Composite iron oxide&amp;ndash;Prussian blue nanoparticles for magnetically guided T&lt;sub&gt;1&lt;/sub&gt;-weighted magnetic resonance imaging and photothermal therapy of tumors

Kale, Shraddha; Burga, Rachel A.; Sweeney, Elizabeth E.; Zun, Zungho; Sze, Raymond W.; Tuesca, Anthony; Subramony, J. Anand; Fernandes, Rohan

doi:10.2147/ijn.s144515

Cited by 29 publications

(24 citation statements)

References 39 publications

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“…IONs can be combined with other inorganic nanoparticles such as molybdenum sulfide [ 72 , 73 ], manganese [ 74 ], copper/selenium [ 75 , 76 ], graphene oxides [ 77 , 78 ], manganese and graphene oxide [ 79 ], Prussian blue [ 80 , 81 ], and copper sulfide [ 82 ].…”

Section: Iron Oxide Nanoparticles For Photothermal Therapymentioning

confidence: 99%

Iron Oxide Nanoparticles in Photothermal Therapy

2018

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Photothermal therapy is a kind of therapy based on increasing the temperature of tumoral cells above 42 °C. To this aim, cells must be illuminated with a laser, and the energy of the radiation is transformed in heat. Usually, the employed radiation belongs to the near-infrared radiation range. At this range, the absorption and scattering of the radiation by the body is minimal. Thus, tissues are almost transparent. To improve the efficacy and selectivity of the energy-to-heat transduction, a light-absorbing material, the photothermal agent, must be introduced into the tumor. At present, a vast array of compounds are available as photothermal agents. Among the substances used as photothermal agents, gold-based compounds are one of the most employed. However, the undefined toxicity of this metal hinders their clinical investigations in the long run. Magnetic nanoparticles are a good alternative for use as a photothermal agent in the treatment of tumors. Such nanoparticles, especially those formed by iron oxides, can be used in combination with other substances or used themselves as photothermal agents. The combination of magnetic nanoparticles with other photothermal agents adds more capabilities to the therapeutic system: the nanoparticles can be directed magnetically to the site of interest (the tumor) and their distribution in tumors and other organs can be imaged. When used alone, magnetic nanoparticles present, in theory, an important limitation: their molar absorption coefficient in the near infrared region is low. The controlled clustering of the nanoparticles can solve this drawback. In such conditions, the absorption of the indicated radiation is higher and the conversion of energy in heat is more efficient than in individual nanoparticles. On the other hand, it can be designed as a therapeutic system, in which the heat generated by magnetic nanoparticles after irradiation with infrared light can release a drug attached to the nanoparticles in a controlled manner. This form of targeted drug delivery seems to be a promising tool of chemo-phototherapy. Finally, the heating efficiency of iron oxide nanoparticles can be increased if the infrared radiation is combined with an alternating magnetic field.

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Section: Iron Oxide Nanoparticles For Photothermal Therapymentioning

confidence: 99%

Iron Oxide Nanoparticles in Photothermal Therapy

2018

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“…The development of new MRI contrast agents based on NPs is a fascinating field of research that focuses on improving MRI techniques for the early detection of disease. Superparamagnetic NPs such as ferric oxide (Fe 3 O 4 ) have been extensively employed as an MRI contrast agent [ 4 – 10 ], altering the magnetic resonance (MR) signals by reducing the relaxivity through de-phasing of the transverse magnetization [ 11 , 12 ]. A gold (Au) shell coating may be useful in this regard in order to enhance not only the imaging contrasts for MRI but also the photothermal effect via the plasmon-derived optical resonances of gold shells in the visible and near-infrared region (NIR) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Polymer coated gold-ferric oxide superparamagnetic nanoparticles for theranostic applications

et al. 2018

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BackgroundEngineered inorganic nanoparticles (NPs) are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids. In many cases however, functionalization is not sufficient: the particles become either coated by a corona of serum proteins or precipitate out of the solvent. We show that by changing the coating of magnetic iron oxide NPs using poly-l-lysine (PLL) polymer the colloidal stability of the dispersion is improved in aqueous solutions including water, phosphate buffered saline (PBS), PBS with 10% fetal bovine serum (FBS) and cell culture medium, and the internalization of the NPs toward living mammalian cells is profoundly affected.MethodsA multifunctional magnetic NP is designed to perform a near-infrared (NIR)-responsive remote control photothermal ablation for the treatment of breast cancer. In contrast to the previously reported studies of gold (Au) magnetic (Fe3O4) core–shell NPs, a Janus-like nanostructure is synthesized with Fe3O4 NPs decorated with Au resulting in an approximate size of 60 nm mean diameter. The surface of trisoctahedral Au–Fe3O4 NPs was coated with a positively charged polymer, PLL to deliver the NPs inside cells. The PLL–Au–Fe3O4 NPs were characterized by transmission electron microscopy (TEM), XRD, FT-IR and dynamic light scattering (DLS). The unique properties of both Au surface plasmon resonance and superparamagnetic moment result in a multimodal platform for use as a nanothermal ablator and also as a magnetic resonance imaging (MRI) contrast agent, respectively. Taking advantage of the photothermal therapy, PLL–Au–Fe3O4 NPs were incubated with BT-474 and MDA-MB-231 breast cancer cells, investigated for the cytotoxicity and intracellular uptake, and remotely triggered by a NIR laser of ~ 808 nm (1 W/cm2 for 10 min).ResultsThe PLL coating increased the colloidal stability and robustness of Au–Fe3O4 NPs (PLL–Au–Fe3O4) in biological media including cell culture medium, PBS and PBS with 10% fetal bovine serum. It is revealed that no significant (< 10%) cytotoxicity was induced by PLL–Au–Fe3O4 NPs itself in BT-474 and MDA-MB-231 cells at concentrations up to 100 μg/ml. Brightfield microscopy, fluorescence microscopy and TEM showed significant uptake of PLL–Au–Fe3O4 NPs by BT-474 and MDA-MB-231 cells. The cells exhibited 40 and 60% inhibition in BT-474 and MDA-MB-231 cell growth, respectively following the internalized NPs were triggered by a photothermal laser using 100 μg/ml PLL–Au–Fe3O4 NPs. The control cells treated with NPs but without laser showed < 10% cell death compared to no laser treatment controlConclusionCombined together, the results demonstrate a new polymer gold superparamagnetic nanostructure that integrates both diagnostics function and photothermal ablation of tumors into a single multimodal nanoplatform exhibiting a significant cancer cell death.Electronic supplementary materialThe online version of this article (10.1186/s12951-018-0405-7)...

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“…Nanoparticle‐based photothermal therapy (PTT) has been widely investigated in cancer therapy as a rapid and minimally invasive tumor ablation technique . In this treatment modality, the intrinsic photothermal conversion property of synthesized nanoparticles is used for tumor control . This property allows the conversion of incident light into heat, which generates cell temperature increases, thereby killing cancer cells in contact with the nanoparticles.…”

mentioning

confidence: 99%

“…This property allows the conversion of incident light into heat, which generates cell temperature increases, thereby killing cancer cells in contact with the nanoparticles. Over the past two decades, several reports utilizing nanoparticles for PTT of diverse tumor types in vitro and in vivo have been described …”

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confidence: 99%

Photothermal Therapy Generates a Thermal Window of Immunogenic Cell Death in Neuroblastoma

Sweeney

Cano‐Mejia

Fernandes

2018

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A thermal "window" of immunogenic cell death (ICD) elicited by nanoparticle-based photothermal therapy (PTT) in an animal model of neuroblastoma is described. In studies using Prussian blue nanoparticles to administer photothermal therapy (PBNP-PTT) to established localized tumors in the neuroblastoma model, it is observed that PBNP-PTT conforms to the "more is better" paradigm, wherein higher doses of PBNP-PTT generates higher cell/local heating and thereby more cell death, and consequently improved animal survival. However, in vitro analysis of the biochemical correlates of ICD (ATP, high-motility group box 1, and calreticulin) elicited by PBNP-PTT demonstrates that PBNP-PTT triggers a thermal window of ICD. ICD markers are highly expressed within an optimal temperature (thermal dose) window of PBNP-PTT (63.3-66.4 °C) as compared with higher (83.0-83.5 °C) and lower PBNP-PTT (50.7-52.7 °C) temperatures, which both yield lower expression. Subsequent vaccination studies in the neuroblastoma model confirm the in vitro findings, wherein PBNP-PTT administered within the optimal temperature window results in long-term survival (33.3% at 100 d) compared with PBNP-PTT administered within the higher (0%) and lower (20%) temperature ranges, and controls (0%). The findings demonstrate a tunable immune response to heat generated by PBNP-PTT, which should be critically engaged in the administration of PTT for maximizing its therapeutic benefits.

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Composite iron oxide–Prussian blue nanoparticles for magnetically guided T<sub>1</sub>-weighted magnetic resonance imaging and photothermal therapy of tumors

Cited by 29 publications

References 39 publications

Iron Oxide Nanoparticles in Photothermal Therapy

Iron Oxide Nanoparticles in Photothermal Therapy

Polymer coated gold-ferric oxide superparamagnetic nanoparticles for theranostic applications

Photothermal Therapy Generates a Thermal Window of Immunogenic Cell Death in Neuroblastoma

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