Composite lymphoma comprising mantle cell lymphoma and Epstein-Barr virus positive classic Hodgkin lymphoma: A rare case

Sharma, Shivani; Singh, Vishal; Bisaria, Dipti; Tangri, Rajiv

doi:10.4103/ijpm.ijpm_34_18

Cited by 6 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[5] Looking at the age distribution, composite lymphomas are generally seen in elderly patients and the age of patients is between 61 and 89 years. [1,[3][4][5] Our 53-year-old patient is the youngest patient among biclonal composite MCL and HL cases.…”

Section: Discussionmentioning

confidence: 80%

“…[4] In the literature, 10 cases with composite MCL and HL are encountered. [1,3,8] However, it is reported that only 4 of these cases developed from two distinct clones. [1,4,5] In our case, with the use of immunohistochemistry and FISH analysis, cyclin D1 positivity and gene rearrangement were detected in mantle cells, but no mutations in HRS cells.…”

Section: Discussionmentioning

confidence: 99%

“…[1,2] In the literature, composite lymphomas developed from different clones are rare and presented as case reports. [1,[3][4][5][6] Hodgkin lymphoma (HL) is often reported to form a composite with B cell lymphomas such as follicular lymphoma, chronic lymphocytic leukemia, and diffuse large B cell lymphoma. [5,6] Here, we present a lymphocyte-rich HL, which coexists with classical mantle cell lymphoma in the same lymph node.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Composite Mantle Cell Lymphoma and EBV Positive Classical Hodgkin Lymphoma: Case Report

barışık¹

2022

South Clin Ist Euras

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Composite Mantle Cell Lymphoma and EBV Positive Classical Hodgkin Lymphoma: Case Report

barışık¹

2022

South Clin Ist Euras

View full text Add to dashboard Cite

“…A total of 11 cHL/mantle cell composite lymphomas from 10 articles were analyzed [ 6 , 8 , 9 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ].…”

Section: Resultsmentioning

confidence: 99%

Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review

Trécourt

Donzel

Fontaine

et al. 2022

Cancers

View full text Add to dashboard Cite

The co-occurrence of several lymphomas in a patient defines composite/synchronous lymphoma. A common cellular origin has been reported for both contingents of such entities. In the present review, we aimed to gather the available data on composite lymphomas associating a classical Hodgkin lymphoma (cHL) with another lymphoma, to better understand the plasticity of mature B and T-cells. This review highlights that >70% of patients with a composite lymphoma are ≥55 years old, with a male predominance. The most reported associations are cHL with follicular lymphoma or diffuse large B-cell lymphoma, with over 130 cases reported. The cHL contingent is often of mixed cellularity type, with a more frequent focal/weak CD20 expression (30% to 55.6%) compared to de novo cHL, suggesting a particular pathophysiology. Moreover, Hodgkin cells may express specific markers of the associated lymphoma (e.g., BCL2/BCL6 for follicular lymphoma and Cyclin D1 for mantle cell lymphoma), sometimes combined with common BCL2/BCL6 or CCND1 rearrangements, respectively. In addition, both contingents may share similar IgH/IgK rearrangements and identical pathogenic variants, reinforcing the hypothesis of a common clonal origin. Finally, cHL appears to be endowed with a greater plasticity than previously thought, supporting a common clonal origin and a transdifferentiation process during lymphomagenesis of composite lymphomas.

show abstract

“…CL is rarely described in literature, and its description has been limited to isolated case reports (9)(10)(11)(12). However, its incidence may be underestimated as sophisticated techniques are required in the diagnosis of CL, and, due to its inconsistent definitions, the incidence of CL reported across different studies varies (13).…”

Section: Literature Reviewmentioning

confidence: 99%

Composite lymphoma of cervical lymph nodes with classical Hodgkin lymphoma and diffuse large B cell lymphoma: a case report and literature review

Wang

Zhang

2020

Ann Palliat Med

View full text Add to dashboard Cite

Composite lymphoma (CL) is a clinically rare entity, with unknown pathogenic mechanisms. Its diagnosis is quite difficult, and there is currently no proven treatment. In this article, we report a 64-year-old male patient presenting with swelling and mild pain in the bilateral cervical lymph nodes. Radiology revealed lesions only involved the neck. Histological examination showed that the tumor tissue had two components: mixed cellularity classical Hodgkin lymphoma (CHL-MC) and diffuse large B cell lymphoma (DLBCL).The final diagnosis was CL in the bilateral cervical lymph nodes composed of CHL-MC and DLBCL stage IA. The patient received six cycles of rituximab plus cyclophosphamide, pirubicin, vincristine, and prednisone (R-CHOP) and two cycles of rituximab maintenance therapy, and complete response (CR) was achieved. No progression was found during the 9 months of follow-up. We conducted a literature review of 28 cases of CL with CHL and DLBCL. The demography of the disease, the location of the disease involved, the subtype of CHL, the Epstein-Barr virus infection, treatment and survival were described in detail. In the discussion section, we analyzed the definition, pathogenesis, diagnosis, treatment and prognosis of CL. We hope that through case reports and literature review, we can improve the understanding of CL and optimize its treatment.

show abstract

Composite lymphoma comprising mantle cell lymphoma and Epstein-Barr virus positive classic Hodgkin lymphoma: A rare case

Cited by 6 publications

References 0 publications

Composite Mantle Cell Lymphoma and EBV Positive Classical Hodgkin Lymphoma: Case Report

Composite Mantle Cell Lymphoma and EBV Positive Classical Hodgkin Lymphoma: Case Report

Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review

Composite lymphoma of cervical lymph nodes with classical Hodgkin lymphoma and diffuse large B cell lymphoma: a case report and literature review

Contact Info

Product

Resources

About