Composite cerebrospinal fluid score in relapsing-remitting and secondary progressive multiple sclerosis

Jongen, P.J.H.; Floris, S.; Doesburg, W.H.; Lemmens, W.A.J.G.; Hommes, O.R.; Lamers, K.J.B.

doi:10.1191/135245898678909330

Cited by 5 publications

(6 citation statements)

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“…Our results do not support this hypothesis. No elevations of CSF NSE levels were recorded, a finding that is in line with some previous reports 32,38. Motor and cognitive function and T2-weighted MRI hyperintensitiesR.…”

supporting

confidence: 89%

Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS

Malmeström¹,

Haghighi²,

Rosengren³

et al. 2003

Neurology

283

250

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supporting

confidence: 89%

Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS

Malmeström¹,

Haghighi²,

Rosengren³

et al. 2003

Neurology

283

250

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“…All examinations were performed before randomization for study treatment. Results from an elaborate CSF analysis in these patients, comparing the relapsing-remitting with the secondary progressive group, have been published previously [9, 10]. …”

Section: Methodsmentioning

confidence: 99%

Cerebrospinal Fluid IgM Index Correlates with Cranial MRI Lesion Load in Patients with Multiple Sclerosis

Jongen

Nijeholt²,

Lamers³

et al. 2007

Eur Neurol

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In multiple sclerosis intrathecal IgM synthesis correlates with an unfavourable disease course. Whether this reflects a pathogenic role of IgM, possibly in conjunction with complement, is a matter of debate. In a cross-sectional study we measured intrathecal synthesis of IgM and the complement component C3, and on cranial MRI lesion load and central brain atrophy in clinically active patients, 17 relapsing-remitting, 16 secondary progressive. Correlative analysis showed that in relapsing-remitting patients CSF IgM index correlated with cranial MRI T₂ and T₁ lesion load, and central brain atrophy; and the C3 index correlated with T₂ lesion load. In secondary progressive patients CSF IgM index correlated with periventricular T₂ lesion load. Our data are in favour of a pathogenic role of IgM in multiple sclerosis.

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“…24 In relapsing-remitting and secondary progressive multiple sclerosis (MS), CSF S100B increase associates the disease aggravation. 28…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Markers Combined With Metalloproteinase-9, Neopterin, and S100B Concentrations May Indicate the Pathogenesis of Central Nervous System Diseases in Children

et al. 2022

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The identification of central nervous system inflammation etiology leads to adjusted therapy. We analyzed the potential inflammatory and neuro-axonal damage markers in children. Our target was to correlate the findings with a disease's course or a sequalae risk and assess their clinical usefulness. The study included 96 children with symptoms of central nervous system inflammation who underwent diagnostics. The research group involved 24 children with autoimmune disorders and 31 with neuroinfection. The control group included patients with both etiologies excluded. We analyzed the results of routine laboratory tests together with chosen serum (neopterin, interleukin [IL]-1β, IL-6) and CSF (metalloproteinase [MMP]-9, S100B protein) markers. In the whole cohort, CSF MMP-9 correlated with CSF cytosis and serum IL-6 and CRP. In the undivided neuroinflammatory group, CSF S100B correlated with serum IL-6 and IgM concentrations. CSF cytosis was associated with CSF MMP-9 and serum neopterin levels. Among the infective patients, IL-6 was linked with increased CSF MMP-9. We conclude that astroglial protein S100B, neopterin, and cytokine concentrations may enable predicting long-term consequences, whereas CSF MMP-9 concentration may reflect the actual central nervous system injury regardless of etiology.

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Composite cerebrospinal fluid score in relapsing-remitting and secondary progressive multiple sclerosis

Cited by 5 publications

References 0 publications

Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS

Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS

Cerebrospinal Fluid IgM Index Correlates with Cranial MRI Lesion Load in Patients with Multiple Sclerosis

Inflammatory Markers Combined With Metalloproteinase-9, Neopterin, and S100B Concentrations May Indicate the Pathogenesis of Central Nervous System Diseases in Children

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