Composite Hodgkin lymphoma and chronic lymphocytic leukemia: A rare case

Rathnam, Krishnakumar; Karpurmath, Shashidhar V.; Cyriac, Sanju; Gnana, Sagar Tenali; Sundersingh, Shirley

doi:10.4103/0973-1482.92006

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Among the remaining 99 articles, 26 were excluded from the final analysis because they met at least one exclusion criterion: (i) six NLPHL/NHL composite lymphomas without cHL contingent [ 27 , 28 , 29 , 30 , 31 , 32 ]; (ii) two cHL with an Epstein–Barr virus (EBV) post-transplant lymphoproliferative disorder [ 33 ] or EBV mucocutaneous ulcer [ 34 ]; (iii) one with CD30 negative Hodgkin cells [ 35 ]; (iv) four with Hodgkin-like cells within an NHL [ 36 , 37 , 38 , 39 ]; (v) two sequential lymphomas [ 40 , 41 ]; (vi) ten probable transformations of CCL into cHL [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]; and (vii) one because the final diagnosis could be considered ambiguous [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review

Trécourt

Donzel

Fontaine

et al. 2022

Cancers

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The co-occurrence of several lymphomas in a patient defines composite/synchronous lymphoma. A common cellular origin has been reported for both contingents of such entities. In the present review, we aimed to gather the available data on composite lymphomas associating a classical Hodgkin lymphoma (cHL) with another lymphoma, to better understand the plasticity of mature B and T-cells. This review highlights that >70% of patients with a composite lymphoma are ≥55 years old, with a male predominance. The most reported associations are cHL with follicular lymphoma or diffuse large B-cell lymphoma, with over 130 cases reported. The cHL contingent is often of mixed cellularity type, with a more frequent focal/weak CD20 expression (30% to 55.6%) compared to de novo cHL, suggesting a particular pathophysiology. Moreover, Hodgkin cells may express specific markers of the associated lymphoma (e.g., BCL2/BCL6 for follicular lymphoma and Cyclin D1 for mantle cell lymphoma), sometimes combined with common BCL2/BCL6 or CCND1 rearrangements, respectively. In addition, both contingents may share similar IgH/IgK rearrangements and identical pathogenic variants, reinforcing the hypothesis of a common clonal origin. Finally, cHL appears to be endowed with a greater plasticity than previously thought, supporting a common clonal origin and a transdifferentiation process during lymphomagenesis of composite lymphomas.

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Section: Resultsmentioning

confidence: 99%

Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review

Trécourt

Donzel

Fontaine

et al. 2022

Cancers

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show abstract

“…Composite classical Hodgkin lymphoma (CHL) and non-Hodgkin lymphoma (NHL) are uncommon. The reported NHLs in composite lymphoma are most commonly B cell lymphoma, including diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma (MZL), and chronic lymphocytic leukemia/small lymphocytic lymphoma [3][4][5][6][7][8]. Composite lymphoma with CHL and MZL is rare and has never been reported in pediatric population [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%