catalysts in petrochemical industry and environmental protection for example. [34][35][36] In recent years, more and more researchers are working to combine zeolite as fillers with polymers to produce composites or hydrogel composites applied in medicine industry, [37,38] adsorption and separation industry. [39,40] Zhang et.…”

“…3D printing, an additive manufacturing (AM) technique, recently has been developed in many fields, such as electronic industry, [1,2] adsorption and separation industry, [3,4] biomedicine industry, [5][6][7] and etc. As the most common materials, polymers applied in medicine industry, [37,38] adsorption, and separation industry. [39,40] Zhang et.…”