Composite Inflammatory Indicators as Early Predictor of Intra-abdominal Infections after General Surgery

Song, Jun; Lu, Yurong

doi:10.2147/jir.s340745

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Since it increases in correlation with the severity and duration of the infection, this marker is a valuable marker for predicting the prognosis and outcome of patients with sepsis. 38 In a recent study, Song et al 38 found that serum expression of TNF-α and IL-6 were associated with IAIs in patients after surgery. A composite of IL-6, PCT, and TNF-α can also increase the reliability of the prediction of postoperative infections.…”

Section: Interleukin-6mentioning

confidence: 99%

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

Peksöz¹,

Agirman²,

Şentürk³

et al. 2023

Eurasian J Med

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Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection according to the Third International Consensus Definitions for Sepsis and Septic Shock definitions. It is a clinical condition with high morbidity and mortality due to its complex pathophysiology and lack of a complete treatment. It constitutes a significant economic burden because it constitutes a substantial part of intensive care patients, and the treatment process is lengthy and costly. Therefore, early diagnosis and treatment of the disease are essential. After pneumonia, an essential source of sepsis is intra-abdominal infection. Due to the presence of multiple and polymicrobial sources of infection, abdominal sepsis progresses more seriously. The effective treatment of intra-abdominal infection consists of early recognition of the disease, control of the source, appropriate antibiotic therapy, and stabilization in the intensive care setting with an excellent surgical approach. We searched PubMed, EMBASE, MEDLINE, and the Cochrane Library. Two authors reviewed all identified abstracts and selected articles for full-text review. We included original studies assessing mediators in intra-abdominal sepsis. Inflammatory and protein mediators such as acute phase protein and chemokine cytokines play an essential role in intra-abdominal sepsis. In clinical practice, white blood cell count, C-reactive protein, and procalcitonin are the most used parameters in the definition of abdominal infection. Tumor necrosis factor-alpha, interleukin-6, high-mobility group protein B1, and presepsin are other markers with high diagnostic efficiency, even though they are not used routinely. Despite everything, there is a need for highly effective markers that can be used in the diagnosis and follow-up of sepsis. Great hope is attached to these markers. This review aims to discuss the importance of the most used markers in the diagnosis and follow-up of abdominal sepsis and the markers on which there are essential studies in light of current literature.

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Section: Interleukin-6mentioning

confidence: 99%

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

Peksöz¹,

Agirman²,

Şentürk³

et al. 2023

Eurasian J Med

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Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection

Huang,

Yang,

Yang

et al. 2024

BMC Surg

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Background To investigate the role of C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) as early predictors of infectious complications after laparoscopic gastric cancer surgery. Methods Patients who underwent laparoscopic gastric cancer surgery between January 2020 and June 2022 were retrospectively enrolled. IL-6, PCT, and CRP levels were assessed before surgery and on postoperative days (PODs) 3 and 5. Differences in serum IL-6, PCT, and CRP levels between the infected and non-infected groups were compared. The diagnostic accuracy was determined using the area under the receiver operating characteristic curve (AUC). Results A total of 206 patients were enrolled, and 21 patients (10.19%) developed postoperative infections. Serum IL-6, PCT, and CRP levels in the infected group were significantly higher than those in the non-infected group on PODs 3 and 5. IL-6 with an optimal cutoff value of 84.00 pg/mL (AUC 0.84), PCT with an optimal cutoff value of 1.39 ng/mL (AUC 0.80), CRP with an optimal cutoff value of 150.00 mg/L (AUC 0.76) on POD 3 had superior diagnostic accuracy in predicting postoperative infections. Multivariate analysis identified PCT and IL-6 levels on POD 3 as independent risk factors, the AUC of the combination of IL-6 and PCT was 0.89. The Delong test showed no difference between the AUC of IL-6 alone and IL-6 combined with PCT prediction (P = 0.07, Z = 1.81). Conclusions IL-6 level on POD 3 is an excellent predictor of infectious complications following laparoscopic gastric cancer surgery. Patients with IL-6 levels lower than 84.00 pg/mL on POD 3 can ensure safe early discharge with a low probability of infection.

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Composite Inflammatory Indicators as Early Predictor of Intra-abdominal Infections after General Surgery

Cited by 2 publications

References 37 publications

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection

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