Composite magnetic microspheres: Preparation and characterization

Zhang, Ji; Zhang, Shengtang; Ruan, Roger; Zeng, Jiayu

doi:10.1016/j.jmmm.2006.06.035

Cited by 27 publications

(14 citation statements)

References 15 publications

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“…Their results showed that composite From the hysteresis loops of CMMS (Figure 3), the saturation magnetization was 8.065 emu/g, coercivity was 76.05 Oe and retentivity was 1.057 emu/g. These results are in agreement with Zhanga Ji et al the magnetic properties of the composite magnetic microspheres were evaluated using a VSM [27].…”

Section: Results and Discusssionsupporting

confidence: 90%

“…Erika Aranas et al [26] prepared the spheres with technique similar to emulsion polymerization. Zhanga Ji et al prepared composite magnetic microspheres based on artemisia seed gum and chitosan using the suspension cross-linking technique for use in the application of magnetic carrier technology [27]. Their results showed that composite From the hysteresis loops of CMMS (Figure 3), the saturation magnetization was 8.065 emu/g, coercivity was 76.05 Oe and retentivity was 1.057 emu/g.…”

Section: Results and Discusssionmentioning

confidence: 99%

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Preparation of biocompatible magnetic microspheres with chitosan

Nasra¹,

Mohamed²,

Elblbesy³

et al. 2011

JBNB

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Section: Results and Discusssionsupporting

confidence: 90%

Section: Results and Discusssionmentioning

confidence: 99%

Preparation of biocompatible magnetic microspheres with chitosan

Nasra¹,

Mohamed²,

Elblbesy³

et al. 2011

JBNB

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“…Preparation of magnetic microspheres [14]1% weight/ weight (W/W) chitosan (SHIN ERA TECHNOLOGY CO., LTD, China) was dissolved in acetate buffer at pH 4.5 containing 2 mL of magnetic fluid [15] (35% weight/ volume (W/V)) ferrous sulfate solution mixed with 54% W/V ferric chloride solution, stirred and heated to 550C, then 36% W/V sodium hydroxide solution was added. The mixture was stirred for 30 minutes, and then 5 g of polyethylene glycol-10000 was added,Statistical analysis: The data analysis was performed using the SPSS-10 package (release 3, SPSS Inc., Chicago III) running on MCROVAX 3500.…”

Section: Methodsmentioning

confidence: 99%

Study of the Effect of Magnetic Microspheres on Some Biophysical Parameters of Human Blood (In vitro Study)

Hereba¹

2012

J Biotechnol Biomaterial

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Magnetic microspheres have many bio-medical applications, but they have contact with the blood before reaching to their target place in many cases, so the study of the effect of these microspheres on the blood can lead to optimization of the use of these microspheres. Five groups of normal blood samples were incubated with 10 mg magnetic chitosan microspheres for 1, 3, 6, 12, and 24 hours (h) respectively, then each group was compared to control group samples. The results showed that increase in hemoglobin conductivity with the time of incubation, no change in red blood cells osmotic fragility, no change in hemoglobin absorbance spectrum. Decrease in blood pH at 24 h, no change in neither hemoglobin electrophoretic patterns or in the blood components ultra structures. These results indicated no obvious toxicity of the magnetic microspheres on blood for incubation time up to 24 h, but on the other hand there are some changes especially at 24 h of incubation, so it is safer to avoid the remaining of the microspheres inside the body for more than 24 h.

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“…Aliquots were taken at different time intervals and percentage drug release analysed by UV Spectrophotometer at 230 nm (Zhang et al, 2007). Figure 14 represents the comparison of dissolution studies conducted on formulations F1, F2 and F3.…”

Section: Dissolution Studiesmentioning

confidence: 99%

Preparation of magnetic microspheres of mesalamine by phase separation emulsion polymerisation technique

Kakar¹,

Singh²

2014

Afr. J. Pharm. Pharmacol.

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The study involved magnetic microspheres of mesalamine prepared by phase separation emulsion polymerization (PSEP) method technique. Magnetic microspheres were prepared by PSEP method to target them to the colon. Three polymers namely Eudragit S 100, ethylcellulose and chitosan were used for the preparation of magnetic microspheres. Magnetite content and entrapment of mesalamine was evaluated. Eudragit S 100, ethylcellulose and chitosan were used as polymers. Fourier transform infrared spectroscopy (FTIR) spectrum of drug and polymer was taken to visualize the compatibility of drug and polymer. Scanning electron microscope (SEM) images show the uniformity and particle size of the microspheres formed. The in vitro release study was carried out in phosphate buffer pH 6.8. The various results obtained were fit into the mathematical models and the Higuchi model was found to be most suitable for the formulations. Chitosan magnetic microspheres prepared by phase separation emulsion polymerization were found to be best in all the evaluation parameters (practical yield, magnetite content, magnetic responsivity of microspheres, particle size, in vitro release studies). They contain maximum magnetite content which is the utmost feature for the magnetic microspheres. Microspheres can be targeted by the external magnetic field applied due to magnetite entrapped. Thus toxicity and reticuloendothelial clearance can be minimized.

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Composite magnetic microspheres: Preparation and characterization

Cited by 27 publications

References 15 publications

Preparation of biocompatible magnetic microspheres with chitosan

Preparation of biocompatible magnetic microspheres with chitosan

Study of the Effect of Magnetic Microspheres on Some Biophysical Parameters of Human Blood (In vitro Study)

Preparation of magnetic microspheres of mesalamine by phase separation emulsion polymerisation technique

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