Composite endpoints in COVID-19 randomized controlled trials: a systematic review
Pedro Nascimento Martins,
Mateus Henrique Toledo Lourenço,
Gabriel Paz Souza Mota
et al.
Abstract:Background/Aims This study aimed to determine the prevalence of ordinal, binary, and numerical composite endpoints among coronavirus disease 2019 trials and the potential bias attributable to their use. Methods We systematically reviewed the Cochrane COVID-19 Study Register to assess the prevalence, characteristics, and bias associated with using composite endpoints in coronavirus disease 2019 randomized clinical trials. We compared the effect measure (relative risk) of composite outcomes and that of its most … Show more
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